Dispersive wave propagation in disordered flexible fibers enhances stress attenuation.

We experimentally and computationally analyze impact-shock-induced stress wave propagation in packings of disordered flexible fibers. We find that dispersive wave propagation, associated with large stress attenuation, occurs much more prevalently in systems with larger fiber aspect ratios and moderate fiber flexibility. We trace these features to the microstructural properties of fiber contact chains and the energy-trapping abilities of deformable fibers.

Association of insulin resistance surrogates with disease severity and adverse outcomes in chronic thromboembolic pulmonary hypertension: a multicenter cohort study.

Background: Chronic thromboembolic pulmonary hypertension (CTEPH) is a severely progressive disease that leads to right heart failure and death. Previous studies have shown that diabetes and insulin resistance (IR) are closely related to pulmonary hypertension, but the role of IR in patients with CTEPH remains unexplored. In this study, we investigated the relationship between four insulin resistance indices and disease severity, hemodynamic parameters, and adverse outcomes in patients with CTEPH.

SIRT6 Ameliorates Cancer Cachexia-Associated Adipose Wasting by Suppressing TNFR2 Signalling in Mice.

Background: Cachexia is a wasting syndrome associated with imbalanced energy metabolism and loss of adipose and muscle tissues and contributes to morbidity and mortality in ageing as well as in patients with severe chronic diseases, including cancer. At present, there are no treatments addressing cachexia that have reached validation to be used in the clinic. In this study, we investigate the protective role of SIRT6, an important regulator of energy homeostasis and health preservation, against Lewis lung carcinoma (LLC)-induced cachexia.

[Analysis of the efficacy and safety profile of sofosbuvir/velpatasvir/voxilaprevir in the treatment of patients with chronic hepatitis C with failed DAAs therapy].

To explore the efficacy and safety profile of sofosbuvir/velpatasvir/voxilaprevir ± ribavirin (SOF/VEL/VOX±RBV) for salvage treatment of chronic hepatitis C patients who have failed direct-acting antivirals (DAAs). Patients with chronic hepatitis C who failed DAAs±RBV treatment and were treated in five hospitals in Chongqing, Guangdong, Guizhou, and Guangxi from January 2022 to December 2023 were included in this retrospective study. One or more courses of DAAs±RBV therapy were evaluated for all patients who had been previously treated.

The intricate ballet of inflammation and autophagy: Insights from Mycoplasma gallisepticum-infected HD11 cells.

Objectives: Mycoplasma gallisepticum (M. gallisepticum) infection often leads to inflammatory damage and immunosuppression. Macrophages play a crucial role as the primary immune defense in chickens, with their inflammatory response and autophagy levels critical.

A music structure analysis method based on beat feature and improved residual networks.

In response to the issues of insufficient audio feature representation and insufficient model generalization ability in music structure analysis methods, a music structure analysis method based on beat feature fusion and an improved residual network was designed. Music structure analysis (MSA) contains two tasks, boundary detection and segment labeling. Boundary detection and Segment labeling are expected to accurately divide music segments and clarify the function.

Adsorption of Ni(II) from Aqueous Solution by Wheat Straw Modified with Mercaptopropionyl Functional Groups.

Mercaptopropionyl wheat straw (MPWS) was prepared as an adsorbent by modifying wheat straw with mercaptopropionyl groups, and the ability of MPWS for the removal of Ni(II) from aqueous solution was examined. The removal of Ni(II) by using MPWS was identified through investigating the impacts of MPWS dosage, adsorption temperature, and adsorption time. Different models for the adsorption isotherm and kinetics were utilized to fit the experimental results and elucidate the mechanism of MPWS for Ni(II).

Boosting Sodium Storage in Pitch-Derived Hard Carbon via MgO Catalytic Preoxidation.

Pitch-based hard carbon (HC) materials at low cost and high carbon yield represent a promising anode for sodium-ion batteries. However, their limited capacity poses a significant challenge to their practical use. Here, we report a universal strategy to boost sodium storage of pitch-based HC materials via catalytic oxidation with magnesium oxide to produce a high-oxygen pitch.

Association between bisphenol A exposure and adiposity measures in children.

Bisphenol A (BPA) is a chemical that has adverse effects on human health and may cause childhood obesity. Nevertheless, the association between BPA exposure and adiposity measures in children remains controversial, especially in young children. A cross-sectional study was conducted on 208 randomly selected children 4 to 6 years old attending preschools in Guangzhou, China.

Effects of Serum Insulin and Insulin-Like Growth Factor 1 Levels on the Association between Fetal Growth and Per- and Polyfluoroalkyl Substance Exposure Based on a Nested Case-Control Study.

Insulin and insulin-like growth factor 1 (IGF1) play key roles in fetal growth and development. However, their roles in the association between fetal growth and perfluoroalkyl and polyfluoroalkyl substance (PFAS) exposure remain unclear. In this study, the levels of 34 PFAS, IGF1, and insulin were measured in 258 paired mother-infant serum samples collected from a nested case-control study in Maoming city.

Impact of bladder volume and bladder shape on radiotherapy consistency and treatment interruption in prostate cancer patients.

Background: To investigate the effect of bladder volume (BV) and bladder shape on consistency and treatment interruption in prostate cancer radiotherapy (RT).

Methods: A total of 275 patients who underwent radical prostate cancer RT in our institution from April 2015 to December 2022 were enrolled. Bladder height, bladder width, and bladder length were defined and recorded.

A comparison of the treatment outcome of Asherman's syndrome which developed within and outside the puerperal period: A matched cohort study.

Introduction: The outcome following hysteroscopy adhesiolysis of Asherman's syndrome in the puerperal period who appeared to do less well than the participants who developed the syndrome unrelated to child birth. As there is no literature to support or refute the observation, we decided to conduct a retrospective cohort study to compare the outcome of hysteroscopic adhesiolysis in women who developed Asherman's syndrome within or outside the puerperal period.

Material And Methods: This retrospective cohort study aimed to compare the outcome of hysteroscopic adhesiolysis in women who developed Asherman's syndrome within the puerperal period and women who developed the Asherman's syndrome outside the puerperal period.

Turning Residual Lithium Compounds into a Fluorinated Interface for a Water-Stable, Industrializable Prelithiated Micron-SiO Anode.

The implementation of carbon-coated microsized SiO (MSiO@C) materials in high energy density lithium-ion batteries (LIBs) is challenged by their low initial Coulombic efficiency (ICE), large volume expansion, and limited cycle life. Even though prelithiation is an effective strategy to enhance ICE, it will make the prelithiated MSiO@C (Li-MSiO@C) extremely sensitive to moisture. For industrial applications, it is important to develop chemically and electrochemically stable Li-MSiO@C with high ICE and good cycling performance.

Adult Socioeconomic Position Mediates the Association Between Childhood Socioeconomic Position and Later-Life Frailty Trajectory: A Nationally Representative Cohort Study.

Background And Objectives: Early-life risk factors influence the aging process in the short term and shape its trajectory in the long term. We aim to (1) explore the association between childhood socioeconomic position (cSEP) and frailty trajectories and (2) test whether adult socioeconomic position (aSEP) mediates the association between cSEP and frailty trajectories.

Research Design And Methods: We analyzed 4 waves of the China Health and Retirement Longitudinal Study data.

Efficacy and safety of combined Kahook Dual Blade goniotomy with phacoemulsification in Chinese patients with primary open angle glaucoma.

Aim: To report the one-year surgical outcome Kahook Dual Blade goniotomy combined with phacoemulsification (KDB-Phaco) in Chinese patients with primary open angle glaucoma (POAG).

Methods: This is a retrospective study included 43 eyes of 28 Chinese POAG patients with cataract who accepted KDB-Phaco and followed-up for 12mo. Intraocular pressure (IOP), glaucoma medications and surgical complications were recorded.

Transcriptome analysis of 3D4/21 cells expressing CSFV NS4B.

Classical swine fever (CSF) caused by classical swine fever virus (CSFV) has resulted in severe losses to the pig industry worldwide. CSFV non-structural protein 4B (NS4B) plays a crucial role in CSFV replication and pathogenicity. However, the function of NS4B is still limited during CSFV infection.

Maternal Exposure of SD Rats to Benzo[a]Pyrene Impairs Neurobehavior and Hippocampal Synaptic Ultrastructure in Offspring via Downregulating Synaptic-Associated Factors.

Benzo[a]pyrene (B[a]P) is a carcinogenic contaminant widely present in the environment. Recently, increasing studies have paid attention to the developmental neurotoxicity of B[a]P in offspring in their early life stages; however, the underlying molecular mechanisms have not been clearly elucidated. In this study, we aimed to evaluate the effects of prenatal B[a]P exposure on neurobehavior of pups during their brain growth spurt (BGS) period and also explore the potential underlying mechanisms.

Impact of Pre-Existing Frailty on Cardiotoxicity Among Breast Cancer Patients Receiving Adjuvant Therapy.

Background: Prior research suggests that breast cancer patients with a high burden of frailty may face an increased risk of cardiotoxicity.

Objectives: This study sought to examine the association between frailty and cardiotoxicity rates in female breast cancer patients receiving adjuvant therapy after surgery.

Methods: We analyzed data from the OneFlorida+ clinical research network, focusing on breast cancer patients treated with adjuvant chemotherapy and targeted therapy from 2012 to 2022.

Impact of oil phase volume fraction on the characteristics of w/o/w emulsions stabilized with alkali-heat-treated rice residue glutelin.

Rice residue glutelin was used as a raw material and modified using alkali-heat treatment to prepare water-in-oil-in-water (w/o/w) double emulsions with 2.5 % and 3.0 % protein content by one-step emulsification method.

Evaluation of Prognostic Risk Models Based on Age and Comorbidity in Septic Patients: Insights from Machine Learning and Traditional Methods in a Large-Scale, Multicenter, Retrospective Study.

Background: Age and comorbidity significantly impact the prognosis of septic patients and inform treatment decisions. To provide clinicians with effective tools for identifying high-risk patients, this study assesses the predictive value of the age-adjusted Charlson Comorbidity Index (ACCI) and its simplified version, the quick ACCI (qACCI), for mortality in septic patients.

Methods: This retrospective study included septic patients from four Chinese medical centers.

Degradation of circular RNA by the ribonuclease DIS3.

Features of circular RNAs (circRNAs) produced by back-splicing of eukaryotic exon(s) make them resistant to degradation by linear RNA decay machineries. Thus, a general circRNA degradation pathway under normal conditions has remained largely elusive. Here, we report that the endonucleolytic enzyme DIS3 is responsible for the degradation of circRNAs.

An RPA-CRISPR/Cas12a-assisted method for nucleic acid detection of Haemonchus contortus in sheep.

Haemonchus contortus (H. contortus), a highly pathogenic and blood-feeding nematode, could cause haemonchosis，resulting in tens of billions of dollars in production losses and significantly impacting the development of sheep husbandry. Rapid and accurate detection methods were particularly important for the prevention and control of haemonchosis.

Deformation monitoring and safety stability evaluation study of high-altitude limestone dumps.

We employed synthetic aperture radar interferometry (InSAR) to assess the slope stability of a high-altitude landfill in Sangri County, Shannan, Tibet. To address the unique climatic conditions of high-altitude regions, the InSAR deformation monitoring model was enhanced to mitigate the effects of temperature and rainfall. The accuracy of InSAR monitoring in high-elevation slopes was validated by comparison with GNSS RTK measurements.

A simple and efficient method of preparing patients with gastric cancer for abdominal MRI examination.

Purpose: This study aims to evaluate the advantages of administering 200 ml of 5% dextrose water in improving pre-examination training efficiency, examination efficiency, success rate, and image quality of MRI scans in patients with gastric cancer.

Method: This study included 122 gastric cancer patients who underwent upper abdominal MRI from March 2022 to March 2024. These patients were divided into two groups: a study group of which patients had 200 ml of 5% dextrose water before MRI scan (n = 59) and a control group with only routine preparations (n = 63).