Discovery of novel paeonol-based derivatives against skin inflammation and .

T-LAK-cell-originated protein kinase (TOPK), a novel member of the mitogen-activated protein kinase family, is considered an effective therapeutic target for skin inflammation. In this study, a series () of paeonol derivatives was designed and synthesised using a fragment growing approach, and their anti-inflammatory activities against lipopolysaccharide (LPS)-induced nitric oxide production in RAW264.7 cells were tested.

[Distribution Characteristics and Health Risk Assessment of Thirteen Sulfonamides Antibiotics in a Drinking Water Source in East China].

Trace levels of residual antibiotics in drinking water sources may threaten public health and becomes a serious issue in modern society. Occurrence and distribution of 13 sulfonamides antibiotics in a drinking water source in East China were investigated using solid phase extraction-high performance liquid chromatography-tandem mass spectrometry. The results revealed that all 13 sulfonamides were detected with the total concentrations ranging from 10.

Regeneration and reuse of iron catalyst for Fenton-like reactions.

Fenton and Fenton-like reactions employed for oxidative treatment of a typical industrial wastewater generate a large amount of ferric hydroxide sludge which has to be properly disposed at a high cost. This paper presents a simple and cost-effective method for recovering the iron catalyst from the iron hydroxide sludge for oxidative treatment of industrial wastewaters. The sludge was dewatered, dried and baked at 350-400 degrees C for 20-30 min; the residual solids were dissolved in sulfuric acid to form the reusable catalyst for Fenton and Fenton-like reactions.