Publications by authors named "Guo Xiaojing"
Background: The results of many large randomized clinical trials (RCTs) have transformed clinical practice in gastroesophageal reflux disease (GERD) and esophageal hiatal hernia (HH). However, research waste (i.e.
View Article and Find Full Text PDFNon-targeted screening (NTS) technology has been showing significant potential in identifying contaminants of emerging concern (CECs) in water and has attracted great attention in academia in recent years. It is a method that analyzes samples without pre-selecting substances, enabling the detection and identification of unknown compounds, which is crucial for environmental health and public protection. This study uses the Bibliometrix package in R 4.
View Article and Find Full Text PDFA four-dimensional phase-contrast magnetic resonance imaging sequence with respiratory-controlled adaptive k-space reordering (ReCAR-4DPC) offers potential benefits of improved scan efficiency and motion robustness. The purpose of this study was to evaluate the reproducibility of flow measurement using this technique and to compare hemodynamic metrics obtained to two-dimensional phase contrast MRI (2DPC)-derived metrics of the thoracic aorta. ReCAR-4DPC was performed with identical scan parameters in 15 healthy volunteers (6M,9F, mean [range] 37 [23-47] years) and 11 patients with thoracic aortic dissection (6M,5F, 56 [31-81] years) and acquisition time was recorded.
View Article and Find Full Text PDFBackground: The goal is to identify methylation sites linked to transmission and their impact on host gene expression and HBV spread, aiming to uncover new molecular targets for preventing and treating intrauterine HBV infection.
Methods: This study recruited 1205 infants born to HBsAg-positive mothers in Liuzhou City, China, between July 2023 and January 2024. Infants were followed up at 7-12 months of age and classified as HBsAg-positive (case, n = 5) or HBsAg-negative (control, n = 14) based on serological testing.
Benign Glomus Tumor of the Urinary Bladder: A Case Report and Literature Review.
Int J Surg Pathol
December 2024
Article Synopsis
- * Imaging tests revealed a significant mass in the left bladder and a nonfunctional right kidney, leading to surgical removal of both the kidney and part of the bladder.
- * The final diagnosis was a bladder glomus tumor, and the patient remains healthy with no signs of recurrence after 15 months, underscoring the need for urologists to consider glomus tumors in their diagnostic process.
Causal association of physical activity with lymphoma risk: a Mendelian randomization analysis.
Eur J Public Health
November 2024
Article Synopsis
- * Findings indicated that higher levels of moderate-to-vigorous physical activity (MVPA) significantly lowered the risk of Hodgkin lymphoma and showed a weaker negative association with diffuse large B-cell lymphoma (DLBCL).
- * No causal relationship was found between physical activity and the risk of overall lymphoma, mature T/NK-cell lymphomas, or follicular lymphoma, emphasizing the specific impact on Hodgkin lymphoma and DLBCL.
Article Synopsis
- *The compound C210, a curcumin derivative, successfully increased EBV lytic activity in cancer cell lines without resulting in infectious virions, indicating a potential treatment pathway.
- *Research revealed that C210 works by inhibiting Hsp90, leading to the degradation of proteins that promote EBV lytic phase, suggesting it could enhance the effectiveness of other anticancer therapies like SAHA.
PD-1 inhibitor sintilimab treated patients with metastatic triple-negative breast cancer.
Front Cell Dev Biol
October 2024
Article Synopsis
- Triple-negative breast cancer (TNBC) poses significant treatment challenges, and this study aimed to evaluate the safety and effectiveness of the PD-1 inhibitor sintilimab in patients with metastatic TNBC using real-world data.
- A total of 40 patients (average age of 55.5) were treated with sintilimab, showing a median response duration of 2.8 months and an overall response rate of 22.5%, with median progression-free survival (PFS) of 3.5 months.
- Side effects were generally manageable; common issues included fatigue and skin rash, with a few severe cases noted, and 40% of patients had PD-L1-positive tumors, suggesting potential for enhanced treatment efficacy.
Article Synopsis
- * The study analyzed fecal samples from healthy controls, LTBI, and ATB patients, finding significant differences in gut bacterial diversity and microbial communities, with ATB patients showing notably reduced bacterial diversity.
- * Additionally, metabolic pathways related to purine and pyrimidine degradation were upregulated in LTBI and ATB patients, with specific metabolites identified that could distinguish between LTBI and healthy controls, indicating a link between gut microbiome changes and LTBI pathogenesis.
Article Synopsis
- Mechanical ventilation (MV) in critically ill pediatric patients can lead to diaphragmatic injury and dysfunction, assessed through diaphragm ultrasonography (DU).
- A study found that patients with severe ventilator induced diaphragmatic dysfunction (VIDD) had significantly longer durations of MV and PICU stays compared to those with non-severe VIDD.
- Daily DU monitoring indicated that severe VIDD typically began a few days after MV was initiated and was linked to poorer recovery outcomes, highlighting the need for early detection and management.
Article Synopsis
- Fat mass index (FMI) is an important measure of body fat that helps predict weight loss and quality of life after laparoscopic sleeve gastrectomy (LSG) in obese patients.
- A study analyzed data from 243 patients and found that FMI was a more accurate predictor of early eligible weight loss (EEWL) compared to other body composition metrics, with a significant cut-off point established at 13.662.
- Patients with lower FMI scores experienced greater weight loss and better quality of life outcomes, as indicated by higher BAROS scores, within the 24 months following surgery.
Article Synopsis
- Curcumin is known for its health benefits, but the impact of gut bacteria on its metabolism was previously under-researched.
- This study isolated two new bacterial strains (UMA_cur1 and UMA_cur2) from human stool samples that effectively convert curcumin into various metabolites.
- Notably, UMA_cur2 can produce unique compounds like hexahydro-curcumin and octahydro-curcumin, suggesting a complex interaction between curcumin and gut microbiota, with potential implications for its health effects.
Article Synopsis
- Bioactive components from Porphyra tenera (PT) have potential health benefits, particularly in relation to inflammatory bowel disease (IBD), which has not been thoroughly researched.
- A study with DSS-treated mice showed that PT supplementation reduced colitis severity by improving disease activity, repairing colonic damage, and lowering abnormal inflammation.
- Additionally, PT helped restore healthy gut microbiota and the production of beneficial short-chain fatty acids (SCFAs) and bile acids (BAs), suggesting edible seaweeds like PT could help prevent inflammation-related disorders in humans.
Article Synopsis
- * This means that the findings or claims in the article are no longer considered valid or trustworthy.
- * Readers should disregard the information presented in that article moving forward.
Article Synopsis
- The study aims to compare audio-vestibular function tests and gadolinium MRI in differentiating between definite Ménière disease (DMD) and probable Ménière disease (PMD) to help with early diagnosis and treatment.
- A total of 116 patients were assessed, showing that DMD patients had significantly worse hearing and higher rates of canal paresis and endolymphatic hydrops than PMD patients.
- The findings suggest that DMD and PMD could be different stages of the same disease, and using a combination of testing methods improves diagnostic accuracy, which is crucial for preserving inner ear function.
Article Synopsis
- DNA methylation is linked to folate levels and serves as a connection between developmental disorders and chronic diseases.
- Folic acid supplementation can influence DNA methylation in imprinted genes, which are essential for neonatal development and growth.
- This review highlights the relationship between imprinted genes, DNA methylation, and folic acid, aiming to summarize current research on their roles in growth and development.
Article Synopsis
- The study aimed to evaluate the effectiveness of an early rehabilitation program for VV-ECMO patients and its impact on respiratory and skeletal muscle function.
- Conducted in a comprehensive ICU, the research included measurements of various muscle parameters on multiple days after treatment for both a control group (usual rehab) and a study group (early rehab).
- The findings suggested that early rehabilitation led to less muscle atrophy and a shorter ECMO duration, indicating potential benefits of this approach for VV-ECMO patients.*
Article Synopsis
- Invasive micropapillary carcinoma (IMPC) of the breast is known for its aggressive characteristics like lymphovascular invasion and unique growth patterns, but its underlying molecular mechanisms are not well understood.* -
- This study investigated the roles of miR-30c and MTDH in IMPC through various experimental methods, finding that miR-30c acts as a tumor suppressor by inhibiting cell growth, invasion, and polarity changes by directly targeting MTDH.* -
- The research suggests that the miR-30c/MTDH axis could serve as both a therapeutic target and a prognostic biomarker for IMPC, highlighting its correlation with key clinical factors like tumor size and patient survival.*
Article Synopsis
- Histopathological tissue classification is important in computational pathology, and while deep learning models are effective, they face privacy concerns due to centralized training.
- Federated learning (FL) can protect privacy by keeping data local, but traditional FL approaches need lots of labeled data and multiple communication rounds, making them impractical in real-life situations.
- The proposed FedDBL framework addresses these challenges by allowing high classification performance with fewer samples and just one communication round, reducing data dependency and significantly improving efficiency while maintaining privacy and security.
Article Synopsis
- Interleukin-6 (IL-6) is a versatile cytokine that can promote both healing and inflammation in liver processes through three signaling modes: cis-, trans-, and cluster signaling.
- It helps liver regeneration and reduces inflammation, but can also contribute to negative effects like liver aging, fibrosis, and cancer.
- The review discusses therapeutic strategies targeting IL-6 and its receptors to switch its harmful effects to beneficial ones in treating inflammatory diseases and cancers.
Article Synopsis
- * The analysis included data from 972 patients across seven studies, revealing no significant difference in overall survival (OS) and adverse reactions (AR) between the two transplantation methods.
- * However, the results indicated that patients receiving allo-HSCT had a significantly longer progression-free survival (PFS) compared to those undergoing auto-HSCT, suggesting a potential advantage for allo-HSCT in this context.
Article Synopsis
- * The research identified DSCAM-AS1 as an mA-modified lncRNA that is overexpressed in breast cancer tissues, which correlates with poor clinical outcomes, and it was found to inhibit a type of cell death called ferroptosis.
- * Mechanistically, the study revealed that the mA methyltransferase METTL3 modifies both DSCAM-AS1 and the antioxidant gene SLC7A11, with DSCAM-AS1 enhancing SLC7A
Article Synopsis
- * A case was reported where this condition was accidentally found after the surgery, specifically linked to aorta cross-clamping.
- * The dissection was effectively managed through careful monitoring, using advanced 3D holographic and fluid dynamics analysis to guide treatment decisions.
Article Synopsis
- The probiotic strain G7, isolated from a healthy male, shows promise for promoting gastrointestinal health and reducing inflammation.
- In lab tests, G7 significantly inhibited inflammatory responses in macrophages and lessened colonic inflammation in mice treated with dextran sulfate sodium (DSS).
- Sequencing analysis indicated that G7 improved gut microbiota balance and altered bile acids and short-chain fatty acids (SCFAs), supporting its potential as a novel anti-inflammatory probiotic.