Research Question: What role, if any, does the extent of lesional fibrosis play in impaired glycolysis leading to adenomyosis-associated heavy menstrual bleeding (ADM-HMB)?
Design: Forty-eight patients with ADM-HMB were recruited, among them 25 reported moderate to heavy bleeding (MHB), and the remaining 23, excessive bleeding (EXB). The full-thickness uterine tissue columns were processed for Masson trichrome staining and immunohistochemistry analyses. The expression levels of HIF-1α, GLUT1, HK2, PFKFB3 and PKM2 proteins that are critically involved in glycolysis in endometrial epithelial cells cultured on substrates of different stiffness, and the levels of glycolysis were quantitated.
Fluorinated or fluoroalkylated alcohols are common structural motifs in biologically active molecules, natural products, and pharmaceuticals. However, pentafluorosulfanyl (SF) alcohols, a unique class of SF compounds that serve as synthetically valuable building blocks, are difficult to prepare with current methodologies. In this article, we present a single-step, metal-free, and photo-induced hydroxypentafluorosulfanylation of styrenes or α,β-unsaturated esters/amide, producing a series of structurally diverse pentafluorosulfanyl alcohols with up to 89% yields.
View Article and Find Full Text PDFTwo-dimensional (2D) ion crystals may represent a promising path to scale up qubit numbers for ion trap quantum information processing. However, to realize universal quantum computing in this system, individually addressed high-fidelity two-qubit entangling gates still remain challenging due to the inevitable micromotion of ions in a 2D crystal as well as the technical difficulty in 2D addressing. Here we demonstrate two-qubit entangling gates between any ion pairs in a 2D crystal of four ions.
View Article and Find Full Text PDFBackground: Bisphosphonates (BPs) are the first-line treatment to stop bone resorption in diseases, including osteoporosis, Paget's disease, multiple myeloma and bone metastases of cancer. However, BPs-related osteonecrosis of the jaw (BRONJ), characterized by local inflammation and jawbone necrosis, is a severe intractable complication. The cumulative inflammatory burden often accompanies impaired lymphatic drainage, but its specific impact on BRONJ and the underlying mechanisms remain unclear.
View Article and Find Full Text PDFThe flowers of Abelmoschus manihot (L.) Medic are commonly used in clinical practice in China to cure forms of chronic kidney disease. Despite a long history of traditional use, the flowers obtained by different drying technologies have never been fully chemically characterized, and the ranges of constituents between different drying methods have not been comprehensively reported.
View Article and Find Full Text PDFrhizomes have been applied as traditional medicinal materials for thousands of years. In China, f. (red flower and stem, Ge), f.
View Article and Find Full Text PDFBreast neuroendocrine carcinoma (NECB) is a rare type of breast tumor. Large-cell neuroendocrine carcinomas of the breast (LCNECB) are a special and rare histological subtype of NECB. Here, we present a case of a 59-year-old woman who was diagnosed with an LCNECB.
View Article and Find Full Text PDFDense lithium hydride (LiH) is widely used in neutron shielding applications for thermonuclear reactors and space systems due to its unique properties. However, traditional sintering methods often lead to cracking in LiH products. This study investigates the densification sintering of LiH using microwave technology.
View Article and Find Full Text PDFBorani () has garnered significant attention due to its abundant nutritional quality. Datong, located in Shanxi Province, is recognized as one of the four major production regions for high-quality . While Datong boasts multiple production areas, the nutritional composition of daylilies varies across regions due to environmental factors and planting patterns, which remain unclear.
View Article and Find Full Text PDFWith the population ages, many patients are unable to receive comprehensive care, leading to an increase in hazardous incidents, particularly falls occurring after getting out of bed. To address this issue, this paper proposes a method for recognizing bed-exit intentions using an array air spring mattress. The method integrates convolutional neural networks with feature point matching techniques to identify both global and local features of the array air spring.
View Article and Find Full Text PDFInorganic arsenic (iAs) is a persistent bioaccumulation carcinogen that is most abundant in soils in the form of arsenite-As (III) and arsenate-As (V). However, there is currently very little explicit evidence about cytotoxicity of As on soil organisms. Moreover, toxicological data for iAs and proteotoxicity is shortage.
View Article and Find Full Text PDFJ Colloid Interface Sci
February 2025
Black phosphorus (BP) has been highly regarded as a favourable candidate for fast-charging anode applications owing to its high theoretical capacity and advantageous charge-discharge platform. However, BP faces challenges related to compromised electrochemical performance resulting from an unstable solid-electrolyte interface (SEI) and substantial volumetric expansion. This study proposes the engineering of an inorganic-dense SEI on the surface of BP-C through the strategic incorporation of lithium fluoride (LiF).
View Article and Find Full Text PDFStrain engineering plays a crucial role in activating the basal plane of the TMD catalysts. However, experimental evidence linking strain strength to activity and distinguishing effects of compressive and tensile strain remains elusive due to the absence of high-resolution correlation techniques. Here, we utilize nanobubble imaging by on-chip total-internal reflection microscopy to visualize active sites on the basal plane of strained MoS during hydrogen evolution reaction and atomic force microscopy to correlatively capture the nanoscale morphology and strain maps.
View Article and Find Full Text PDFThe emergence of monkeypox has become a global health threat after the COVID-19 pandemic. Due to the lack of available specifically treatment against MPV, developing an available vaccine is thus the most prospective and urgent strategy. Herein, a programmable macrophage vesicle based bionic self-adjuvanting vaccine (AM@AEvs-PB) is first developed for defending against monkeypox virus (MPV).
View Article and Find Full Text PDFFollowing the publication of this paper, a concerned reader drew to the Editor's attention that it appeared as if the authors had calculated the apoptotic rates erroneously. The authors were asked to provide an explanation to account for the concerns raised by the interested reader; however, they did not respond to this request submitted by the Editorial Office. Therefore, owing to the lack of responsiveness on the part of the authors, the Editor of has decided that this paper should be retracted from the journal.
View Article and Find Full Text PDFFrozen shoulder (FS) is characterized by the thickening and fibrosis of the joint capsule, leading to joint contracture and a reduction in joint volume. The precise etiology responsible for these pathological changes remains elusive. Therefore, the primary aim of this study was to explore the potential involvement of pathogenic genes in FS and analyze their underlying roles in the disease progression.
View Article and Find Full Text PDFTo generate and manipulate spin-polarized electronic states in solids are crucial for modern spintronics. The textbook routes employ quantum well states or Shockley/topological type surface states whose spin degeneracy is lifted by strong spin-orbit coupling and inversion symmetry breaking at the surface/interface. The resultant spin polarization is usually truncated because of the intertwining between multiple orbitals.
View Article and Find Full Text PDFAngew Chem Int Ed Engl
November 2024
Climate change driving by greenhouse gas emissions from petroleum-based energy has garnered significant attention. Renewable energy production via a sustainable system that integrates the cell factory and visible-light-driven photocatalysts offers a novel approach for upcycling methane and addressing global energy challenges. Here, an auto-activated biohybrid system driven by solar energy is developed for converting methane into hydrogen fuel, which incorporated thienoviologen (S-MV) and genetically engineered methanotrophic bacteria.
View Article and Find Full Text PDFIt is urgent to develop an ultrasensitive formaldehyde (HCHO) sensor that can operate at room temperature and has a low detection limit. Metal oxide semiconductors are excellent gas sensitive materials. Therefore, in this paper, we present the synthesis of fluorine (F) doped zinc oxide (ZnO) porous nanomaterials through a straightforward one-pot method with the optimization of F doping levels to achieve the detection of low concentrations of HCHO under UV light at room temperature.
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