Near-Infrared Twisted Polycyclic Arene-Fused BisBODIPYs through a Tandem Inter- and Intramolecular Scholl Reaction.

Five novel polyaromatic-ring-fused bisBODIPYs have been synthesized from corresponding readily available α-arylBODIPYs through a FeCl-mediated tandem inter- and intramolecular oxidative aromatic coupling reaction. These resultant bisBODIPYs show twisted planar conformations, strong absorptions (ε up to 1.8 × 10 M cm), and good fluorescence emissions in the near-infrared region (NIR, 660-734 nm) and good intersystem crossing efficiencies (Φ = 18.

LncRNA gm40262 promotes liver fibrosis and parasite growth through the gm40262-miR-193b-5p-TLR4/Col1α1 axis.

Unlabelled: Alveolar echinococcosis (AE) is a severe and life-threatening parasitic disease caused by . Liver fibrosis is a significant pathological feature of advanced AE, characterized by the excessive production and accumulation of extracellular matrix (ECM). However, the precise underlying mechanism remains largely unknown.

Pore-Forming Protein LIN-24 Enhances Starvation Resilience in by Modulating Lipid Metabolism and Mitochondrial Dynamics.

The ability to survive starvation is a critical evolutionary adaptation, yet the molecular mechanisms underlying this capability remain incompletely understood. Pore-forming proteins (PFPs) are typically associated with immune defense, where they disturb the membranes of target cells. However, the role of PFPs in non-immune functions, particularly in metabolic and structural adaptations to starvation, is less explored.

Combined BRAF G469A mutation and echinoderm microtubule associated protein like-4-anaplastic lymphoma kinase rearrangement with resistance: A case report and review of literature.

Background: Through deeper understanding of targetable driver mutations in non-small-cell lung cancer (NSCLC) over the past years, some patients with driver mutations have benefited from the targeted molecular therapies. Although the anaplastic lymphoma kinase and BRAF mutations are not frequent subtypes in NSCLC, the availability of several targeted-drugs has been confirmed through a series of clinical trials. But little is clear about the proper strategy in rare BRAF G469A mutation, not to mention co-exhibition of anaplastic lymphoma kinase and BRAF G469A mutations, which is extremely rare in NSCLC.

Whole-Profile Soil Carbon Responses to Concurrent Warming and Precipitation Changes Across Global Biomes.

The joint effects of simultaneous warming and precipitation shifts on soil organic carbon (SOC)-the largest terrestrial carbon pool-remain poorly understood across large spatial extents. By evaluating a global dataset of SOC measurements in the top meter of soil through a space-for-change substitution approach, we show that, averaging across the globe, increased precipitation compensates for warming-induced SOC reductions regardless of soil depth and vice versa. Although additive effects between these two factors are predominant, negative interactive effects, which exacerbate SOC losses, are also common, particularly in tropical and subtropical grasslands/savannas and Mediterranean/montane shrublands.

Punicalagin ameliorates lipopolysaccharide-induced inflammatory response in dental pulp cells via inhibition of the NF-κB/Wnt5a-ROR2 pathway.

Introduction: Punicalagin (PCG) is a major polyphenolic component with potent anti-inflammatory, anti-atherogenic, anti-cancer, and antioxidant activities. This study aimed to investigate the impact and underlying mechanisms of PCG on lipopolysaccharide (LPS)-induced dental pulpitis.

Methods: A rat pulpitis model was constructed, and the infected pulp was covered with a PCG collagen sponge.

Pan‑cancer analysis of the oncogenic role of telomeric repeat binding factor 2 (TERF2) in human tumors and in vitro validation in gastric cancer by TERF2 knockdown.

Background: Telomeric repeat binding factor 2 (TERF2), a key component of the Shelterin complex, is crucial for maintaining telomere integrity and genome stability. While the involvement of TERF2 in tumorigenesis and progression has been documented, comprehensive pan-cancer analyses of TERF2 across different malignancies remain scarce.

Methods: In the present study, the expression, mutations, immune cell infiltration, and interacting genes of TERF2 were systematically evaluated through bioinformatics analysis, and in vitro experiments were performed to elucidate the functional roles of TERF2 in gastric cancer.

STING pathway activation with cisplatin polyprodrug nanoparticles for chemo-immunotherapy in ovarian cancer.

Cisplatin serves as the cornerstone medication in ovarian cancer (OC) chemotherapy; however, numerous resistance factors exist, resulting in unsatisfactory clinical treatment outcomes. Concurrently, OC frequently establishes an immunosuppressive microenvironment, which further exacerbates the challenges of cisplatin chemotherapy. Hence, it is particularly significant to explore a therapeutic approach capable of overcoming cisplatin resistance while reversing the immunosuppressive microenvironment of OC.

Design, Synthesis, and Biological Activity Evaluation of Novel Phenoxypyridine Derivatives Containing Acylthiourea Fragments as Protoporphyrinogen Oxidase Inhibitor Herbicides.

Protoporphyrinogen oxidase (PPO, EC 1.3.3.

Evaluation of stroke sequelae and rehabilitation effect on brain tumor by neuroimaging technique: A comparative study.

This study aims at the limitations of traditional methods in the evaluation of stroke sequelae and rehabilitation effect monitoring, especially for the accurate identification and tracking of brain injury areas. To overcome these challenges, we introduce an advanced neuroimaging technology based on deep learning, the SWI-BITR-UNet model. This model, introduced as novel Machine Learning (ML) model, combines the SWIN Transformer's local receptive field and shift mechanism, and the effective feature fusion strategy in the U-Net architecture, aiming to improve the accuracy of brain lesion region segmentation in multimodal MRI scans.

Toward Precision Dosing of Lamotrigine During Pregnancy: Physiologically Based Pharmacokinetic Modeling and Simulation.

Lamotrigine is a commonly used anti-seizure medication in pregnant women. However, its pharmacokinetics (PK) during pregnancy markedly change, increasing the frequency of seizures and endangering the safety of the mother and fetus. Meanwhile, insufficient PK data on lamotrigine during pregnancy hinders its dose adjustment.

LncRNA C2orf27A Promotes Gastric Cancer by Sponging MiR-610 and Elevating NOX4 Expression.

Long non-coding RNAs (lncRNAs) are crucial for gastric cancer (GC) progression. In this study, we aimed to investigate the function and molecular pathways of lncRNA C2orf27A in GC development. Bioinformatics databases, tissue cDNA microarrays, and cell lines were used to assess the expression of C2orf27A in GC.

Regulating cation-solvent interactions in PVDF-based solid-state electrolytes for advanced Li metal batteries.

Poly(vinylidene fluoride) (PVDF)-based solid-state electrolytes (SSEs) have been considered promising candidates for advanced Li metal batteries due to their adequate mechanical strength and acceptable thermal stability. However, the poor compatibility between residual solvent and Li metal inevitably leads to fast capacity decay. Herein, we propose a multifunctional cation-anchor strategy to regulate solvation chemistry in PVDF-based SSEs to boost the electrochemical performance of Li metal batteries.

Organoid models: applications and research advances in colorectal cancer.

This review summarizes the applications and research progress of organoid models in colorectal cancer research. First, the high incidence and mortality rates of colorectal cancer are introduced, emphasizing the importance of organoids as a research model. Second, this review provides a detailed introduction to the concept, biological properties, and applications of organoids, including their strengths in mimicking the structural and functional aspects of organs.

Nano-fiber/net artificial bionic dura mater promotes neural stem cell differentiating by time sequence external-oral administration to repair spinal cord injury.

The inflammatory microenvironment and resulting neuronal loss following spinal cord injury (SCI) impede the repair process. Endogenous neural stem cells (NSCs), which are constrained by neuroinflammation and slow differentiation rates, are unable to effectively facilitate recovery. In this study, coaxial electrospinning technology was employed to fabricate a nano-fiber/net artificial bionic dura mater (NABDM).

Cross-Ancestry Comparison of Aptamer and Antibody Proteomics Measures.

Measures from affinity-proteomics platforms often correlate poorly, challenging interpretation of protein associations with genetic variants (pQTL) and phenotypes. Here, we examined 2,157 proteins measured on both SomaScan 7k and Olink Explore 3072 across 1,930 participants with genetic similarity to European, African, East Asian, and Admixed American ancestry references. Inter-platform correlation coefficients for these 2,157 proteins followed a bimodal distribution (median r=0.

Upregulation of FMRP Is Involved in Neuropathic Pain by Regulating GluN2B Activation in Rat Spinal Cord.

Fragile X mental retardation protein (FMRP) has been proposed to play a potential role in the pathogenesis of autonomy and nociceptive paresthesia. However, the involvement of spinal FMRP in neuropathic pain remains unexplored. Using a rat model of neuropathic pain induced by chronic constriction injury (CCI), our investigation demonstrated an upregulation of FMRP at 3, 7, and 14 days post-CCI operation in the spinal dorsal horn (SDH).

Distribution and risk assessment of antibiotic resistance genes in swine farm wastewater and its surrounding environments: from soil to water.

Livestock farms are important reservoirs of antibiotic resistance genes (ARGs). However, how wastewater irrigation from swine farms affects the surrounding environments, especially water bodies, is not fully understood. In this study, the occurrence pattern and potential risk of ARGs and mobile gene elements (MGEs) in a biogas slurry from a large-scale swine farm and its surrounding environments were investigated.

Baicalin Prevents Chronic β-AR Agonist-Induced Heart Failure via Preventing Oxidative Stress and Overactivation of the NADPH Oxidase NOX2.

Heart failure (HF) remains the leading cause of mortality worldwide. Although various drugs are currently used in the treatment of HF, including angiotensin receptor blockers, angiotensin-converting enzyme inhibitors and beta blockers, none of these drugs can reverse the physiological remodelling of the heart associated with HF. Therefore, discovering novel drugs that can limit the extent of HF or prevent the structural dysfunction of the heart during HF progression is urgently needed.

Effects of Feeding on Insect Larvae Treated With Pesticide on the Biological and Biochemical Characteristics of Arma chinensis.

The effects of feeding on insect larvae treated with pesticide on the biological and biochemical characteristics of Arma chinensis were investigated. In the F generation, the developmental duration and preoviposition period were shortened, the average number of eggs laid was reduced, and the net reproductive rate and mean generation time were significantly lower in the treatment group compared to those in the control group. The average number of eggs laid by the F generation of A.

The association between non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio and hepatic steatosis and liver fibrosis among US adults based on NHANES.

Recently, the non-high-density to high-density lipoprotein cholesterol ratio (NHHR) has gained growing attention as an indicator for predicting diseases associated with lipid metabolism. Hepatic steatosis and fibrosis are tightly associated lipid metabolism. Our study aims to analyze the correlations among NHHR, hepatic steatosis, and fibrosis.

Alkaline phosphatase-mediated hydrolysis of dissolved organic phosphorus enhances phosphorus cycling in the Yellow Sea.

The utilization of dissolved organic phosphorus (DOP) driven by alkaline phosphatase hydrolysis contributes significantly to mitigating coastal nitrogen pollution through alleviating phosphorus (P) limitation. However, the lack of a parameterization for this process limits the quantitative assessment of its impact on marine nutrient pollution and cycling. Our study addresses this issue using data from a series of on-board microcosm experiments conducted in the Yellow Sea, where P limitation prevails.

Hesperidin alleviates endothelial cell inflammation and apoptosis of Kawasaki disease through inhibiting the TLR4/IĸBα/NF-ĸB pathway.

Kawasaki Disease (KD) is an acute and self-limiting vasculitis of unknown etiology that mainly occurs in infancy and can lead to vascular endothelial injury. Hesperidin (HES) is an economical dietary biological flavonoid with anti-oxidant, anti-inflammatory, and anti-apoptotic pharmacological effects. The main objective of this study was to investigate the protective effects of HES on KD, and try to elucidate the underlying mechanism.

Leaf metabolomic traits decipher the invasiveness of Alternanthera philoxeroides in urban wetlands.

Urbanisation has been considered to promote exotic plant invasion. Ecophysiology predicts phenotypic variation and potential evolution following urbanisation and can be used to evaluate plant invasiveness. However, few studies have included the role of ecophysiological traits for such invasiveness in urban ecosystems.

Suppression of FOXO3 by BMP signaling contribute to the different primordial germ cell proliferation between layers and broilers.

Although all domestic chicken breeds originate from their wild relatives, the red junglefowl, they have been selectively bred for high yields in egg or meat production， or both. Some breeds are highly efficient in egg production, while others perform poorly, due to long-term selection aimed for different purposes. Female primordial germ cells (PGCs) are the precursors of eggs and the population size of PGCs will ultimately determine ovarian reserve of hens.