Integrated analysis of multiple programmed cell death-related prognostic genes and functional validation of apoptosis-related genes in osteosarcoma.

Osteosarcoma (OS) is one of the most prevalent bone malignancies with a poor prognosis. Various types of programmed cell death patterns can influence cancer progression and response to treatment. We aimed to integrate different molecular characteristics of cell death for risk stratification and personalized therapy.

Decoupling of global signal and cerebrospinal fluid inflow is associated with cognitive decline in patients with obstructive sleep apnoea.

Objectives: The role of cortical glymphatic dysfunction in the cognitive impairment of the obstructive sleep apnea (OSA) requires further study. To compare the coupling between the resting-state blood-oxygen-level-dependent (BOLD) signals and cerebrospinal fluid (CSF) signals (BOLD-CSF coupling), a proxy for the cortical glymphatic function, across patients with differing severities of OSA and relate them with disease characteristics and treatment.

Methods: A total of 153 participants (89 OSA patients and 64 matched controls) were prospectively included.

Discovery and identification of semaphorin 4D as a bioindicator of high fracture incidence in type 2 diabetic mice with glucose control.

Introduction: Bone fracture is increasing in patients with type 2 diabetes mellitus (T2DM) due to skeletal fragility. Most antidiabetics are expected to reduce the incidence of fracture in patients with T2DM, however the results are disappointing. Metformin and GLP-1 receptor agonists have a neutral or minor positive effect in reducing fractures.

Gate-Tunable Dual-Mode Optoelectronic Device for Self-Powered Photodetector and Optoelectronic Synapse.

In the advancing field of optoelectronics, multifunctional devices that integrate both detection and processing capabilities are increasingly desirable. Here, a gate-tunable dual-mode optoelectronic device based on a MoTe/MoS van der Waals heterostructure, designed to operate as both a self-powered photodetector and an optoelectronic synapse, is reported. The device leverages the photovoltaic effect in the MoTe/MoS PN junction for self-powered photodetection and utilizes trapping states at the SiO/MoS interface to emulate synaptic behavior.

Long non-coding RNA-MIR181A1HG acts as an oncogene and contributes to invasion and metastasis in gastric cancer.

Dysregulation of long non-coding RNAs (lncRNA) plays an essential role in cancer development and progression. However, their functions and mechanisms of action in gastric cancer (GC) remain largely unknown. Gene expression in GC was evaluated using quantitative real-time PCR, western blotting, immunofluorescence, immunohistochemistry, and RNA in situ hybridization.

Sedentary Leisure Behaviour, Physical Activity, and Gastroesophageal Reflux Disease: Evidence From a Mendelian Randomization Analysis.

Background And Aims: Gastroesophageal reflux disease (GERD) is common worldwide. Although associations between sedentary behaviour (LSBs), physical activity (PAs), and GERD have been reported, their causal relationships remain unclear. This study uses Mendelian randomization (MR) to examine these associations with GERD.

transcription factor regulates anthocyanin biosynthesis in the epidermis of tender asparagus stems.

Introduction: Asparagus is a valuable vegetable, and its edible part is a tender stem. The color of the tender stem epidermis is an important trait. In particular, purple asparagus is rich in anthocyanins.

Immunoregulatory Neuro-Vascularized Osseointegration Driven by Different Nano-Morphological CaTiO Bioactive Coatings on Porous Titanium Alloy Scaffolds.

Up to now, how to implement the optimal regenerative repair of large load-bearing bone defects using artificial bone prosthesis remains to be an enormous challenge in clinical practice. Titanium-based alloys, especially Ti6Al4V, are applied as artificial bone grafts due to their favorable mechanical property and biocompatibility, assisted by personalized customization of 3D-printing to completely match with the bone defect. However, their bioinert peculiarity restricts osteointegration at the interface between bone and titanium-based implants and bone growth into porous titanium-based scaffolds, for lack of bone regeneration with the aid of blood vessels and neural networks.

Cavity oscillation drives pattern formation in early mammalian embryos.

During the second cell fate in mouse embryos, the inner cell mass (ICM) segregates into the spatially distinct epiblast (EPI) and primitive endoderm (PrE) layers. The mechanism driving this pattern formation, however, remains unresolved. Here, we report that, concomitant with the segregation process of EPI/PrE precursors starting from mid-blastocyst, the blastocyst cavity begins to oscillate cyclically with rapid contraction yet slow expansion, triggering a phase transition in the ICM to a fluid-like state.

Prognosis and fertility of stage II to IV borderline ovarian tumors after fertility-sparing surgery.

Objective: To evaluate the prognosis and fertility of patients with stage II to IV borderline ovarian tumors who underwent fertility-sparing surgery.

Methods: This retrospective single-institution study included patients aged <40 years with stage II to IV borderline ovarian tumors at the First Affiliated Hospital of Zhengzhou University between January 2007 and March 2023. The primary outcome was disease-free survival.

Universal Gas-Sensitive Detection of Various Lithium-Ion Battery Electrolyte Leakages via Ag@AgO-Functionalized SnO Nanoflowers with Abundant Oxygen Vacancies.

Lithium-ion batteries (LIBs) provide many benefits, but trace electrolyte leakage can cause serious safety risks such as thermal runaway. Although gas sensors offer a potential solution, the complexity of electrolyte solvents in LIBs makes it challenging to develop sensing materials capable of universally detecting multiple solvent molecules. Here, Ag@AgO-functionalized SnO nanoflowers were synthesized using a self-template pyrolysis strategy for the sensitive detection of both common solvent molecules and widely used electrolytes.

Exploring and validating associations between six systemic inflammatory indices and ischemic stroke in a middle-aged and old Chinese population.

Background: Inflammation and maladaptive immune mechanisms have been substantiated as integral components in the critical pathological processes of the injury cascade in ischemic stroke (IS). This study aimed to explore the associations between six systemic inflammatory indices and IS in a Chinese population.

Methods: This was a case-control study based on the retrospective review of electronic medical records from two hospitals in Shandong Province, China.

Methane oxidation to ethanol by a molecular junction photocatalyst.

Methane, the main component of natural and shale gas, is a significant carbon source for chemical synthesis. The direct partial oxidation of methane to liquid oxygenates under mild conditions is an attractive pathway, but the inertness of the molecule makes it challenging to achieve simultaneously high conversion and high selectivity towards a single target product. This difficulty is amplified when aiming for more valuable products that require C-C coupling.

The high efficacy of claudin18.2-targeted CAR-T cell therapy in advanced pancreatic cancer with an antibody-dependent safety strategy.

Pancreatic cancer (PC) is one of the most lethal digestive system tumors. Claudin18.2 is highly expressed in PC tissue and could serve as a suitable target for CAR-T therapy.

Advancement of 3D biofabrication in repairing and regeneration of cartilage defects.

Three-dimensional (3D) bioprinting, an additive manufacturing technology, fabricates biomimetic tissues that possess natural structure and function. It involves precise deposition of bioinks, including cells, and bioactive factors, on basis of computer-aided 3D models. Articular cartilage injuries, a common orthopedic issue.

Thermodynamic performance of organic rankine cycle based pumped thermal energy storage system with different working fluids.

In the context of global efforts toward energy transition and carbon neutrality, thermal integrated pumped thermal energy storage (TIPTES) systems, especially those utilizing low-grade heat sources, have garnered significant attention due to their large capacity, flexibility, and environmental advantages. This paper explores a TIPTES system that harnesses industrial waste heat as a heat source. The system's heat pump (HP) subcycle and Organic Rankine Cycle (ORC) subcycle are equipped with regenerators to optimize system configuration and enhance efficiency.

Erythrocyte Fatty Acid Patterns Are Associated with Skeletal Muscle Mass in Chinese Children.

Background: Nutritional factors are important for skeletal muscle mass and grip strength development in children.

Objectives: This study aimed to investigate the relationship between erythrocyte membrane fatty acid patterns (FAPs) and skeletal muscle mass and grip strength in children.

Methods: A total of 452 children aged 6-9 y were included in this study.

Preparation of Cello-Oligosaccharides by Precise-Controlled Enzymatic Depolymerization and Its Amphiphilic Functionalization for High-Oil Load Emulsification.

Cello-oligosaccharides (COS) are gaining great attention for their prebiotic-like properties, e.g., boosting gut health by promoting beneficial bacteria and improving digestion.

Ancient engineers: The role of plateau pika in shaping ecological uniqueness and guiding plant diversity conservation in alpine grasslands.

Small burrowing herbivores play a crucial role in maintaining structure and function of grassland ecosystems. To date, our understanding of whether practicing ecological uniqueness can enhance plant diversity conservation under small herbivore disturbances remains limited. Here, we investigate the ecological uniqueness of plant communities, which include habitats disturbed and undisturbed by plateau pikas.

Engineered Magneto-Piezoelectric Nanoparticles-Enhanced Scaffolds Disrupt Biofilms and Activate Oxidative Phosphorylation in Icam1 Macrophages for Infectious Bone Defect Regeneration.

Infectious bone defects pose significant clinical challenges due to persistent infection and impaired bone healing. Icam1 macrophages were identified as crucial and previously unrecognized regulators in the repair of bone defects, where impaired oxidative phosphorylation within this macrophage subset represents a significant barrier to effective bone regeneration. To address this challenge, dual-responsive iron-doped barium titanate (BFTO) nanoparticles were synthesized with magnetic and ultrasonic properties.

Nanograin-enhanced surface-layer strengthening of 3D printed intervertebral cage induced by sandblasting.

3D-printed customized titanium alloy (Ti6Al4V, TC4) as load-bearing prostheses and implants, such as intervertebral cages, have been widely used in clinical practice. Native biological inertia and inadequate bone in-growth of porous titanium alloy scaffolds hampered their clinical application efficiency and then extended the healing period. To improve the osseointegration capacity of 3D-printed intervertebral cages, sandblasting was selected to execute their surface treatment.

Laccase based per- and polyfluoroalkyl substances degradation: Status and future perspectives.

Per- and polyfluoroalkyl substances (PFAS) with stable carbon-fluorine bonds are used in a wide range of industrial and commercial applications. Due to their extreme environmental persistence, PFAS have the potential to bioaccumulate, cause adverse effects, and present challenges regarding remediation. Recently, microbial and enzymatic reactions for sustainable degradation of PFAS have gained attention from researchers, although biological decomposition of PFAS remains challenging.

Changes in the triglyceride-glucose-body mass index estimate the risk of hypertension among the middle-aged and older population: a prospective nationwide cohort study in China in the framework of predictive, preventive, and personalized medicine.

Background: Hypertension is a major modifiable cause of cardiovascular diseases and premature death worldwide. The triglyceride-glucose-body mass index (TyG-BMI), as a novel indicator, has been proposed for assessing hypertension risk. Nevertheless, a paucity of studies has explored the predictive potential of dynamic TyG-BMI for hypertension.

Enhancing MoS Electronic Performance with Solid-State Lithium-Ion Electrolyte Contacts through Dielectric Screening.

The high electrical contact resistance at the metal-semiconductor interface hinders the practical application of two-dimensional (2D) semiconductor electronics in the postsilicon era. Conventional strategies toward Ohmic contact involve optimizing contact electrode materials. In this work, we utilize the band structure tunability of a 2D semiconductor by introducing a high dielectric constant gate dielectric to optimize the Schottky barrier height and width.