Safe controller design for circular motion of a bicycle robot using control Lyapunov function and control barrier function.

This paper investigates the safety control problem of a bicycle robot with front-wheel drive and without a trail or mechanical regulator during circular motion. Constraints on the drive angular speed necessary for the bicycle to achieve circular motion are proposed. In practical robot systems, bounded input disturbances are inevitable.

Proteomic profiling reveals the significance of lipid metabolism in small cell lung cancer recurrence and metastasis.

Background: Small cell lung cancer (SCLC) is a lethal and recalcitrant malignancy with early metastases. However, the molecular and cellular mechanisms underlying its aggressive characteristics remain relatively elusive.

Methods: In this study, we conducted a comprehensive proteomic analysis of 90 primary tumors, 15 patient-matched lymph node metastatic tumors, and 15 brain metastatic tumors derived from a cohort of 105 SCLC patients.

Multimodal monitoring of cerebral perfusion in carotid endarterectomy patients: a computational fluid dynamics study.

Objective: To evaluate postoperative cerebral perfusion changes and their influencing factors in carotid endarterectomy (CEA) patients by integrating multimodal monitoring methods, including cerebral regional oxygen saturation (rSO), carotid ultrasound (CU), computed tomographic angiography (CTA), and computed tomographic perfusion imaging (CTP), with computational fluid dynamics (CFD) assessment.

Methods: We conducted a cohort study on patients with internal carotid artery (ICA) stenosis undergoing CEA at our institution. Pre- and postoperative assessments included CU, CTA, CTP, and rSO monitoring.

Mitigation PFHxA-induced neurotoxicity in Carassius auratus brain cells by selenium-enriched Bacillus subtilis via the BDNF/PI3K/AKT/GSK-3β pathway.

As emerging contaminants growing threat to aquatic organisms, explore effective mitigation strategies is particularly important. Our previous studies have shown that selenium-rich Bacillus subtilis can not only alleviate the cause of brain damage by perfluorohexanoic acid (PFHxA) in Carassius auratus via the intestinal axis of the brain, but its metabolites can also alleviate PFHxA toxicity. This study further explores the potential mechanism through in vitro experiments.

Contrastive machine learning reveals species -shared and -specific brain functional architecture.

A deep comparative analysis of brain functional connectome across species in primates has the potential to yield valuable insights for both scientific and clinical applications. However, the interspecies commonality and differences are inherently entangled with each other and with other irrelevant factors. Here we develop a novel contrastive machine learning method, called shared-unique variation autoencoder (SU-VAE), to allow disentanglement of the species-shared and species-specific functional connectome variation between macaque and human brains on large-scale resting-state fMRI datasets.

Prognostic value of serum Mrp 8/14 in sepsis-induced acute respiratory distress syndrome patients: a retrospective cohort study.

Background: Mrp 8/14 is abundantly secreted by activated neutrophils during infection and inflammation. However, its prognostic value in acute respiratory distress dyndrome (ARDS) induced by sepsis is poorly understood. Our aim was to investigate the relationship between serum Mrp 8/14 and the prognosis in sepsis-induced ARDS patients admitted to the intensive care unit (ICU).

Comprehensive analysis of the transcription factor CREB3L4/RASEF signaling axis in lung adenocarcinoma: implications for pathogenesis and therapeutic strategies.

Objectives: This study aims to elucidate the role of cAMP responsive element binding protein 3 like 4 (CREB3L4) in the pathogenesis of lung adenocarcinoma (LUAD) and to provide new insights and approaches for its effective treatment. An analysis was conducted on the expression and prognostic implications of CREB3L4 in LUAD.

Methods: Potential downstream target genes regulated by CREB3L4 were identified through chromatin immunoprecipitation assay sequencing and mRNA sequencing analyses, and the regulatory relationship, mechanism, and prognostic significance of the identified target gene in LUAD were subsequently confirmed.

Improvement of Electrochemical Performance with Cetylpyridinium Chloride for the Al Anode of Alkaline Al-Air Batteries.

Aluminum-air batteries (AABs) are considered among high-power battery systems with various potential applications. However, the strong self-corrosion of Al in alkaline electrolytes negatively affects its Coulombic efficiency and significantly limits their large-scale application. This work presents the use of cetylpyridinium chloride (CPC) as an inexpensive and environmentally benign electrolyte additive in alkaline AABs.

Delivery of FBXO6 with highly branched poly(β-amino ester)s to modulate the inflammatory environment for the treatment of osteoarthritis.

Osteoarthritis (OA) is a chronic joint disease characterized by the progressive degradation of articular cartilage. Delivering functional genes to chondrocytes to modulate the inflammatory environment offers a promising approach to treating OA. However, the dense extracellular matrix (ECM) in the OA microenvironment and the rapid clearance of naked nucleic acids from synovial fluid present significant challenges.

Predictive value of longitudinal systemic inflammatory markers for pathologic response to neoadjuvant PD-1 blockade in resectable non-small cell lung cancer.

Background: Identifying biomarkers to predict responses for neoadjuvant immunotherapy in resectable non-small cell lung cancer (NSCLC) is under intensive study. Considering the interplay between cancer, inflammation, and immunosuppression, we hypothesized that circulating and imaging inflammatory markers could serve as indicators of anti-tumor immune responses, and thus conducting an exploratory study to reveal the predictive value of combining longitudinal systemic inflammatory markers in stratifying pathologic response to neoadjuvant sintilimab.

Methods: We retrospectively reviewed 36 patients (29 male and seven female) with NSCLC (stage IA-IIIB) who underwent pre- and post-treatment peripheral blood tests and F-fluorodeoxyglucose positron emission tomography/computed tomography (F-FDG PET/CT) scans before and after two cycles of neoadjuvant sintilimab (registration number: ChiCTR-OIC-17013726).

Synthesis and Mechanism Study of an Environmental Additive Used in Water-Based Drilling Fluids from Bovine Bone Glue.

At present, animal bone glue has been widely used in industry, but there are no relevant research reports on its application in the petroleum industry. In this paper, the rheological properties, inhibition, filtration, and temperature resistance performance of modified bone glue (Mbg) were evaluated in water-based drilling fluids, and the results showed that Mbg can significantly affect the performance of water-based muds with minimal dosage, and temperature resistance of Mbg could reach up to 130 °C. The inhibition mechanism of Mbg in drilling fluids was investigated by infrared spectroscopy (FT-IR), X-ray diffraction (XRD), zeta potential, thermogravimetric analysis (TGA), and scanning electron microscope (SEM).

Using SiO-Supported MnO@FeO Composite to Catalytically Decompose Waste Drilling Fluids Through Fenton-like Oxidation.

Waste drilling fluids produced from oil extraction can cause serious harm to the ecological environment; thus, the treatment of waste drilling fluids is urgent and important to ensure the sustainability and development of the oil extraction. In this work, we used the Fenton-like reaction method to degrade waste drilling fluids with SiO-supported MnO@FeO composite material as a catalyst in the presence of HO. During the Fenton-like reaction process, the MnO@FeO interface exhibits exceptional activity by facilitating the production of ·OH species with high activity and strong oxidizing properties, which degrade the organic substances in the waste drilling fluids into smaller inorganic molecules, thereby reducing its COD value.

Bioinformatics and Expression Analyses of the Gene Subfamily in Wheat ( L.).

Amino acids are the main form of nitrogen in plants, and their transport across cell membranes relies on amino acid transporters (AATs). Among the plant AATs, the TaATLa subfamily comprises 18 members, yet the bioinformatics characteristics and functions of genes in common wheat remain poorly understood due to their complex genomes. This study performed genomic analyses of .

Implementation of an indoor optical camera communication and localization fusion system using infrared LED markers.

Recently, with the development of communication and positioning technologies, progressively higher demands have been placed on the timeliness of indoor communication and the effectiveness of indoor positioning. This paper proposes a low-cost and full-time domain coverage indoor communication and localization fusion system that uses an infrared camera to identify mobile LEDs based on region of interest optical camera communication (RoI-OCC) and calculate three-dimensional (3D) world coordinates based on perspective-n-point (PnP) algorithm. An intermediate delimiter modulation-demodulation method is designed to achieve asynchronous OCC.

Brain functional gradients are related to cortical folding gradient.

Cortical folding is closely linked to brain functions, with gyri acting more like local functional "hubs" to integrate information than sulci do. However, understanding how anatomical constraints relate to complex functions remains fragmented. One possible reason is that the relationship is estimated on brain mosaics divided by brain functions and cortical folding patterns.

A Prospective and Comparative Study to Explore the Effects of Platelet-Rich Plasma in Hair Transplantation for Patients With Androgenetic Alopecia.

Background: Androgenetic alopecia (AGA) is the most prevalent type of hair loss. Traditionally, treatment for AGA has primarily involved the topical application of minoxidil in conjunction with oral finasteride or spironolactone. Recently, platelet-rich plasma (PRP) has emerged as a significant focus of research in hair loss treatment.

Effect of High Nighttime Temperatures on Growth, Yield, and Quality of Two Wheat Cultivars During the Whole Growth Period.

It is a consensus that Earth's climate has been warming. The impact of global warming is asymmetric, that is, there is more substantial warming in the daily minimum surface air temperature and lower warming in the maximum surface air temperature. Previous studies have reported diurnal temperature differences greatly affecting winter wheat yield.

Effects of BET Surface Area and Silica Hydrophobicity on Natural Rubber Latex Foam Using the Dunlop Process.

To reinforce natural rubber latex foam, fumed silica and precipitated silica are introduced into latex foam prepared using the Dunlop process as fillers. Four types of silica, including Aerosil 200 (hydrophilic fumed silica), Reolosil DM30, Aerosil R972 (hydrophobic fumed silica), and Sipernat 22S (precipitated silica), are investigated. The latex foam with added silica presents better mechanical and physical properties compared with the non-silica foam.

Enhancing the viscoelastic properties of bacterial cellulose hydrogels through ultrasonic and enzymatic modification of xyloglucan.

Bacterial cellulose (BC) hydrogels exhibit nanofibril porous network with good viscoelasticity for use as food ingredients and medical materials. Xyloglucan (XG), a hemicellulose with branching residues, can hybridize with BC to improve the hydrogel's extensibility. Thus, modifying the molecular structure of XG can fine-tune the viscoelastic properties of BC hydrogels.

-Selective Carboacylation of Alkynes via Photoredox/Nickel Dual Catalysis.

Here, we report an intermolecular carboacylation of terminal alkynes with tertiary and secondary alkyltrifluoroborates as well as acyl chlorides via photoredox/nickel dual catalysis, affording a varity of stereodefined trisubstituted enones in good to excellent yields and stereoselectivity, through a radical relay process. This redox-neutral protocol exhibits excellent functional group tolerance, exclusive regio- and stereoselectivity, and broad compatibility with various acyl chlorides and alkyltrifluoroborates.