Publications by authors named "Guo-Fang Hu"
Article Synopsis
- Osteoarthritis (OA) is a prevalent condition in older adults, but the molecular mechanisms behind its development and progression are still unclear; this study explored these mechanisms using a competing endogenous RNA (ceRNA) network approach.
- Researchers analyzed various mRNA, miRNA, and lncRNA datasets to identify differentially expressed genes (DEGs) and constructed a ceRNA network to explore their biological functions through enrichment analyses, as well as assessing immune cell presence in OA versus healthy samples.
- Key findings revealed significant players like hsa-mir-425-3p and dual specificity phosphatase 1 in the ceRNA network, highlighting their roles in important biological processes linked to immune responses and OA progression, suggesting potential targets for further
Background: Indoleamine 2,3-dioxygenase (IDO) catalyzes the rate-limiting step of tryptophan (Trp) degradation via the kynurenine (Kyn) pathway, which inhibits the proliferation of T cells and induces the apoptosis of T cells, leading to immune tolerance. Therefore, IDO has been considered as the most important mechanism for tumor cells to escape from immune response. Previous studies suggested that IDO might be involved in the progression of tumor and resistance to chemotherapy.
View Article and Find Full Text PDFBackground: Pancreatic cancer is considered as a chemoresistant neoplasm with extremely dismal prognosis. Gemcitabine is recommended as the standard agent for locally advanced or metastatic pancreatic cancer. A series of trials have been conducted to improve the outcome of advanced pancreatic cancer with other anticancer drugs in combination with gemcitabine.
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