TMP: Temporal Motion Propagation for Online Video Super-Resolution.

Online video super-resolution (online-VSR) highly relies on an effective alignment module to aggregate temporal information, while the strict latency requirement makes accurate and efficient alignment very challenging. Though much progress has been achieved, most of the existing online-VSR methods estimate the motion fields of each frame separately to perform alignment, which is computationally redundant and ignores the fact that the motion fields of adjacent frames are correlated. In this work, we propose an efficient Temporal Motion Propagation (TMP) method, which leverages the continuity of motion field to achieve fast pixel-level alignment among consecutive frames.

The effects of parent-child separation on the digital literacy of children and adolescents: A bidirectional perspective study.

From a bidirectional perspective, the present cross-sectional study explored the impacts of parent-child separation on the digital literacy of children and adolescents. Drawing upon data from 1894 students (12-18 years, 49.33 % females) in Nanling county, China, we found that parent-child separation can negatively affect the digital literacy of children and adolescents, but effects differ between children experiencing parental migration or parental divorce.

Development of an Imidazopyridazine-Based MNK1/2 Inhibitor for the Treatment of Lymphoma.

The mitogen-activated protein kinase-interacting protein kinases (MNKs) are the only kinases known to phosphorylate eukaryotic translation initiation factor 4E (eIF4E) at Ser209, which plays a significant role in cap-dependent translation. Dysregulation of the MNK/eIF4E axis has been found in various solid tumors and hematological malignancies, including diffuse large B-cell lymphoma (DLBCL). Herein, structure-activity relationship studies and docking models determined that exhibits excellent MNK1/2 inhibitory activity, stability, and hERG safety.

Design, synthesis and biological evaluation of MNK-PROTACs.

Mitogen-activated protein kinase (MAPK)-interacting kinases (MNKs) can regulate cellular mRNA translation by controlling the phosphorylation of the eukaryotic translation initiation factor 4E (eIF4E), which plays an important role in tumor initiation, development, and metastasis. Although small-molecule MNK inhibitors have made significant breakthroughs in the treatment of various malignancies, their clinical application can be limited by drug resistance, target selectivity and other factors. The strategy of MNK-PROTACs which selectively degrades MNK kinases provides a new approach for developing small-molecule drugs for related diseases.

Ecto-nucleotide pyrophosphatase/phosphodiesterase 1 inhibitors: Research progress and prospects.

The cancer immunotherapies involved in cGAS-STING pathway have been made great progress in recent years. STING agonists exhibit broad-spectrum anti-tumor effects with strong immune response. As a negative regulator of the cGAS-STING pathway, ecto-nucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) can hydrolyze extracellular 2', 3'-cGAMP and reduce extracellular 2', 3'-cGAMP concentration.

Electrically Driven Site-Controlled Single Photon Source.

Single photon sources are fundamental building blocks for quantum communication and computing technologies. In this work, we present a device geometry consisting of gold pillars embedded in a van der Waals heterostructure of graphene, hexagonal boron nitride, and tungsten diselenide. The gold pillars serve to both generate strain and inject charge carriers, allowing us to simultaneously demonstrate the positional control and electrical pumping of a single photon emitter.

Text Prior Guided Scene Text Image Super-resolution.

Scene text image super-resolution (STISR) aims to improve the resolution and visual quality of low-resolution (LR) scene text images, while simultaneously boost the performance of text recognition. However, most of the existing STISR methods regard text images as natural scene images, ignoring the categorical information of text. In this paper, we make an inspiring attempt to embed text recognition prior into STISR model.

Distinctive -Factor of Moiré-Confined Excitons in van der Waals Heterostructures.

We investigated the valley Zeeman splitting of excitonic peaks in the microphotoluminescence (μPL) spectra of high-quality hBN/WS/MoSe/hBN heterostructures under perpendicular magnetic fields up to 20 T. We identify two neutral exciton peaks in the μPL spectra; the lower-energy peak exhibits a reduced -factor relative to that of the higher energy peak and much lower than the recently reported values for interlayer excitons in other van der Waals (vdW) heterostructures. We provide evidence that such a discernible -factor stems from the spatial confinement of the exciton in the potential landscape created by the moiré pattern due to lattice mismatch or interlayer twist in heterobilayers.

All-optical control of spin in a 2D van der Waals magnet.

Two-dimensional (2D) van der Waals magnets provide new opportunities for control of magnetism at the nanometre scale via mechanisms such as strain, voltage and the photovoltaic effect. Ultrafast laser pulses promise the fastest and most energy efficient means of manipulating electron spin and can be utilized for information storage. However, little is known about how laser pulses influence the spins in 2D magnets.

To Study the Effect of Individualized Nursing Model Based on MDT Concept on Limb Function Recovery and Quality of Life in Patients with Breast Cancer.

Objective: To study the value of the individualized nursing model based on the concept of multidisciplinary team (MDT) on recovery of limb function and quality of life in patients with breast cancer.

Methods: A total of 110 breast cancer patients admitted to our hospital from January 2021 to December 2021 were selected as the research objects. The 110 breast cancer patients were divided into the research group ( = 55) and the control group ( = 55) according to the random number table method.

Combined Photothermal and Photodynamic Therapy for Cancer Treatment Using a Multifunctional Graphene Oxide.

Graphene oxide (GO) is one of the most studied nanomaterials in many fields, including the biomedical field. Most of the nanomaterials developed for drug delivery and phototherapies are based on noncovalent approaches that lead to an unspecific release of physisorbed molecules in complex biological environments. Therefore, preparing covalently functionalized GO using straightforward and versatile methods is highly valuable.

Lateral dimension and amino-functionalization on the balance to assess the single-cell toxicity of graphene on fifteen immune cell types.

Given the wide variety of potential applications of graphene oxide (GO), its consequent release into the environment poses serious concerns on its safety. The future production and exploitation of graphene in the years to come should be guided by its specific chemical-physical characteristics. The unparalleled potential of single-cell mass cytometry (CyTOF) to dissect by high-dimensionality the specific immunological effects of nanomaterials, represents a turning point in nanotoxicology.

2D Materials and Primary Human Dendritic Cells: A Comparative Cytotoxicity Study.

Human health can be affected by materials indirectly through exposure to the environment or directly through close contact and uptake. With the ever-growing use of 2D materials in many applications such as electronics, medical therapeutics, molecular sensing, and energy storage, it has become more pertinent to investigate their impact on the immune system. Dendritic cells (DCs) are highly important, considering their role as the main link between the innate and the adaptive immune system.

Spatial Effect Analysis of Health Expenditure and Health Output in China From 2011 to 2018.

Objective: The objective of this study is to study the spatial effects of health expenditure and health output in China.

Methods: Using the spatial panel data of 31 provinces in China from 2011 to 2018, the spatial weight matrix was introduced to analyze the spatial correlation, and the spatial Durbin model (SDM) was used to investigate the health output effect of health expenditure.

Results: Excluding the number of doctors per thousand, the provincial health expenditure, the number of beds per thousand population, and per capita education level had a positive impact on the regional health output.

Excited State Spectroscopy of Boron Vacancy Defects in Hexagonal Boron Nitride Using Time-Resolved Optically Detected Magnetic Resonance.

We report optically detected magnetic resonance (ODMR) measurements of an ensemble of spin-1 negatively charged boron vacancies in hexagonal boron nitride. The photoluminescence decay rates are spin-dependent, with intersystem crossing rates of 1.02 ns and 2.

Graphene oxide activates B cells with upregulation of granzyme B expression: evidence at the single-cell level for its immune-modulatory properties and anticancer activity.

We recently found by single-cell mass cytometry that human B cells internalize graphene oxide (GO). The functional impact of such uptake on B cells remains unexplored. Here, we disclosed the effects of GO and amino-functionalized GO (GONH) interacting with human B cells and at the protein and gene expression levels.

Exploring the Value of Radiomics Features Based on B-Mode and Contrast-Enhanced Ultrasound in Discriminating the Nature of Thyroid Nodules.

Background: With the improvement of ultrasound imaging resolution and the application of various new technologies, the detection rate of thyroid nodules has increased greatly in recent years. However, there are still challenges in accurately diagnosing the nature of thyroid nodules. This study aimed to evaluate the clinical application value of the radiomics features extracted from B-mode ultrasound (B-US) images combined with contrast-enhanced ultrasound (CEUS) images in the differentiation of benign and malignant thyroid nodules by comparing the diagnostic performance of four logistic models.

Electrical and optical properties of transition metal dichalcogenides on talc dielectrics.

Advanced van der Waals (vdW) heterostructure devices rely on the incorporation of high quality dielectric materials which need to possess a low defect density as well as being atomically smooth and uniform. In this work we explore the use of talc dielectrics as a potentially clean alternative substrate to hexagonal boron nitride (hBN) for few-layer transition metal dichalcogenide (TMDC) transistors and excitonic TMDC monolayers. We find that talc dielectric transistors show small hysteresis which does not depend strongly on sweep rate and show negligible leakage current for our studied dielectric thicknesses.

Joint Denoising and Demosaicking With Green Channel Prior for Real-World Burst Images.

Denoising and demosaicking are essential yet correlated steps to reconstruct a full color image from the raw color filter array (CFA) data. By learning a deep convolutional neural network (CNN), significant progress has been achieved to perform denoising and demosaicking jointly. However, most existing CNN-based joint denoising and demosaicking (JDD) methods work on a single image while assuming additive white Gaussian noise, which limits their performance on real-world applications.

Reaction between Graphene Oxide and Intracellular Glutathione Affects Cell Viability and Proliferation.

Graphene oxide (GO) is currently developed for biomedical applications as a promising nanoplatform for drug delivery, phototherapy, and biosensing. As a consequence, its safety and cytotoxicity issues have attracted extensive attention. It has been demonstrated that GO causes an increase of intracellular oxidative stress, likely leading to its cytotoxicity and inhibition of cell proliferation.

Blood Eosinophils and Clinical Outcome of Acute Exacerbations of Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-Analysis.

Background: Numerous studies have shown the association between eosinophilia and clinical outcomes of patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). But the evidences are lack of consensus.

Objective: The aim of this meta-analysis was to conduct a pooled analysis of outcome comparing eosinophilic (EOS) AECOPD and non-EOS AECOPD patients.

Correction: Controlled functionalization of carbon nanodots for targeted intracellular production of reactive oxygen species.

Correction for 'Controlled functionalization of carbon nanodots for targeted intracellular production of reactive oxygen species' by Ding-Kun Ji et al., Nanoscale Horiz., 2020, 5, 1240-1249, DOI: .

Is carboxylation an efficient method for graphene oxide functionalization?

Graphene oxide (GO) is one of the most popular materials applied in different research areas thanks to its unique properties. The application of GO requires well-designed protocols to introduce different functionalities on its surface, exploiting the oxygenated groups already present. Due to the complex and unstable chemical environment on the GO surface, it is recommended to perform the functionalization under mild conditions.