Am J Transl Res
November 2024
Objective: To systematically evaluate a recurrence risk prediction model for patients with Atrial Fibrillation (AF) following ablation, and to provide a reference for the model establishment and optimization.
Methods: Literature retrieval was conducted in databases including PubMed, Cochrane Library, EMbase, and Web of Science to collect studies on recurrence risk prediction models for AF patients following ablation. Study quality was assessed using Prediction Model Risk of Bias Assessment Tool, and a meta-analysis was performed using MedCalc statistical software.
The role of the monocyte marker CD14 in the regulation of obesity is increasingly recognized. Our observations indicated that Cd14 mice exhibited a leaner body shape compared to their wild type (WT) counterparts. And the loss of CD14 alleviated high-fat diet (HFD)-induced obesity in mice.
View Article and Find Full Text PDFMost of the sequenced plastomes of photosynthetic angiosperms exhibit conservation in size, gene content, gene order, and GC content. In contrast, the sequenced plastomes of Cypripedium are distinguished by genome size expansion, AT-biased base composition, structural variation, and a low substitution rate. Additionally, the impact of sequencing methods is seldom addressed in prior studies, and the species represented in these studies are underrepresented.
View Article and Find Full Text PDFBiogas yield in anaerobic digestion (AD) involves continuous and complex biological reactions. The traditional linear models failed to quantitatively assess the interactive effects of these factors on AD performance. To further explore the internal relationship between target variables and AD performance, this study developed four machine learning models to predict biogas yield and consider the interaction among various factors.
View Article and Find Full Text PDFInt Immunopharmacol
December 2024
Ibuprofen, a non-steroidal drug, is well known for its anti-inflammatory activity. The effects of ibuprofen on the polarization of macrophages are still not clear. Herein, we used THP-1 monocyte-derived macrophages to find that ibuprofen has inhibitory effects on the polarization of both classically activated M1 macrophages and alternatively activated M2 macrophages by downregulating NF-κB and JAK/STAT signaling pathways.
View Article and Find Full Text PDFUnderstanding the precise mechanism of BMSC (bone marrow mesenchymal stem cell) osteogenesis is critical for metabolic bone diseases and bone reconstruction. The histone-lysine N-methyltransferase 2D (KMT2D) acts as an important methyltransferase related with congenital skeletal disorders, yet the function of KMT2D in osteogenesis was unclear. Here we found that KMT2D expression was decreased in BMSCs collected from ovariectomized mice.
View Article and Find Full Text PDFExperimental studies on DNA transposable elements (TEs) have been limited in scale, leading to a lack of understanding of the factors influencing transposition activity, evolutionary dynamics, and application potential as genome engineering tools. We predicted 130 active DNA TEs from 102 metazoan genomes and evaluated their activity in human cells. We identified 40 active (integration-competent) TEs, surpassing the cumulative number (20) of TEs found previously.
View Article and Find Full Text PDFZhongguo Dang Dai Er Ke Za Zhi
May 2024
Objectives: To explore the value of metagenomic next-generation sequencing (mNGS) technology in the etiological diagnosis of sepsis in preterm infants following antibiotic use.
Methods: A retrospective analysis of medical records for 45 preterm infants with sepsis who were treated at Henan Provincial People's Hospital. All patients received antibiotic treatment for ≥3 days and underwent both blood culture and mNGS testing.
Maternal separation (MS) represents a profound early life stressor with enduring impacts on neuronal development and adult cognitive function in both humans and rodents. MS is associated with persistent dysregulations in neurotransmitter systems, including the serotonin (5-HT) pathway, which is pivotal for mood stabilization and stress-coping mechanisms. Although the novel cannabinoid receptor, GPR55, is recognized for its influence on learning and memory, its implications on the function and synaptic dynamics of 5-HT neurons within the dorsal raphe nucleus (DRN) remain to be elucidated.
View Article and Find Full Text PDFOver past decades, chiral amides and peptides have emerged as powerful and versatile compounds due to their various biological activities and interesting molecular architectures. Although some chiral condensation reagents have been applied successfully for their synthesis, the introduction of racemization-free methods of amino acid activation have shown lots of advantages in terms of their low cost and low toxicity. In this review, advancements in amide and peptide synthesis using racemization-free coupling reagents over the last 10 years are summarized.
View Article and Find Full Text PDFFlexible electronic products, with their characteristics of flexibility and wearability, have attracted significant attention and have become an important direction in the research and development of the electronics industry. Planar micro-supercapacitors (MSCs) with flexible composite electrodes can provide reliable energy support for these products, propelling their further development. The research employed a quick, effective, and environmentally friendly method of laser scribing to create shape-controllable flexible composite electrodes on composite films of Poly(3,4-ethylenedioxythiophene) and graphene oxide (PEDOT/GO), which were subsequently assembled into MSCs.
View Article and Find Full Text PDFThe precise molecular mechanism behind fetal growth restriction (FGR) is still unclear, although there is a strong connection between placental dysfunction, inadequate trophoblast invasion, and its etiology and pathogenesis. As a new type of non-coding RNA, circRNA has been shown to play a crucial role in the development of FGR. This investigation identified the downregulation of hsa_circ_0034533 (circTHBS1) in FGR placentas through high-sequencing analysis and confirmed this finding in 25 clinical placenta samples using qRT-PCR.
View Article and Find Full Text PDFGuipi wan (GPW) is a traditional Chinese medicine commonly used in clinical practice, typically to treat neurological diseases such as neurasthenia and traumatic brain injury. It may have positive effects on cerebral ischemia‒reperfusion injury (cI/R). This study aimed to assess the effects of GPW in a mouse model of cI/R and find its possible targets.
View Article and Find Full Text PDFMembrane fouling, critically determined by the interplay of interfacial interaction between foulant and membrane, is a critical impediment that limits application extension of electrodialysis (ED) process. In this study, the extended Derjaguin-Landau-Verwey-Overbeek (XDLVO) model and molecular simulation were performed to quantify the interaction energy barrier for revealing anion exchange membranes (AEMs) fouling mechanisms of calcium ions coexisted with natural organic matter (NOM) (sodium alginate, humic acid, and bovine serum albumin). The insight gained from DMol module was also utilized to interpret the adhesion process of NOM at the molecular level.
View Article and Find Full Text PDFAutism spectrum disorder (ASD) is a multifaceted neuropsychiatric condition for which effective drug therapy for core clinical symptoms remains elusive. Lotusine, known for its neuroprotective properties in the treatment of neurological disorders, holds potential in addressing ASD. Nevertheless, its specific efficacy in ASD remains uncertain.
View Article and Find Full Text PDFObjective: Several clinical studies have shown an association between polycystic ovary syndrome (PCOS) and asthma; however, the molecular link between these conditions remains unclear. In this study, we conducted a reanalysis and repurposing of existing databases in order to depict the common key genes, related signaling pathways, and similarity of the immune microenvironment between PCOS and asthma.
Methods: PCOS and asthma data sets were downloaded, and common signal pathways were identified by using gene set enrichment analysis.
Zika virus (ZIKV) has significant potential to cause future outbreaks due to insufficient countermeasures. The evolution of ZIKV in Southeast Asian countries remains poorly understood. The phylogenetic, phylogeographic network, and recombination analyses of 366 ZIKV complete genome sequences identified between 1947 and 2021 were performed and the amino acid variation landscape was determined to reveal the evolutionary characteristics.
View Article and Find Full Text PDFColloidal gold immunoassay is the most widely used method in the field of drug detection. However, this method often has poor quantitative identification ability and low analytical sensitivity, which is not suitable for the analysis of hair poisoning ingredients. In order to solve these limitations, we developed an immunochromatographic test strip for simultaneously screening multiple drugs in this study.
View Article and Find Full Text PDF() is involved in the recombining and repairing of organelle genomes and is essential for maintaining their stability. Previous studies indicated that the length of the gene varied greatly among species and detected species-specific partial gene duplications in . However, there are critical gaps in the understanding of the gene size expansion, and the extent of the partial gene duplication of remains unclear.
View Article and Find Full Text PDFMaternal protein malnutrition leads to liver dysfunction and increases susceptibility to nonalcoholic fatty liver disease in adult fetal growth restriction (FGR) offspring, yet the underlying mechanism remains unknown. Peroxisomes play vital roles in fatty acid β-oxidation (FAO) and detoxification of reactive oxygen species (ROS). Using a well-defined rat model, the peroxins (PEXs), fatty acid metabolic enzymes, and oxidase stress regulators were investigated in the liver of FGR offspring.
View Article and Find Full Text PDFAn effective combination of polyoxometalates (POMs) and porous materials is a feasible method to solve the homogeneity of POMs and synthesize extremely stable POM-based catalysts. Herein, by using simple mechanochemical synthesis, we fabricated a series of composites constructed by Keggin-POMs, -phenylenediamine (Pa-1), and 1,3,5-triformylphloroglucinol (Tp), which form a stable covalent organic framework (Keggin-POMs@TpPa-1). Notably, the different Keggin-POMs@TpPa-1 composites showed different catalytic effects on thioether oxidation reaction under mild conditions.
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