GRP75-mediated upregulation of HMGA1 stimulates stage I lung adenocarcinoma progression by activating JNK/c-JUN signaling.

Background: Recurrence is a major challenge in early-stage lung adenocarcinoma (LUAD) treatment. Here, we investigated the role and mechanism of high-mobility group AT-hook 1 (HMGA1) and glucose-regulated protein 75-kDa (GRP75) in stage I LUAD and evaluated their potential as biomarkers for predicting the recurrence and prognosis of stage I LUAD.

Methods: The TCGA dataset was used to investigate the clinical significance of HMGA1 and GRP75 in early-stage LUAD.

[Scaling relationships between twig size and leaf size of Pinus hwangshanensis along an altitudinal gradient in Wuyi Mountains, China.].

To analyze the tradeoff relationship between twigs and leaves, the traits of Pinus hwang-shanensis including leaf area, leaf number, twig length and twig diameter were investigated in Wuyi Mountains along an altitudinal gradient. The results indicated that leaf number, twig length, twig diameter, leafing intensity and twig stem cross-sectional area of P. hwangshanensis increased gra-dually with the increasing altitude, while individual leaf area decreased gradually.