Publications by authors named "Guo Qing Li"

Article Synopsis
  • The GATA transcription factor gene pannier (pnr) is vital for several developmental processes in Drosophila, but its function in coleopteran insects, like the beetle Henosepilachna vigintioctopunctata, has not been thoroughly explored.
  • Researchers identified two splicing variants of the pnr gene in H. vigintioctopunctata and performed analysis at various life stages, finding that RNA interference (RNAi) significantly impacted development, particularly affecting pupal morphometry and female oviposition.
  • Unlike findings in some ladybird species, silencing pnr in this beetle did not alter melanin synthesis, but did result in scutellum formation defects and issues
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  • * Researchers sequenced the genome of C. dianii, finding it has a size of 61.76 Mb and contains over 10,000 predicted coding genes, revealing important genetic information about its pathogenicity.
  • * The study included a comparative analysis with other Calonectria species, shedding light on evolutionary relationships and potential control strategies for managing Eucalyptus leaf blight in the future.
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  • The Colorado potato beetle, a major pest, uses bright colors to signal its toxicity to predators, which comes from toxic compounds that are still being studied.
  • Research reveals that the beetle’s toxic hydrogen cyanide (HCN) is produced from mandelonitrile and other compounds by a gut bacterium called Proteus vulgaris Ld01, which also synthesizes these compounds through genes.
  • Eliminating this bacterium from the beetle reduces HCN emission and makes them more appealing to predators, as shown in experiments where chickens preferred eating bacteria-deprived larvae over others, demonstrating the importance of gut bacteria in the beetle's defense strategy.
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Objective: This study aims to assess the significance of monitoring temperature change trends at various wound sites in the healing process of diabetic foot ulcers after microcirculation reconstruction surgery.

Methods: A retrospective analysis was conducted on individuals with diabetic foot ulcers who had been admitted to the Department of Orthopedics at the Second Hospital of Shanxi Medical University between July 2020 and February 2022. Temperature changes were regularly monitored at the center of the wound and the distal tibia of the ipsilateral lower leg to assess microcirculatory blood perfusion.

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Unlabelled: Carbapenem-resistant (CRPA) is a global threat, but the mechanism of non-carbapenemase carbapenem resistance is still unclear. In the current study, we investigated the contributions of point mutations in , , and to carbapenem resistance in during evolution studies with consecutive clinical isolates. Real-time qPCR and Electrophoretic Mobility Shift Assay demonstrated that MexR (Gln55Pro) mutation increased MexAB efflux pump genes expression by altering MexR's binding capacity, leading to a four- to eight-fold increase in meropenem MIC in the Pae d1 Green ∆ and PAO1∆ mutants.

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In arthropods, the binding of a bursicon (encoded by burs and pburs) heterodimer or homodimer to a leucine-rich repeat-containing G protein coupled receptor LGR2 (encoded by rk) can activate many physiological processes, especially cuticle pigmentation during insect ecdysis. In the current paper, we intended to ascertain whether bursicon signaling mediates body coloration in the 28-spotted larger potato ladybird, Henosepilachna vigintioctomaculata, and if so, by which way bursicon signal governs the pigmentation. The high expression of Hvburs, Hvpburs and Hvrk occurred in the young larvae, pupae and adults, especially in the head and ventral nerve cord.

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To accommodate growth, insects must periodically shed their exoskeletons. In Manduca sexta, Drosophila melanogaster and Tribolium castaneum, Bursicon (Burs)/ Partner of bursicon (Pburs)-LGR2 signal is an indispensable component for the proper execution of ecdysis behavior during adult eclosion. Nevertheless, the behavioral events and the roles of bursicon signaling in other insects deserve further exploration.

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is distributed in several Asian countries. The larvae and adults often cause substantial economic losses to Solanaceae crops such as potato, tomato, eggplant, and Chinese boxthorn. Even though a chromosome-level genome has been documented, the expression profiles of genes involved in development are not determined.

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Article Synopsis
  • Tandem amplification of carbapenemase genes increases their copies, leading to stronger resistance to carbapenem antibiotics, particularly in heterogenous and temporary ways.
  • A specific case was studied involving the amplification of the oxaAb gene in the Acinetobacter baumannii bacteria, which is surrounded by ISAba1 elements, resulting in significant overproduction of the enzyme.
  • The research showed that while the number of gene repeats decreased with the withdrawal of carbapenems, re-exposure to the antibiotic caused a rapid resurgence in the repeat numbers, demonstrating a dynamic response that enhances carbapenem resistance.
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Objective: To explore preemptive analgesic effect of preoperative intramural tramadol injection in percutaneous kyphoplasty (PKP) of vertebrae following local anesthesia.

Methods: From August 2019 to June 2021, 118 patients with thoraco lumbar osteoporotic fractures were treated and divided into observation group and control group, with 59 patients in each gruop. In observation group, there were 26 males and 33 females, aged from 57 to 80 years old with an average of (67.

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  • The C(sp)-N bond is essential in various fields like natural products and pharmaceuticals, prompting the need for efficient formation methods.
  • Recent advancements in photochemical processes combining photoredox and transition-metal catalysis have shown promise as alternatives to traditional methods.
  • This review categorizes new developments in C(sp)-N bond formation based on the transition metals used, focusing on methodology and mechanistic insights to encourage further innovation in this area.
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Background: Osteoarthritis (OA) is the most frequently diagnosed chronic joint disease. CircSEC24A is significantly elevated in OA chondrocytes upon IL-1β stimulation. However, its biological function in OA is still not fully understood.

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  • The strain EcHa1, isolated from dead larvae, shows potential for controlling certain Lepidoptera insects through targeted insecticidal genes.
  • Researchers evaluated 13 housekeeping genes (HKGs) for their stability as reference genes in qRT-PCR, finding that the best combinations varied based on temperature and bacterial OD values.
  • Using the optimal reference genes allowed for the discovery that EcHa1 effectively invades all larval tissues and expresses a key pathogenic factor predominantly in gut, Malpighian tubules, and epidermis, setting the stage for future studies on its functional genes.
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Radical-involved multicomponent difunctionalization of 1,3-dienes has recently emerged as a promising strategy for rapid synthesis of valuable allylic compounds in one-pot operation. However, the expansion of radical scope and enantiocontrol remain two major challenges. Herein, we describe an unprecedented photoinduced copper-catalyzed highly enantioselective three-component radical 1,2-azidooxygenation of 1,3-dienes with readily available azidobenziodazolone reagent and carboxylic acids.

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  • Akirin is a nuclear protein that regulates development in various organisms, but its role in Coleopteran insects has not been studied before the research on Henosepilachna vigintioctopunctata (Hvakirin), a significant potato pest.
  • High levels of akirin transcripts were found during larval, prepupal, and pupal stages, and targeting Hvakirin with RNA interference (RNAi) led to severe developmental issues in larvae, including stunted growth and mortality.
  • The study showed that depletion of Hvakirin inhibited essential processes in gut and fat body remodeling and altered the expression of key genes involved in hormonal signaling, indicating Akirin's vital contribution to the larval development of this beetle.
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  • * A new fluorophosphated SEI that includes fast ion-diffusing inorganic grain boundaries is proposed to improve lithium ion movement within the SEI, addressing the conductivity problem.
  • * The study demonstrates the successful construction of a stable and long-lasting LMB that maintains performance over 1000 cycles at fast-charging rates (5 C) and achieves a high energy density of 400 Wh kg, showcasing the importance of SEI design for better
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During choriogenesis in insects, chorion (eggshell) is formed by surrounding follicular epithelial cells in ovarioles. However, the regulatory endocrine factor(s) activating choriogenesis and the effect of chemical components on eggshell deserve further exploration. In two representative coleopterans, a coccinellid and a chrysomelid , genes encoding the 20-hydroxyecdysone (20E) receptor heterodimer, ecdysone receptor (EcR) and ultraspiracle (USP), and two chitin biosynthesis enzymes UDP-N-acetylglucosamine pyrophosphorylase (UAP) and chitin synthase (ChS1), were highly expressed in ovaries of the young females.

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  • In insects, the initiation of metamorphosis is triggered by a pulse of 20-hydroxyecdysone (20E), which is regulated by both synthesis and degradation processes, where CYP18A1 helps in removing excess 20E.
  • In the study of the potato pest Henosepilachna vigintioctopunctata, high levels of Hvcyp18a1 were identified during larval and late pupal stages, and disrupting its function through RNA interference (RNAi) resulted in stunted growth and developmental issues.
  • The RNAi treatment led to increased levels of a 20E receptor gene and several response transcripts, highlighting CYP18A1's crucial role in regulating pupation and
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The chemokine-like factor (CKLF)-like MARVEL transmembrane domain-containing (CMTM) family includes CMTM1-8 and CKLF, and they play key roles in the hematopoietic, immune, cardiovascular, and male reproductive systems, participating in the physiological functions, cancer, and other diseases associated with these systems. CMTM family members activate and chemoattract immune cells to affect the proliferation and invasion of tumor cells through a similar mechanism, the structural characteristics typical of chemokines and transmembrane 4 superfamily (TM4SF). In this review, we discuss each CMTM family member's chromosomal location, involved signaling pathways, expression patterns, and potential roles, and mechanisms of action in pancreatic, breast, gastric and liver cancers.

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Objectives: Lasiodiplodia pseudotheobromae is an important fungal pathogen associated with die-back, canker and shoot blight in many plant hosts with a wide geographic distribution. The aim of our study was to provide high-quality genome assemblies and sequence annotation resources of L. pseudotheobromae, to facilitate future studies on the systematics, population genetics and genomics of the fungal pathogen L.

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Periprosthetic joint infection (PJI) is a catastrophic complication following joint replacement surgery. One potential treatment approach for PJI could be the combination of one-stage revision and intra-articular infusion of antibiotics. Meropenem is one of the commonly used intra-articular antibiotics in our institution.

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  • A rare subtype of diffuse large B-cell lymphoma (DLBCL), known as IgMs-DLBCL, is characterized by elevated immunoglobulin M (IgM) paraprotein at diagnosis, which usually disappears after treatment.
  • A 59-year-old male patient was diagnosed with stage IA DLBCL and achieved complete remission after treatment, but his IgM levels remained high, prompting further investigation.
  • Detailed analyses revealed simultaneous diagnoses of Waldenström macroglobulinemia (WM) and the MCD subtype of DLBCL, indicating two independent clonal origins for the IgM production in this patient.
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Background: Most cancer patients suffer from the pain of chemotherapy-induced nausea and vomiting (CINV). This meta-analysis was performed to evaluate the efficacy and safety of a regimen consisting of aprepitant, dexamethasone, and 5-HT3 receptor antagonists in the prevention and treatment of CINV.

Methods: A systematic literature search was conducted across multiple databases, including PubMed, EMbase, Cochrane Library, MEDLINE, CENTRAL, HEED, CNKI, Wanfang, and VIP, to identify randomized controlled trials (RCTs) investigating the use of triple therapy (aprepitant, 5-HT3 receptor antagonist, and dexamethasone) to prevent and treat CINV.

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