Publications by authors named "Guo Wanshu"
Article Synopsis
- The study investigates the cognitive dysfunction linked to chronic cerebral hypoperfusion (CCH), a major cause of vascular dementia, and seeks effective therapy options.
- Bone marrow mononuclear cells (BMMNCs) were utilized in experiments to evaluate transfection efficiency and assess brain injury through various methods, including RT-qPCR and histological staining.
- Findings indicated significant neurological deficits, increased brain injury markers, and heightened neuronal apoptosis in CCH rat models, while treatment with BMP-PEI-Slit2/BMMNCs improved neurological function and highlighted the potential of this combination therapy.
The melanoma-associated antigen (MAGE) family found in eukaryotes plays a crucial role in cell proliferation and differentiation, spermatogenesis, neural development, etc. This study explored the validation and evolution of MAGE genes in eukaryotic genomes and their distribution and expression patterns in pigs. In total, 249 MAGE genes were found on 13 eukaryotic species.
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- The study investigates the relationship between age at first birth (AFB) and depression, specifically focusing on major depressive disorder and postpartum depression.
- The researchers utilized Mendelian randomization techniques, analyzing public data from genome-wide association studies, to determine the causal effects of AFB on depression-related outcomes.
- The findings suggest that older age at first birth is linked to a reduced risk of major depressive disorder, demonstrating a significant causal association validated by various statistical methods.
Article Synopsis
- The study aimed to assess how antagonists of Toll-Like Receptors (TLR2, TLR4) affect cerebrovascular disease (CSVD) using a stroke-induced renovascular hypertension rat model.
- The administration of TLR2 and TLR4 antagonists improved cognitive function and reduced white matter injury, while also decreasing inflammation and oxidative stress markers in the rat models after stroke.
- Findings indicated that the protective effects of TLR2 and TLR4 antagonists operate through the PI3K/Akt/GSK3β signaling pathway, enhancing cell viability and inhibiting apoptosis.
Article Synopsis
- EGCG shows potential neuroprotective effects against brain injury in rat models of MCAO by reducing neurological deficits and preventing neuronal apoptosis.
- The study utilized various methods including HE staining and ELISA to measure the impact of EGCG on oxidative stress and neuronal health.
- Results suggest that the protective effects of EGCG are linked to the modulation of the PI3K/AKT/eNOS signaling pathway, highlighted by changes in apoptosis-related proteins.
Article Synopsis
- The aggregation of amyloid β-peptide (Aβ) is linked to Alzheimer's disease progression, and a new DNA vaccine, p(Aβ3-10)10-mIL-4, has been developed as a potential treatment.
- Immunization of APP/PS1 transgenic mice with this vaccine resulted in high levels of anti-Aβ antibodies, reduced behavioral impairments, and decreased Aβ deposits in the brain, indicating improved cognitive function.
- The immune response was characterized by a Th2 anti-inflammatory profile, suggesting that the vaccine not only lessened Aβ accumulation but also reduced inflammation, making it a promising therapy for Alzheimer's disease.
Article Synopsis
- Researchers immunized three-month-old Alzheimer's disease model mice with a specific vaccine via nasal inhalation and found increases in Aβ42 antibody levels in the treated groups.
- The vaccine AdCpG-(Aβ3-10)10 triggered significant splenocyte proliferation and modified cytokine levels, increasing IL-4 and IL-10 while decreasing IL-2 and interferon-γ in the AdCpG(Aβ3-10)10 group.
- Overall, the study suggests that this vaccine elicits a strong humoral immune response while minimizing T cell-mediated cytotoxicity associated with Aβ1-42.
A new DNA vaccine fused with the C3d-p28 induces a Th2 immune response against amyloid-beta.
Neural Regen Res
September 2013
Article Synopsis
- Researchers developed a DNA vaccine called p(Aβ3-10)10-C3d-p28.3 to improve the immune response against amyloid-beta (Aβ), a protein linked to Alzheimer's disease.
- The vaccine was tested in female C57BL/6J mice, showing it successfully produced high levels of anti-Aβ antibodies that effectively bound to Aβ plaques in brain tissue.
- Results indicate that the vaccine triggered a Th2 immune response with favorable safety, suggesting it could be a promising treatment option for Alzheimer's disease.
Article Synopsis
- Developed a plasmid DNA vaccine targeting Alzheimer's disease, using Aβ3-10 and a molecular adjuvant, administered to mice.
- The vaccine triggered a Th2 immune response, producing anti-Aβ antibodies and leading to improved cognitive function.
- Results showed a reduction in Aβ buildup and astrocytosis without increasing microhemorrhage risk, indicating the vaccine's potential as a treatment option.
Article Synopsis
- Active immunization shows potential for Alzheimer's treatment, but issues like T-lymphocyte infiltration need to be addressed.
- A new vaccine, p(Aβ3-10)10-MT, was developed using a synthesized form of Aβ and melatonin, which successfully induced high levels of anti-Aβ antibodies in mice.
- The vaccine not only lowered Aβ deposits and improved cognitive function but also prompted a beneficial immune response, indicating its potential as an effective treatment for Alzheimer's disease.