Objective: To observe the effect of electroacupuncture(EA) on glucagon-like peptide-1 receptor (GLP-1R)/ phosphatidylinositol 3-kinase (PI3K)/ protein kinase B(Akt) protein pathway in the substantia nigra of mice with Parkinson's di-sease (PD),so as to explore its underlying mechanisms in treatment of PD.
Methods: Forty-eight C57BL/6 male mice were randomly divided into normal, model, EA and inhibitor groups, with 12 mice in each group. PD mouse model was established by intragastrical administration of rotenone for 4 weeks.
At present, how to increase insulin rapidly, availably and stably is still a conundrum in the treatment of diabetes mellitus. studies have shown that insulin can be released from hydrogel-nanogel composite according to the changes of glucose level. This study aimed to observe the glucose-lowering effects and evaluate the safety of the insulin-loaded hydrogel-nanogel composite in diabetic rats.
View Article and Find Full Text PDFDiabetes mellitus (DM) is a potential etiology of disc degeneration. Glucagon-like peptide-1 (GLP-1) is currently regarded as a powerful treatment option for type 2 diabetes. Apart from the beneficial effects on glycaemic control, GLP-1 has been reported to exert functions in a variety of tissues on modulation of cell proliferation, differentiation, and apoptosis.
View Article and Find Full Text PDFBackground: The activation of mitogen-activated protein kinases (MAPKs) have been observed in synaptic plasticity processes of learning and memory in neuropathic pain. Cerebrospinal fluid-contacting nucleus (CSF-CN) has been identified with the onset and persistence of neuropathic pain. However, whether extracellular signal-regulated protein kinase 5 (ERK5), a member of MAPKs, in CSF-CN participates in neuropathic pain has not been studied yet.
View Article and Find Full Text PDFBackground: Visceral adipose tissue (VAT) is a unique pathogenic fatty deposit, in that it is closely correlated with risk of cardiovascular diseases. The present study is to investigate the usefulness of neck circumference (NC) to indicate VAT.
Methods: Participants aged 35 to 75 years who had taken abdomen and neck computer tomography (CT) examination were included in this study.
Zhonghua Liu Xing Bing Xue Za Zhi
October 2010
Objective: To determine the efficient cut-off points of fasting fingertip blood glucose test for undiagnosed diabetes mellitus (DM), impaired glucose tolerance (IGT), and impaired fasting glucose (IFG) in community-based residents aged above 45 years old.
Methods: A cluster-randomized study was conducted from May 2008 to January 2009. A total of 3250 subjects aged above 45 years in two communities of Baoding city received questionnaire investigation and tested for fingertip blood glucose.
Zhonghua Liu Xing Bing Xue Za Zhi
December 2009
Objective: To recognize the main risk factors and to provide evidence for prevention and intervention of type 2 diabetes chronic complications.
Methods: A hospital-based frequency matched case-control study including 200 type 2 diabetes mellitus (T2DM) chronic complications cases and 200 controls without T2DM chronic complications was carried out in Baoding city. Relationships between factors and T2DM chronic complications were analyzed by non-conditional uni-variate and multivariate logistic regression methodologies.
Aim: To describe the rates and patterns of unintentional injuries among primary and middle school students in China.
Methods: A cross-sectional survey was conducted in Maanshan City of the Anhui Province in eastern China. All students attending six primary and four middle schools, selected randomly, were asked to report unintentional injuries occurring in the 12-mo period before the survey.
Objective: To describe the rate and pattern of unintentional school injuries among primary and middle school students and to explore the major risk factors involved.
Study Design: A cross-sectional survey of more than 10,000 students attending 6 primary and 4 middle schools selected randomly from all schools in Maanshan City of Anhui Province in eastern China was conducted to collect information on school injuries occurring in the 12-month period before the survey. Rate ratios for risk factors were estimated using the negative binomial regression analysis.
Zhonghua Liu Xing Bing Xue Za Zhi
March 2004
Objective: To probe into the effects of familial factors on injury-related behaviors in children.
Methods: Injury-related behaviors and familial factors of 6884 children were investigated with Family Questionnaire and Child Behavior Checklist. Multi-nominal logistic regression analysis was performed.