[The inversion of nitrogen balance index in typical growth period of soybean based on high definition digital image and hyperspectral data on unmanned aerial vehicles].

Nitrogen balance index (NBI) is one of the important indicators for crop growth. The high and low status of nitrogen can be quickly monitored by measuring NBI, which can provide accurate information of agricultural production and management. The relationship between NBI and original spectrum and derivative spectrum of infrared and near infrared wavelength from flowering to maturity stage was analyzed based on high definition digital image and hyperspectral data on unmanned aerial vehicles.

Accurate global potential energy surface for the ground state of CH by extrapolation to the complete basis set limit.

A full three-dimensional global potential energy surface is reported for the ground state of CH by fitting accurate multireference configuration interaction energies calculated using aug-cc-pVQZ and aug-cc-pV5Z basis sets with extrapolation of the electron correlation energy to the complete basis set limit. The topographical characteristics have been compared in detail with a potential energy surface of the same type recently reported [, 2015, , 124302] based on a least-squares fit to accurate high level MRCI(Q) energies, calculated using AV6Z basis set. The new three-dimensional global potential energy surface is then used in quasiclassical trajectory calculations for H(S) + CH( Σ) → C(P) + H( Σ ) reaction.

Crystal structure of the Kelch domain of human NS1-binding protein at 1.98 Å resolution.

NS1-binding protein (NS1-BP), which belongs to the Kelch protein superfamily, was first identified as a novel human 70 kDa protein that interacts with NS1 of Influenza A virus. It is involved in many cell functions, including pre-mRNA splicing, the ERK signalling pathway, the aryl hydrocarbon receptor (AHR) pathway, F-actin organization and protein ubiquitylation. However, the structure of NS1-BP is still unknown, which may impede functional studies.

Silencing of LncRNA-HOTAIR decreases drug resistance of Non-Small Cell Lung Cancer cells by inactivating autophagy via suppressing the phosphorylation of ULK1.

Drug resistance is an important factor leading to the recurrence and metastasis of Non-Small Cell Lung Cancer (NSCLC). Long non-coding RNAs (LncRNAs) play important roles in drug resistance of tumor cells. The aim of our study was to investigate the mechanism of LncRNA-HOTAIR in regulating drug resistance of NSCLC cells.

A fuzzy feature fusion method for auto-segmentation of gliomas with multi-modality diffusion and perfusion magnetic resonance images in radiotherapy.

The diffusion and perfusion magnetic resonance (MR) images can provide functional information about tumour and enable more sensitive detection of the tumour extent. We aimed to develop a fuzzy feature fusion method for auto-segmentation of gliomas in radiotherapy planning using multi-parametric functional MR images including apparent diffusion coefficient (ADC), fractional anisotropy (FA) and relative cerebral blood volume (rCBV). For each functional modality, one histogram-based fuzzy model was created to transform image volume into a fuzzy feature space.

Optimization of Graphene Conductive Ink with 73 wt% Graphene Contents.

With the pace of development accelerating in printed electronics, the fabrication and application of conductive ink have been brought into sharp focus in recent years. The discovery of graphene also unfolded a vigorous research campaign. In this paper, we prepared graphene conductive ink and explored the feasibility of applying the ink to flexible paper-based circuit.

Mapping and validation of a new QTL for adult-plant resistance to powdery mildew in Chinese elite bread wheat line Zhou8425B.

Four QTLs for adult-plant resistance to powdery mildew were mapped in the Zhou8425B/Chinese Spring population, and a new QTL on chromosome 3B was validated in 103 wheat cultivars derived from Zhou8425B. Zhou8425B is an elite wheat (Triticum aestivum L.) line widely used as a parent in Chinese wheat breeding programs.

Inhibitory effect of Patrinia on BRL-3A cell apoptosis through the TLR4/PI3K/AKT/GSK3β and TLR4/P38/JNK signaling pathways.

The present study investigated the inhibitory effect of Patrinia on lipopolysaccharide (LPS)-induced apoptosis of rat liver BRL‑3A cells. A Cell Counting Kit‑8 assay was performed to measure the effect of Patrinia on BLR‑3A cell activities. A biochemical assay was employed to detect the release of lactate dehydrogenase (LDH) in BRL‑3A cells induced by different doses of LPS.

MicroRNA-494 promotes cancer progression and targets adenomatous polyposis coli in colorectal cancer.

Background: Aberrant activation of the Wnt/β-catenin signaling pathway is frequently observed in colorectal cancer (CRC). β-catenin is the major Wnt signaling pathway effector and inactivation of adenomatous polyposis coli (APC) results in nuclear accumulation of β-catenin. It has been suggested that inactivation of APC plays an important role in activation of the Wnt/β-catenin pathway and in the progression of colorectal tumorigenesis.

Research progress on 5hmC and TET dioxygenases in neurodevelopment and neurological diseases.

The development of the nervous system is coordinately regulated by multiple interacting factors. If a certain factor is altered or mutated, the coordinated developmental processes could be disrupted, resulting in neurological diseases. The 5-hydroxymethylcytosine (5hmC) is an intermediate product of the DNA demethylation processes.

Mitochondrially produced ATP affects stem cell pluripotency via Actl6a-mediated histone acetylation.

ATP is mainly generated by glycolysis in pluripotent stem cells (PSCs) and is consumed to maintain cell viability. Differences in mitochondrial activity among induced (i)PSCs with different degrees of pluripotency are poorly understood. In this study, by comparing gene expression and mitochondrial activity among iPSCs with different degrees of pluripotency, we found that mitochondrial complex I gene expression, complex I activity, and cellular ATP levels were much higher in fully pluripotent stem cell lines than in partially pluripotent stem cell lines.

Long Noncoding RNA (lncRNA) HOTAIR Affects Tumorigenesis and Metastasis of Non-Small Cell Lung Cancer by Upregulating miR-613.

Non-small cell lung cancer (NSCLC) is one of the most deadly cancers with poor prognosis. Recent findings suggested that the lncRNA HOTAIR played an important role in tumorigenesis and metastasis. In the present study, HOTAIR was highly expressed in NSCLC tumor tissues and cell lines (H1299, H23, H292, and A549).

Novel Integration of Frame Rate Up Conversion and HEVC Coding Based on Rate-Distortion Optimization.

Frame rate up conversion (FRUC) can improve the visual quality by interpolating new intermediate frames. However, high frame rate videos by FRUC are confronted with more bitrate consumption or annoying artifacts of interpolated frames. In this paper, a novel integration framework of FRUC and high efficiency video coding (HEVC) is proposed based on rate-distortion optimization, and the interpolated frames can be reconstructed at encoder side with low bitrate cost and high visual quality.

Treatment adherence and disease burden of individuals with rheumatic diseases admitted as outpatients to a large rheumatology center in Shanghai, China.

Purpose: The purpose of this study was to determine treatment adherence and disease burden, analyze detailed medication problems experienced by patients, and identify factors associated with adherence in patients with rheumatic diseases in China.

Patients And Methods: Patients with confirmed diagnoses of ankylosing spondylitis (AS), rheumatoid arthritis (RA), and systemic lupus erythematosus (SLE) were recruited, regardless of demographics, disease severity, and treatment characteristics. Adherence was assessed using the Compliance Questionnaire for Rheumatology and interview-based self-reports.

Emodinol ameliorates urate nephropathy by regulating renal organic ion transporters and inhibiting immune inflammatory responses in rats.

Emodinol, 1β, 3β, 23-trihydroxyolean-12-en-28-acid, as the main active ingredient firstly extracted from the rhizomes of Elaeagus pungens by our Research Group, was identified with apparent uricosuric and nephroprotective effects in hyperuricemia mice in our previous study. This study aimed to investigate the renal protective effect of emodinol in urate nephropathy rats. Rats were orally administrated by combined adenine and ethambutol to induce urate nephropathy.

Correction: A dual-ion electrochemistry deionization system based on AgCl-NaMnO electrodes.

Correction for 'A dual-ion electrochemistry deionization system based on AgCl-NaMnO electrodes' by Fuming Chen et al., Nanoscale, 2017, 9, 10101-10108.

Identification of Novel Epitopes with Agonistic Activity for the Development of Tumor Immunotherapy Targeting TRAIL-R1.

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) receptor-1/2 (TRAIL-R1/R2), also known as death receptors, are expressed in a wide variety of tumor cells. Although TRAIL can induce cell apoptosis by engaging its cognate TRAIL-R1/R2, some tumor cells are or become resistant to TRAIL treatment. Monoclonal antibodies (mAbs) against TRAIL-R1/R2 have been developed to use as potential antitumor therapeutic agents instead of TRAIL.

A Prussian blue anode for high performance electrochemical deionization promoted by the faradaic mechanism.

Desalination is a sustainable process that removes sodium and chloride ions from seawater. Herein, we demonstrate a faradaic mechanism to promote the capacity of capacitive deionization in highly concentrated salt water via an electrochemical deionization device. In this system, ion removal is achieved by the faradaic mechanism via a constant current operation mode, which is improved based on the constant voltage operation mode used in the conventional CDI operation.

All-trans retinoic acid induces autophagic degradation of ubiquitin-like modifier activating enzyme 3 in acute promyelocytic leukemia cells.

All-trans retinoic acid (ATRA) has demonstrated notable success in the treatment of acute promyelocytic leukemia (APL) by inducing granulocytic differentiation. The underlying mechanisms of ATRA therapeutic effects have not been entirely clarified. Here, we reported that the regulation of neddylation, a ubiquitination-like post-translational modification, was involved in the treatment of ATRA on APL.

Switching of the substrate specificity of protein tyrosine phosphatase N12 by cyclin-dependent kinase 2 phosphorylation orchestrating 2 oncogenic pathways.

The protein tyrosine phosphatase nonreceptor type 12 (PTPN12) is a multifunctional protein and has elicited much research attention because its decreased protein level has been associated with poor prognosis of several types of cancers. Recently, we have solved the crystal structure of the phosphatase domain of PTPN12, which disclosed a specific PTPN12-insert-loop harboring a cyclin-dependent kinase 2 (CDK2) phosphorylation site. However, the functional significance of this phosphorylation is undefined.

Maximum likelihood estimation based regression for multivariate calibration.

In this paper, we propose a maximum likelihood estimation based regression (MLER) model for multivariate calibration. The proposed MLER method seeks for the maximum likelihood estimation (MLE) solution of the least-squares problem, and it is much more robust to noise or outliers and accurate than the traditional least-squares method. An efficient iteratively reweighted least squares technique is proposed to solve the MLER model.

A dual-ion electrochemistry deionization system based on AgCl-NaMnO electrodes.

Novel desalination technologies with high ion removal capacity and low energy consumption are desirable to tackle the water shortage challenge. Herein, we report a dual-ion electrochemistry deionization (DEDI) system with silver chloride as the electrochemical chloride release/capture anode, sodium manganese oxide as the electrochemical sodium release/capture cathode, and flow salt solution as the electrolyte. Sodium and chloride ions are synergistically released to the flow electrolyte feed at an applied positive current.

Nursing Management of Lumbar Drainage in Cryptococcal Meningitis: A Case Report.

Raised intracranial pressure is a hallmark of cryptococcal meningitis and is associated with increased mortality. Continuous drainage of lumbar cerebrospinal fluid is suggested to control intracranial pressure. The complications induced by this treatment have been described.

NOSH-NBP, a Novel Nitric Oxide and Hydrogen Sulfide- Releasing Hybrid, Attenuates Ischemic Stroke-Induced Neuroinflammatory Injury by Modulating Microglia Polarization.

NOSH-NBP, a novel nitric oxide (NO) and hydrogen sulfide (HS)-releasing hybrid, protects brain from ischemic stroke. This study mainly aimed to investigate the therapeutic effect of NOSH-NBP on ischemic stroke and the underlying mechanisms. , transient middle cerebral artery occlusion (tMCAO) was performed in C57BL/6 mice, with NO-NBP and HS-NBP as controls.

The temperature dependence of adsorption coefficients of Rn on activated charcoal: an experimental study.

The radon adsorption coefficient of activated charcoal (K) has exponential relationship with temperature theoretically, but few experiment results of K at temperature below 0 ℃ were given. In this study, K were measured using a flow-through system with activated charcoal in cylindrical adsorption beds at temperature adjusted from room temperature to -48°C using liquid nitrogen. Results are consistent with theory and show that the adsorption coefficient at -48°C is nearly 25 times higher than that at 23 ℃.