[Effects of NaCl stress on polyamine contents in grafted cucumber leaves].

With a Japanese salt-tolerant pumpkin cultivar 'King Shintosa' (Cucurbita maxima x C. moschata) as rootstock and a cucumber (Cucumis sativus) cultivar 'Xintaimici' as cion, this paper studied the temporal dynamics of different form polyamines contents in the leaves of grafted and own-rooted cucumber plants under 100 mmol x L(-1) NaCl stress. The results showed that the free putrescence (Put) content of graftedplant leaves (G2) was significantly higher than that of own-rooted plant leaves (O2), except on the second day of NaCl stress.

[Effects of NaCl stress on the growth, antioxidant enzyme activities and reactive oxygen metabolism of grafted eggplant].

By the method of hydroponics and with the salt-tolerant eggplant cultivar 'Torvum Vigor' (Solanum torvum) from Japan as rootstock and the cultivar 'Suqiqie' (Solanum melongena L. ) as scion, this paper studied the differences between grafted and own-root seedlings in their photosynthetic characteristics, antioxidant enzyme activities, and reactive oxygen metabolism under 80 mmol x L(-1) NaCl stress. The results showed that under NaCl stress, the dry mass, chlorophyll content and photosynthetic rate of grafted seedlings were 67.

Novel 3-oxa lipoxin A4 analogues with enhanced chemical and metabolic stability have anti-inflammatory activity in vivo.

Lipoxin A(4) (LXA(4)) is a structurally and functionally distinct natural product called an eicosanoid, which displays immunomodulatory and anti-inflammatory activity but is rapidly metabolized to inactive catabolites in vivo. A previously described analogue of LXA(4), methyl (5R,6R,7E,9E,11Z,13E,15S)-16-(4-fluorophenoxy)-5,6,15-trihydroxy-7,9,11,13-hexadecatetraenoate (2, ATLa), was shown to have a poor pharmacokinetic profile after both oral and intravenous administration, as well as sensitivity to acid and light. The chemical stability of the corresponding E,E,E-trien-11-yne analogue, 3, was improved over 2 without loss of efficacy in the mouse air pouch model of inflammation.

Structure function differences in nonpeptide CCR1 antagonists for human and mouse CCR1.

A useful strategy for identifying ligand binding domains of G protein-coupled receptors has been the exploitation of species differences in antagonist potencies. We have used this approach for the CCR1 chemokine receptor with a novel series of antagonists, the 4-hydroxypiperidines, which were discovered by high throughput screening of human CCR1 and subsequently optimized. The structure-activity relationships for a number of different 4-hydroxypiperidine antagonists for human and mouse CCR1 were examined by receptor binding and functional assays.