Assessing the relationships of 1,400 blood metabolites with abdominal aortic aneurysm: a Mendelian randomization study.

Background: Abdominal aortic aneurysm (AAA) is one of the most dangerous types of vascular diseases worldwide. Metabolic disturbance affects disease risk and provide underlying therapeutic targets. Previous studies have reported an association between metabolic disorders and AAA.

CRAT downregulation promotes ovarian cancer progression by facilitating mitochondrial metabolism through decreasing the acetylation of PGC-1α.

Mitochondrial dysfunctions are closely associated with different types of disease, including cancer. Carnitine acetyltransferase (CRAT) is a mitochondrial-localized enzyme catalyzing the reversible transfer of acyl groups from an acyl-CoA thioester to carnitine and regulates the ratio of acyl-CoA/CoA. Our bioinformatics analysis using public database revealed a significant decrease of CRAT expression in ovarian cancer (OC).

Does season regulate heterochronous leaf growth? Mechanisms of petiole-lamina trade-offs in broad-leaved woody plants of the Tianshan Mountains.

As the core of leaf functional traits, the trade-off relationship between the petiole and lamina expresses the plant's adaptability to the environment in terms of support structure and photosynthesis. We investigated the proportions of allometric growth in the relationship between the petiole and the lamina of broadleaf woody plants in temperate highland Tianshan Mountains montane forests through three dimensions (length, area, and mass), including the length of the lamina (LL) and the length of the petiole (PL), and the area of the lamina (LA) and petiole cross sectional area (PCA) versus the mass of the lamina (LM) and the mass of the petiole (PM), as well as exploring the characteristics of the variance in response to seasonal changes. We found that the functional traits in all three dimensions showed a clear convergent evolution as the seasons progressed, that is, a "seasonal effect" of increasing and then decreasing.

Genomic characterization reveals distinct mutational landscape of acral melanoma in East Asian.

Acral melanoma, the most common melanoma subtype in East Asia, is associated with a poor prognosis. This study aims to comprehensively analyze the genomic characteristics of acral melanoma in East Asians. We conduct whole-genome sequencing of 55 acral melanoma tumors and perform data mining with relevant clinical data.

The association between cardiovascular health and obstructive sleep apnea symptoms: findings from NHANES.

Objective: To investigate the association between cardiovascular health (CVH) and obstructive sleep apnea (OSA) within the U.S. population.

Construction and optimization of health behavior prediction model for the older adult in smart older adult care.

Introduction: With the intensification of global aging, health management for the older adult has become a significant societal concern. Addressing challenges such as data diversity, health status complexity, long-term dependence, and data privacy is crucial for predicting older adult health behaviors.

Methods: This study designs and implements a smart older adult care service model incorporating modules like multimodal data fusion, data loss processing, nonlinear prediction, emergency detection, and privacy protection.

The discharge of chlorinated effluent from wastewater treatment plants enhances dissolved oxygen in the receiving river: From laboratory study to practical application.

Dissolved oxygen (DO) is essential for the health of aquatic ecosystems, supporting biogeochemical cycles and the decomposition of organic matter. However, continuous untreated external inputs from illicit discharges or sewer overflows, coupled with inadequate ecological base flow, have led to widespread river deoxygenation and serious ecological crises. This study demonstrates that chlorinated wastewater treatment plant (WWTP) effluent can significantly enhance DO levels in downstream rivers, particularly in areas with high pollution loads or poor ecological base flow.

Perception of recurrence risk in patients with IgG4-related disease: a descriptive phenomenological study.

Objective: About 40% of IgG4-related disease (IgG4-RD) patients face recurrence, severely impacting their quality of life. We aimed to explore the characteristics of the perception of recurrence risk in patients with IgG4-RD.

Methods: A qualitative study design with a descriptive phenomenological approach was used.

Characterizing ADRs of Enfortumab vedotin and Erdafitinib in bladder cancer treatment: a descriptive analysis from WHO-VigiAccess.

Introduction: Enfortumab vedotin (EV) and Erdafitinib are effective therapeutic drugs for bladder cancer patients following post-chemotherapy and immunotherapy. This study assessed adverse drug reactions (ADRs) from both drugs, comparing their safety profiles to guide clinical use.

Methods: A retrospective descriptive analysis was conducted on ADR reports for EV and Erdafitinib from the World Health Organization (WHO)-VigiAccess database.

Corrigendum: SERPIND1 affects the malignant biological behavior of epithelial ovarian cancer via the PI3K/AKT pathway: a mechanistic study.

[This corrects the article DOI: 10.3389/fonc.2019.

[Successful treatment of rheumatoid arthritis complicated with myasthenia gravis with low-dose rituximab: A case report].

Rheumatoid arthritis (RA) and myasthenia gravis (MG) are two distinct autoimmune diseases. Compared with the general population, the incidence of RA is notably higher among patients with MG. Similarly, the rate of MG in patients diagnosed with RA is also significantly increased.

Conformation pattern changes in R1-pS262 tau peptide induced endogenous tau aggregation, synaptic damage, and cognitive impairments.

Background: To date, the effect of tau phosphorylation at different amino acid sites on the conformation and function of tau is still unclear in Alzheimer's disease (AD). Protein fingerprinting, also known as the protein folding shape code (PFSC) method, is a protein structure prediction technique based on protein sequence, which can reveal proteins' most likely spatial conformation.

Objective: To investigate the effect of phosphorylation on tau protein conformation using PFSC technology and further analyze the differences in the effect of phosphorylation on tau aggregation at specific sites.

Effects of problem-based learning on EFL learning: A systematic review.

Teaching English as a foreign language (EFL) is a priority globally, but pedagogical methods do not always keep up with the evolving needs of learners. Problem-based learning (PBL) is an innovative pedagogical approach that facilitates students' self-regulated learning, thereby improving their English proficiency. The present systematic literature review therefore concentrates on the application of PBL methodology in improving students' English language proficiency.

Predictive performance of a centrosome-associated prognostic model in prognosis and immunotherapy of lung adenocarcinoma.

In recent years, mounting investigations have highlighted the pivotal role of centrosomes in cancer progression. In this study, we employed bioinformatics and statistics to establish a 13-centrosome-associated gene prognostic model for lung adenocarcinoma (LUAD) utilizing transcriptomic data from TCGA. Based on the Riskscore, patients were stratified into high- and low-risk groups.

Uncovering the pharmacological mechanism and the main herbal medicine contributing to the efficacy of Xiaoyanlidan Tablet (XYLDT) in treating cholestatic liver injury.

Ethnopharmacological Relevance: Xiaoyanlidan Tablet (XYLDT) is a Chinese patent medicine consisted of three traditional Chinese medicines (TCMs) including Andrographis Herba (AH), Linearstripe Rabdosia Herba (LRH) and Picrasmae Ramulus et Folium (PRF). In Chinese traditional medicine theory, XYLDT has the "heat-clearing, dampness-dispelling and gallbladder function promoting" properties, and was widely used in the clinic for decades to treat pain in the subcostal region or bitter taste in the mouth, which were induced by liver-gallbladder dampness-heat. Meanwhile, it was also used for the therapy of acute cholecystitis and cholangitis.

Hub genes, diagnostic model, and predicted drugs related to ferroptosis in chronic rhinosinusitis with nasal polyps.

Significant progress has been made in the pathogenesis of chronic rhinosinusitis (CRS). However, the relationship between chronic rhinosinusitis with nasal polyps (CRSwNP) and ferroptosis, as well as its underlying molecular mechanism, remains unclear. This study aimed to investigate the correlation between CRSwNP and ferroptosis and identify key gene associated with ferroptosis that could impact the diagnosis and treatment of CRS.

TREM2 bridges microglia and extracellular microenvironment: Mechanistic landscape and therapeutical prospects on Alzheimer's disease.

Neuroinflammation is closely related to the pathogenesis of Alzheimer's disease (AD). One of its prominent cellular components, microglia, is a potent coordinator of neuroinflammation in interplay with the characteristic AD pathological alterations including Aβ, tau, and neuronal defects, which constitute the AD-unique extracellular microenvironment. Mounting evidence implicates Triggering Receptors Expressed on Myeloid Cells 2 (TREM2) in the center of microglial activation, a vital event in the pathogenesis of AD.

Association between different GLP-1 receptor agonists and acute pancreatitis: case series and real-world pharmacovigilance analysis.

Objective: Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have shown notable advancements in managing blood sugar control. Nevertheless, there remains a gap in real-world data regarding the variation in acute pancreatitis (AP) risk among different GLP-1 RAs. Our study aimed to characterize and evaluate AP associated with different GLP-1 RAs (exenatide, lixisenatide, liraglutide, albiglutide, semaglutide, dulaglutide and tirzepatide) in a public adverse events database and to review the relevant case reports.

Triglyceride glucose index: a significant prognostic marker of heart failure in patients with chronic kidney disease.

Background: Triglycerides and glucose (TyG) index, a relatively convenient method for assessing insulin resistance, has been confirmed as an independent predictor both for chronic kidney disease (CKD) and cardiovascular disease (CVD) in previous studies. However, a few studies focus on the prognostic value of TyG index for CVD in patients diagnosed with CKD, especially in advanced CKD patients. In this study, we aim to investigate the prognostic value of TyG index for heart failure (HF) in patients with non-dialysis CKD stage 3-5.

Effect of inoculated sludge concentration on start-up of anammox reactor: Nitrogen removal performance and metabolic pathways.

The anammox process is efficient for nitrogen removal but faces challenges due to slow bacterial growth and limited inoculated sludge supply. This study examined the effects of different inoculated sludge concentrations (3.5, 7, and 14 g/L) on start-up and nitrogen metabolism in anammox reactors.

Evolutionary game analysis of building a sustainable intelligent elderly care service platform.

With the rapid aging of populations and advancements in information technology, the development of intelligent elder-care service platforms (IESPs) has gained momentum. This paper examines the feasibility and strategies for constructing an IESP. Unlike commercial internet platforms, IESP facilitates transactions in elderly care services, which are quasi-public goods requiring government guidance and multi-stakeholder collaboration.

Upper Extremity Pseudoparalysis: A Case Report of Bilateral Nursemaid's Elbows.

Radial head subluxation (RHS), commonly known as 'nursemaid's elbow,' typically presents in pediatric patients with acute-onset unilateral arm pain and pseudoparalysis. The classic mechanism of injury involves a longitudinal traction force pulling the radial head through the annular ligament. Bilateral RHS is exceedingly rare, with only a few cases documented in the literature; notably, all cases with a provided history and physical exam presented with the classic mechanism of injury, aiding in diagnosis and treatment.