Trimethylamine N-oxide induces cardiac diastolic dysfunction by down-regulating Piezo1 in mice with heart failure with preserved ejection fraction.

Aims: The present study aimed to investigate the direct link between trimethylamine N-oxide (TMAO) and diastolic dysfunction in heart failure with preserved ejection fraction (HFpEF).

Materials And Methods: Diastolic dysfunction is the main manifestation of HFpEF, so the "two-hit" mouse HFpEF model are used. After treated with high-fat diet (HFD) and N-nitro-l-arginine methyl ester (L-NAME) for 8 weeks, the cardiac function, myocardial fibrosis, oxidative stress levels, and molecular alterations were assessed.

Design of low-carbon planning model for vehicle path based on adaptive multi-strategy ant colony optimization algorithm.

In contemporary transportation systems, the imperatives of route planning and optimization have become increasingly critical due to vehicles' burgeoning number and complexity. This includes various vehicle types, such as electric and autonomous vehicles, each with specific needs. Additionally, varying speeds and operational requirements further complicate the process, demanding more sophisticated planning solutions.

Extreme pH Tolerance in Peptide Coacervates Mediated by Multivalent Hydrogen Bonds for Enzyme-Triggered Oral Drug Delivery.

Biopolymer-based complex coacervates hold promising prospects in the field of biomedicine. However, their low stability in environments with extreme pH and high salt concentrations, largely due to weakly charged biomacromolecules and insufficient understanding of their assembly processes, has hindered their practical applications in oral drug delivery. Here, we have developed Dopa-containing peptide-based complex coacervates that are stable across a wide range of pH (1-11) and salt concentrations.

The Value of Fecal Calprotectin Combined with Procalcitonin in the Differential Diagnosis of Bacterial and Viral Diarrhea in Children.

Infectious diarrhea frequently occurs in children, and accurate diagnosis is essential for providing prompt treatment. Fecal calprotectin (FC) and procalcitonin (PCT) are useful in differentiating types of infectious diarrhea. Therefore, this study aims to assess the value of combining FC and PCT in the differential diagnosis of bacterial and viral diarrhea in children.

Spatial distribution characteristics and influencing factors of China martial arts schools based on Baidu map API.

This paper examines the spatial distribution pattern and influencing factors of Martial Arts Schools (MASs) based on Baidu map data and Geographic Information System (GIS) in China. Using python to obtain the latitude and longitude data of the MASs through Baidu Map API, and with the help of ArcGIS (10.7) to coordinate information presented on the map of China.

Bidirectional association between ADL disability and depressive symptoms among older adults: longitudinal evidence from CHARLS.

This study investigates the bidirectional relationship between Activities of Daily Living (ADL) disability and depressive symptoms (DS) among middle-aged and older adults in China, utilizing data from the China Health and Retirement Longitudinal Study (CHARLS) from 2015 to 2018. A total of 8994 participants were analyzed to assess the impact of ADL on the risk of depressive symptoms, while 9673 participants were included to examine the influence of depressive symptoms on the risk of ADL disability. Cox proportional hazards regression models were employed to evaluate these relationships, adjusting for sociodemographic, lifestyle, and health-related covariates.

Fine mapping of stripe rust resistance gene YrAn1589 in common wheat using Wheat660K SNP array and BSR-Seq.

A new stripe rust resistance gene YrAn1589 in Chinese wheat Annong1589 was mapped to a 160.9-166.6 kb interval on chromosome arm 3BL and co-segregated with a marker CAPS9 developed from candidate gene TraesCS3B03G1054600.

Durable Acidic Oxygen Evolution Via Self-Construction of Iridium Oxide/Iridium-Tantalum Oxide Bi-Layer Nanostructure with Dynamic Replenishment of Active Sites.

Proton exchange membrane (PEM) water electrolysis presents considerable advantages in green hydrogen production. Nevertheless, oxygen evolution reaction (OER) catalysts in PEM water electrolysis currently encounter several pressing challenges, including high noble metal loading, low mass activity, and inadequate durability, which impede their practical application and commercialization. Here we report a self-constructed layered catalyst for acidic OER by directly using an Ir-Ta-based metallic glass as the matrix, featuring a nanoporous IrO surface formed in situ on the amorphous IrTaO nanostructure during OER.

Hypoxia-inducible factor 1α inhibitor reduces hippocampal neuronal ferroptosis.

Epilepsy is a prevalent neurological disorder in which hippocampal neuronal damage, particularly ferroptosis, plays a critical role. Previous studies have shown that hypoxia-inducible factor 1α is considered an important regulator of cellular stress responses and has been confirmed to play a critical role in the occurrence of various diseases. However, the mechanisms by which hypoxia-inducible factor 1α is related to epilepsy and neuronal ferroptosis remain unclear.

scBSP: A fast and accurate tool for identifying spatially variable features from high-resolution spatial omics data.

Emerging spatial omics technologies empower comprehensive exploration of biological systems from multi-omics perspectives in their native tissue location in two and three-dimensional space. However, sparse sequencing capacity and growing spatial resolution in spatial omics present significant computational challenges in identifying biologically meaningful molecules that exhibit variable spatial distributions across different omics. We introduce scBSP, an open-source, versatile, and user-friendly package for identifying spatially variable features in high-resolution spatial omics data.

Simultaneous profiling of native-state proteomes and transcriptomes of neural cell types using proximity labeling.

Deep molecular phenotyping of cells at transcriptomic and proteomic levels is an essential first step to understanding cellular contributions to development, aging, injury, and disease. Since proteome and transcriptome level abundances only modestly correlate with each other, complementary profiling of both is needed. We report a novel method called simultaneous protein and RNA -omics (SPARO) to capture the cell type-specific transcriptome and proteome simultaneously from both in vitro and in vivo experimental model systems.

Relationship between accelerometer-measured physical activity and depressive symptoms in hemodialysis patients with comorbid diabetes mellitus: a multicenter cross-sectional study.

Objective: The objective of this study was to examine the association between accelerometer-derived moderate-to-vigorous physical activity (MVPA) and depressive symptoms in hemodialysis patients with and without type 2 diabetes mellitus (T2DM).

Methods: This cross-sectional study finally included 450 maintenance hemodialysis patients (male 281, average age 62 years) from seven dialysis centers in Shanghai, China. Physical activity (PA) was measured using the triaxial accelerometer (ActiGraph GT3X+, Pensacola, FL, United States).

Supplemented with Astragalus dregs improves growth performance, immunity, and antioxidant capacity in fattening pigs.

This study aimed to investigate the impact of Astragalus dregs - the residue after the extraction of principal active components - on the growth performance, antioxidant capacity, and immune function of fattening pigs. Twenty-four 130 days of age fattening pigs were randomly assigned to the control group and experimental group (supplemented with 10% Astragalus dregs). The production performance was evaluated by average daily gain (ADG), average daily feed intake (ADFI) and diarrhoea rates.

Longevity Humans Have Youthful Erythrocyte Function and Metabolic Signatures.

Longevity individuals have lower susceptibility to chronic hypoxia, inflammation, oxidative stress, and aging-related diseases. It has long been speculated that "rejuvenation molecules" exist in their blood to promote extended lifespan. We unexpectedly discovered that longevity individuals exhibit erythrocyte oxygen release function similar to young individuals, whereas most elderly show reduced oxygen release capacity.

Association between cadherin-related family member 3 rs6967330-A and human rhinovirus-C induced wheezing in children.

Background: The heterogeneity of childhood wheezing illnesses is associated with viral and host factors. Human rhinoviruses (HRV) are the major pathogens in severe wheezing in young children. The single nucleotide polymorphism (SNP) rs6967330 G > A proved to heighten the risk of wheezing.

Development of a set of monosomic alien addition lines from Gossypium raimondii in Gossypium hirsutum toward breeding applications in cotton.

Background: Gossypium raimondii Ulbr is a diploid wild cotton (2n = 26, DD) that originated in west-central Peru of South America and possesses desirable characteristics that are absent in the Upland cotton G. hirsutum. Many beneficial genes were lost from G.

Hydrogen sulfide attenuates sepsis-induced cardiac dysfunction in infant rats by inhibiting the expression of cold-inducible RNA-binding protein.

Sepsis-induced cardiac dysfunction is one of the most common complications of sepsis. It is also a major cause of death in pediatric intensive care units. The underlying mechanism of sepsis-induced cardiac dysfunction remains elusive.

Proximity labeling of the Tau repeat domain enriches RNA-binding proteins that are altered in Alzheimer's disease and related tauopathies.

In Alzheimer's disease (AD) and other tauopathies, tau dissociates from microtubules and forms toxic aggregates that contribute to neurodegeneration. Although some of the pathological interactions of tau have been identified from postmortem brain tissue, these studies are limited by their inability to capture transient interactions. To investigate the interactome of aggregate-prone fragments of tau, we applied an proximity labeling technique using split TurboID biotin ligase (sTurbo) fused with the tau microtubule repeat domain (TauRD), a core region implicated in tau aggregation.

Hydrogel inspired by "adobe" with antibacterial and antioxidant properties for diabetic wound healing.

With the aging population, the incidence of diabetes is increasing. Diabetes often leads to restricted neovascularization, antibiotic-resistant bacterial infections, reduced wound perfusion, and elevated reactive oxygen species, resulting in impaired microenvironments and prolonged wound healing. Hydrogels are important tissue engineering materials for wound healing, known for their high water content and good biocompatibility.

Raptin, a sleep-induced hypothalamic hormone, suppresses appetite and obesity.

Sleep deficiency is associated with obesity, but the mechanisms underlying this connection remain unclear. Here, we identify a sleep-inducible hypothalamic protein hormone in humans and mice that suppresses obesity. This hormone is cleaved from reticulocalbin-2 (RCN2), and we name it Raptin.

Depression as a risk factor for osteoporosis independent of sarcopenia in hemodialysis patients: findings from a multicenter cross-sectional study.

Background: Osteoporosis and sarcopenia frequently occur in patients with end-stage renal disease undergoing hemodialysis (HD), and depression is also a common mental health issue in this population. Despite the prevalence of these conditions, the interrelationships among them remain poorly understood in HD patients.

Methods: In this multicenter cross-sectional study, 858 HD patients from 7 dialysis centers were recruited.

High serum CA19-9 predicts severe cholecystitis in calculous cholecystitis patients.

Background: CA19-9 is a classical tumor marker and plays an important role in the diagnosis of biliary and pancreatic cancer. However, a few cases reported that the tumor maker CA19-9 is abnormally elevated in patients with calculous cholecystitis, but the relation between severity of calculous cholecystitis and serum CA19-9 level are still unknown.

Methods: Total 105 calculous cholecystitis patients from first hospital were collected and divided into high serum CA19-9 group(high group, n = 35) and normal serum CA19-9 group(normal group, n = 70).

A Phosphate-Starvation Enhanced Purple Acid Phosphatase, GmPAP23 Mediates Intracellular Phosphorus Recycling and Yield in Soybean.

Plant internal phosphorus (P) recycling is a complex process, which is vital for improving plant P use efficiency. However, the mechanisms underlying phosphate (Pi) release from internal organic-P form remains to be deciphered in crops. Here, we functionally characterised a Pi-starvation responsive purple acid phosphatase (PAP), GmPAP23 in soybean (Glycine max).

The effect of instability resistance training on balance ability among athletes: a systematic review.

Background: Instability resistance training (IRT) has been the focus of extensive research because of its proven benefits to balance ability, core stability, and sports performance for athletes. However, there is a lack of systematic reviews explicitly evaluating IRT's impact on athletes' balance ability. This study aims to conduct a systematic review of the effects of IRT on balance ability among athletes.

Antimicrobial proteins from oyster hemolymph improve the efficacy of conventional antibiotics.

Discovering new antibiotics and increasing the efficacy of existing antibiotics are priorities to address antimicrobial resistance. Antimicrobial proteins and peptides (AMPPs) are considered among the most promising antibiotic alternatives and complementary therapies. Here, we build upon previous work investigating the antibacterial activity of a semi-purified hemolymph protein extract (HPE) of the Australian oyster Saccostrea glomerata.