Improving stability and bioavailability of ACNs based on Gellan gum-whey protein isolate nanocomplexes.

Blueberry anthocyanins (ACNs) have been widely applied in the food industry and medicine due to their numerous beneficial properties. However, the stability of ACNs is extremely poor. This study aimed to develop a delivery system for ACNs using nanocomplexes prepared from gellan gum (GG) and whey protein isolate (WPI) via Maillard reaction.

Prognostic Value of Systemic Inflammatory Markers in Elderly Patients with Tumor-associated Venous Thromboembolism.

Background: Elderly tumor patients are more prone to venous thrombotic events than nontumor patients. To investigate the relationship between systemic inflammatory markers and overall survival (OS) in elderly patients with tumorassociated venous thromboembolism (TAVTE). And to evaluate the prognostic value of combined lymphocyte platelettolymphocyte ratio (PLR) with neoplasm metastasis in elderly patients.

Activatable Sulfur Dioxide Nanosonosensitizer Enables Precisely Controllable Sono-Gaseous Checkpoint Trimodal Therapy for Orthotopic Hepatocellular Carcinoma.

Immune checkpoint blockade (ICB) is combined with sonodynamic therapy (SDT) to increase response rates and enhance anticancer efficacy. However, the "always on" property of most sonosensitizers in reducing tumor microenvironment (TME) compromises the therapeutic outcome of sonoimmunotherapy and exacerbates adverse side effects. Precisely controllable strategies combining sulfur dioxide (SO) gas therapy with cancer immunotherapy can address these issues but remain lacking.

IRGM Deficiency Exacerbates Sepsis-Induced Acute Lung Injury by Inhibiting Autophagy Through the AKT/mTOR Signaling Pathway.

Background: Sepsis is a life-threatening condition characterized by organ dysfunction due to an impaired immune response to infection. The lungs are highly susceptible to infection, often resulting in acute lung injury (ALI). The immune-related GTPase M (IRGM) and its murine homolog Irgm1 mediate autophagy and are implicated in inflammatory diseases, yet their roles in sepsis-induced ALI remain unclear.

Physical and mental health status and influencing factors of older adults in community-dwelling in Northeast China: a cross-sectional study.

Background: Between 2020 and 2022, the COVID-19 pandemic spread globally, and the implementation of preventive measures led to reduced outdoor activities for older adults, resulting in a decline in social functioning. This study aims to improve community-based health interventions tailored to older adults experiencing physical and psychological declines following the COVID-19 pandemic.

Methods: This study utilized previous data mining results to estimate the demand for community health services for older adults.

Promising nanotherapeutics of stem cell extracellular vesicles in liver regeneration.

Extracellular vesicles (EVs) have gainedsignificant attention due totheir crucialroles invarious biological systems. This review aims to explore the functions of EVs in both in physiological and pathological states of the liver, with a specific focus on the potential mechanisms and concrete evidence of EVs in liver regeneration processes. The review begins by emphasizing the importance of EVs in maintaining liver health and their involvement in different pathological conditions, starting from the liver's own EVs.

Achieving Ultra-High Heat Flux Transfer in Graphene Films via Tunable Gas Escape Channels.

Graphene films have been applied in the thermal management of electronic devices due to their high thermal conductivity. However, the ever-increasing power and local heat flux density of electronic chips require graphene films with excellent heat flux carrying capacity. Enhancing the heat flux carrying capacity is highly challenging, and the key is to maintain high thermal conductivity while increasing film thickness.

F-FDG PET/CT for predicting inferior vena cava wall invasion in patients of renal cell carcinoma with the presence of inferior vena cava tumor thrombus.

Introduction: Preoperative evaluation of inferior vena cava (IVC) wall invasion is very important to improve outcomes of patients with renal cell carcinoma (RCC), and may allow surgical urologists to treat the IVC more effectively. The objective of this study was to evaluate preoperative F-FDG PET/CT in patients with RCC and IVC tumor thrombus (IVCTT) for the diagnosis of IVC wall invasion.

Methods: This retrospective case-control study evaluated 68 patients with RCC with level I-IV tumor thrombus.

Chitinase and Deacetylase-Based Chitin-Degrading Bacteria: One-Pot Cascade Bioconversion of Chitin to Chitooligosaccharides.

Cascade conversion of chitin into soluble and functional chitooligosaccharides has gained great attention. However, the biotransformation route is still limited to the low catalytic performances of chitin deacetylases (CDAs) and complicated procedures. In this study, a CDA from sp.

VAE-WACGAN: An Improved Data Augmentation Method Based on VAEGAN for Intrusion Detection.

To address the class imbalance issue in network intrusion detection, which degrades performance of intrusion detection models, this paper proposes a novel generative model called VAE-WACGAN to generate minority class samples and balance the dataset. This model extends the Variational Autoencoder Generative Adversarial Network (VAEGAN) by integrating key features from the Auxiliary Classifier Generative Adversarial Network (ACGAN) and the Wasserstein Generative Adversarial Network with Gradient Penalty (WGAN-GP). These enhancements significantly improve both the quality of generated samples and the stability of the training process.

Assessment of iron metabolism and iron deficiency in incident patients on incident continuous ambulatory peritoneal dialysis.

Objective: The aim of this study was to investigate iron status and iron deficiency in incident continuous ambulatory peritoneal dialysis (CAPD) patients and identify influencing factors.

Methods: Patients with end-stage renal disease were enrolled. Clinical data of iron metabolism and biochemical and dialysis parameters during the first peritoneal dialysis evaluation were collected.

Positive effects of molybdenum on the biomineralization process on the surface of low-alloy steel catalyzed by .

The adhesion of microorganisms and the subsequent formation of mineralized layers in biofilms are of great significance in inhibiting the corrosion of metal materials. In this work, we found that the adhesion and subsequent mineralization of on the surface of low-alloy steel are influenced by the molybdenum in the material. The addition of molybdenum will lead to increased adhesion of on the material surface, and the subsequent biomineralization ability has also been improved.

Impact of positive CD4 cells on event-free survival in follicular lymphoma patients.

Objective: Previous results about prognostic value of CD4+ T cells in follicular lymphoma (FL) remain controversial.

Methods: Immunohistochemistry was used to examine expression of positive CD4 cells in 103 patients with FL 1-3A. Early failure was described as failing to achieve event-free survival (EFS) at 12 or 24 months.

Integrating amino acids into Bcr-Abl inhibitors: design, synthesis, biological evaluation, and studies.

Bcr-Abl is successfully applied to drug discovery as a CML therapeutic target, but point mutation resistance has become a major challenge in the clinical treatment of CML. Our previous studies have shown that the introduction of amino acids as flexible linkers and heterocyclic structures as HBMs can achieve potent inhibition of Bcr-Abl. In continuation of these studies, we further enriched the linker types by developing a library of compounds with -leucine or serine as a linker.

Potential-driven structural distortion in cobalt phthalocyanine for electrocatalytic CO/CO reduction towards methanol.

Cobalt phthalocyanine immobilized on carbon nanotube has demonstrated appreciable selectivity and activity for methanol synthesis in electrocatalytic CO/CO reduction. However, discrepancies in methanol production selectivity and activity between CO and CO reduction have been observed, leading to inconclusive mechanisms for methanol production in this system. Here, we discover that the interaction between cobalt phthalocyanine molecules and defects on carbon nanotube substrate plays a key role in methanol production during CO/CO electroreduction.

Construction of an amylolytic strain with high copies of α-amylase and glucoamylase genes integration for bioethanol production from sweet potato residue.

Sweet potato residue (SPR) is the by-product of starch extraction from fresh sweet potatoes and is rich in carbohydrates, making it a suitable substrate for bioethanol production. An amylolytic industrial yeast strain with co-expressing α-amylase and glucoamylase genes would combine enzyme production, SPR hydrolysis, and glucose fermentation into a one-step process. This consolidated bioprocessing (CBP) shows great application potential in the economic production of bioethanol.

Recryopreservation impairs blastocyst implantation potential via activated endoplasmic reticulum stress pathway and induced apoptosis.

Recryopreservation (recryo) is occasionally applied in clinical, while the underlying mechanism of impaired clinical outcomes after recryo remains unclear. In this study, frozen embryo transfer (FET) cycles of single blastocyst transfer in an academic reproductive medicine center were enrolled. According to the number of times blastocysts experienced cryopreservation, they were divided into the cryopreservation (Cryo) group and the Recryo group.