Photochromic Metal-organic Frameworks Based on Host-guest Strategy and Different Viologen Derivatives for Organic Amines Sensing and Information Anticounterfeiting.

The encapsulation of viologen derivatives in metal-organic frameworks (MOFs) to construct host-guest materials has been widely discussed owing to their distinctive spatial arrangement and physical/chemical properties. Herein, three new photochromic MOFs (NWM-1-3) have been successfully synthesized by 1,1,2,2-Tetra(4-carboxylphenyl)ethylene (H4TCPE) ligand as well as three different viologen derivatives based on host-guest strategy. Remarkably, NWM-1-3 exhibit a notable reversible photochromism change from yellow to green under 365 nm UV irradiation.

The pharmacokinetics, pharmacodynamics and tolerability of SHR6508 in chinese healthy subjects: a randomized, placebo-controlled, double-blind, single-dose and dose-escalation phase I trial.

This study aimed to evaluate the pharmacokinetics (PK), pharmacodynamics (PD), safety, and tolerability of SHR6508 injection, a new calcimimetic agent, in healthy Chinese subjects following single dose. This study utilized a placebo-controlled, single-dose, and dose-escalation design with four dose groups (0.5 mg, 2.

A Scalable Pore-space-partitioned Metal-organic Framework Powered by Polycatenation Strategy for Efficient Acetylene Purification.

Efficient separation of acetylene (CH) from carbon dioxide (CO) and ethylene (CH) is a significant challenge in the petrochemical industry due to their similar physicochemical properties. Pore space partition (PSP) has shown promise in enhancing gas adsorption capacity and selectivity by reducing pore size and increasing the density of guest binding sites. Herein, we firstly employ the 2D→3D polycatenation strategy to construct a PSP metal-organic framework (MOF) Ni-dcpp-bpy, incorporating functional N/O sites to enhance CH purification.

Three in one: engineering MOF channels coordinated water arrays for regulated separation of alkanes and alkenes.

Purifying alkenes (mainly ethylene and propylene) by removing their corresponding alkanes is crucial yet challenging in the chemical industry. Selective physisorption shows promise for effective separation but demands precise pore dimensions and/or pore chemistry of adsorbents. We report an yttrium-based metal-organic framework, Y(TCHB)(OH)·2HO (HIAM-317, TCHB = 3,3',5,5'-tetrakis(4-carboxyphenyl)-2,2',4,4',6,6'-hexamethyl-1,1'-biphenyl), that can separate ethylene/ethane and propylene/propane mechanisms regulated by coordinated water arrays.

The Assembly of Cerium(III)-Containing Silicotungstate with Lewis Acid-Base Sites Enables the Selective -Alkenylation of Oxindole.

A cerium(III)-containing silicotungstate, [HN(CH)]NaK[KCe(SiWO)(HO)]·18.5HO (), was successfully synthesized and characterized. Structure analysis reveals that is composed of two {SiWO} units connected by one cerium(III) cation to form a typical 1:2 sandwich structure, which is further expanding into a 1D chain linked by K ions.

An Unusual Crystalline Porous Framework Constructed from Multitypes of Cages with Proton Conduction Property and Heterogeneous Catalytic Activity for Pyrazole Synthesis.

An unusual crystalline porous framework constructed from four types of cages, including all-inorganic Keggin-type polyoxometalate (POM) cages [HWO], organic hexamethylenetetramine (Hmt) cages, nanosized silver-Hmt coordination cages, and giant POM-silver-Hmt cages, was hydrothermally synthesized and structurally characterized. The framework features a highly symmetrical structure with one-dimensional nanoscale channels and holds good thermal/solvent stability, which endow it with proton conduction properties and heterogeneous catalytic activity for pyrazole. This paper not only contributes to broadening the structural diversity of cage-based crystalline porous framework materials but also sheds new light on the design of new functional framework materials.

Pure separation of acetylene based on a sulfonic acid and amino group functionalized Zn-MOF.

The dual-ligand strategy was employed to synthesize a new microporous material, [Zn(SNDC)(AmTAZ)(HO)]·HO·CHCN (), incorporating sulfonic acid and amino groups for enhancing gas adsorption and separation. The activated (named ) exhibited selective adsorption of acetylene over carbon dioxide and methane. Hence, the dual-ligand strategy optimized the pore environment and provided an effective approach for pure separation of gases.

Diagnosis and treatment of post-cholecystectomy diarrhoea.

The incidence of cholecystitis is relatively high in developed countries and may usually be attributed to gallstones, the treatment for which involves complete surgical removal of the gallbladder (cholecystectomy). Bile acids produced following cholecystectomy continue to flow into the duodenum but are poorly absorbed by the colon. Excessive bile acids in the colon stimulate mucosal secretion of water and electrolytes leading, in severe cases, to diarrhoea.

Complete mitochondrial genome of and in China provides insights into fleas phylogeny.

Fleas (Order Siphonaptera) are common blood-feeding ectoparasites, which have important economic significance. Limited mitochondrial genome information has impeded the study of flea biology, population genetics and phylogenetics. The and complete mt genomes are described in this study.

Separation of CH/CH/CH and CH/CO in a Nitrogen-Rich Copper-Based Microporous Metal-Organic Framework.

The purification of industrially valuable CH and CH from multicomponent mixtures represents a crucial process in the chemical industry. In this study, we present a copper-based metal-organic framework () built on a nitrogen-rich organic linker that is capable of separating CH/CH/CH and CH/CO mixtures, therefore producing highly pure CH and CH, respectively. exhibits favorable adsorption of CH and CH over CH and thus achieves one-step CH purification from CH/CH/CH ternary mixtures, as verified by multicomponent breakthrough measurements.

DKADE: a novel framework based on deep learning and knowledge graph for identifying adverse drug events and related medications.

Adverse drug events (ADEs) are common in clinical practice and can cause significant harm to patients and increase resource use. Natural language processing (NLP) has been applied to automate ADE detection, but NLP systems become less adaptable when drug entities are missing or multiple medications are specified in clinical narratives. Additionally, no Chinese-language NLP system has been developed for ADE detection due to the complexity of Chinese semantics, despite ˃10 million cases of drug-related adverse events occurring annually in China.

Efficient CH-selective separation in a microporous Zn(II)-based metal-organic framework the dual-ligand strategy.

Implementing the dual-ligand strategy, a microporous Zn-based MOF 1 with nitro and amino groups was effectively produced. The activated interconnected pores of 1 exhibited high CH uptake capacity and preferential adsorption behaviour for CH over CO, as identified by the experiments and simulations. This work provides a new approach for designing and synthesizing the MOFs with desired structures and properties by optimizing their pore environment the dual-ligand strategy.

Ameliorating Adsorption Performance for Poisonous Methylene Blue through the Amino Functionalization of Metal-Organic Frameworks.

Amino (-NH)-functionalized metal-organic frameworks (MOFs) are widely applied to improve the properties of materials owing to the rich host-guest chemical properties of amino groups. In this work, the amino-functionalization strategy was thus employed to improve the sorption performance of methylene blue (MB). The introduction of -NH groups in did not reduce the pore size of the framework but rather modulated and optimized the host-guest interactions of MOFs.

Self-Assembly of a U(VI)-Containing Polytungstate Tetramer with Lewis Acid-Base Catalytic Activity for a Dehydration Condensation Reaction.

A novel U(VI)-containing polytungstate (U-POW) tetramer, {KNa[K(UO)Cl(OH)(γ-SiWO)]}·ca66HO (), was synthesized using the Keggin-type precursor [γ-SiWO] and UO(NO). was further characterized by single-crystal X-ray diffraction, FT-IR, Raman spectroscopy, solid-state diffuse reflection spectroscopy, ICP-OES, ESI-MS, TGA, and PXRD. The central {K(UO)Cl(OH)} chromophore was constructed dexterously from four uranyl, four halves of K ions, 5.

Safety, Pharmacokinetics/Pharmacodynamics, and Absolute Bioavailability of Dexmedetomidine Hydrochloride Nasal Spray in Healthy Subjects: A Randomized, Parallel, Escalating Dose Study.

The present study evaluated the safety, pharmacokinetics/pharmacodynamics (PK/PD), and absolute bioavailability (Fabs) of Dex nasal spray in healthy adult subjects, which serves as a bridge for the subsequent study in children. Part 1: a double-blind, placebo-controlled, single ascending dose study was performed on 48 subjects. For 20-/40-μg groups, every 6/2 subjects received either Dex/placebo nasal spray or Dex/placebo injection in two periods.

Highly Efficient I Sorption, CO Capture, and Catalytic Conversion by Introducing Nitrogen Donor Sites in a Microporous Co(II)-Based Metal-Organic Framework.

Recently, the development of porous absorbents for efficient CO and I capture has attracted considerable attention because of severe global climate change and environmental issues with the nuclear energy. Hence, a unique porous metal-organic framework (MOF), {[Co(L)]·DMF·2HO} (, DMF = ,-dimethylformamide) with uncoordinated N atoms was rationally constructed via using a heterofunctional 4,6-bis(4'-carboxyphenyl)pyrimidine (HL) linker. Interestingly, exhibits exceptional properties for I sorption, CO capture, and catalytic conversion.

The largest Se-4f cluster incorporated polyoxometalate with high Lewis acid-base catalytic activity.

A 4p-4f cluster incorporated polyoxometalate (POM), namely, H{[(Hpic)EuSeO(HO)](α-GeWO)·40HO (1-Eu, Hpic = isonicotinic acid), has been first synthesized and characterized. 1-Eu features an interesting four-shell structure, representing the largest Se-4f cluster incorporated POM known to date. Besides, 1-Eu exhibits excellent Lewis acid-base catalytic activity and reusablity in catalyzing the gram-scale dehydration condensation reaction of hydrazines and 1,3-diketones to synthesize polysubstituted pyrazoles.