Metallic vanadium activated by an dissolution-deposition process for a superior aqueous zinc ion battery cathode.

Metallic vanadium is innovatively introduced for a superior aqueous zinc-ion battery cathode material, which is activated through dissolution-deposition transition to amorphous VO·3HO and delivers an excellent capacity of 610 mA h g at 0.1 A g and remarkable capacity retention rate of 80.3% after 1000 cycles at 1 A g.

Discovery and Total Synthesis of a New Class of Minor Immunosuppressive Plant Sesterterpenoids.

Plant sesterterpenoids are an extremely rare family of natural products that generally possess novel chemical structures and diverse biological activities. Here, we report the discovery of an unprecedented group of minor plant sesterterpenoids, gracilisoids B-E (2-5), which feature two types of highly functionalized bicyclo[3.2.

From Monocyclization to Pentacyclization: A Versatile Plant Cyclase Produces Diverse Sesterterpenes with Anti-Liver Fibrosis Potential.

A prolific multi-product sesterterpene synthase CbTPS1 is characterized from the medicinal Brassicaceae plant Capsella bursa-pastoris. Twenty different sesterterpenes including 16 undescribed compounds, possessing 10 different mono-/di-/tri-/tetra-/penta-carbocyclic skeletons, including the unique 15-membered macrocyclic and 24(15→14)-abeo-capbuane scaffolds, are isolated and structurally elucidated from engineered Escherichia coli strains expressing CbTPS1. Site-directed mutagenesis assisted by molecular dynamics simulations resulted in the variant L354M with up to 13.

Baolier Capsule's Secret Weapon: Piperine Boosts Cholesterol Excretion to Combat Atherosclerosis.

Purpose: The Baolier capsule (BLEC) is a proprietary Mongolian medicine administered for treating hypercholesterolemia and atherosclerosis (AS). However, the therapeutic effects, primary bioactive ingredients, and potential mechanisms underlying hypercholesterolemia and AS remain unclear. This study aimed to investigate the pharmacological effects, principal active ingredients, and mechanisms of BLEC against hypercholesterolemia and AS.

Halide-free ion pair organocatalyst from biobased α-hydroxy acid for cycloaddition of CO to epoxide.

The cycloaddition of CO to epoxide (CCE) reactions produce valuable cyclic carbonates useful in the electrolytes of lithium-ion batteries, as organic solvents, and in polymeric materials. However, halide-containing catalysts are predominantly used in these reactions, despite halides being notoriously corrosive to steel processing equipment and residual halides also having harmful effects. To eliminate the reliance on halides as cocatalyst in most CCE reactions, halide-free catalysts are highly desirable.

Defluorinative Cyclization of Enamides with Fluoroalkyl Halides Through Two Vicinal C(sp)─F Bonds Functionalization.

Introducing distinctive functional groups to expand the structural diversity and improve the intrinsic properties of parent molecules has been an essential pursuit in organic chemistry. By using perfluoroalkyl halide (PFAH) as a nontraditional, readily available, ideal 1,2-difluoroalkenyl coupling partner, a defluorinative cyclization reaction of enamides for the construction of fluoroalkenyl oxazoles is first developed. The selective and controllable two-fold cleavage of vicinal C(sp)─F bonds in PFAH not only enables the introduction of a specific 1,2-difluoroalkenyl moiety with ease but also results in the functionalization of two C(sp)─H bonds of enamides without the need for metal catalyst, photocatalyst, oxidant, or light.

Predictive value of trendelenburg position and carotid ultrasound for fluid responsiveness in patients on VV-ECMO with acute respiratory distress syndrome in the prone position.

Fluid administration is widely used to treat hypotension in patients undergoing veno-venous extracorporeal membrane oxygenation (VV-ECMO). However, excessive fluid administration may lead to fluid overload can aggravate acute respiratory distress syndrome (ARDS) and increase patient mortality, predicting fluid responsiveness is of great significance for VV-ECMO patients. This prospective single-center study was conducted in a medical intensive care unit (ICU) and finally included 51 VV-ECMO patients with ARDS in the prone position (PP).

ADSCs-derived exosomes suppress macrophage ferroptosis via the SIRT1/NRF2 signaling axis to alleviate acute lung injury in sepsis.

Acute lung injury being one of the earliest and most severe complications during sepsis and macrophages play a key role in this process. To investigate the regulatory effects and potential mechanisms of adipose mesenchymal stem cell derived-exosomes (ADSC-exo) on macrophages and septic mice, ADSCs-exo was administrated to both LPS-induced macrophage and cecal ligation and puncture (CLP) induced sepsis mice. ADSCs-exo was confirmed to inhibit M1 polarization of macrophages and to reduce excessive inflammation.

Effects of TGase on the rheological behaviors, structural properties and molecular forces of cowpea protein isolate and cowpea albumin gels.

The effects of TGase on hardness, water holding capacity (WHC), molecular forces, structural properties, microstructure and rheological behaviors of TGase-induced cowpea protein isolate gel (T-CPIG) and cowpea albumin gel (T-CPAG) were investigated. TGase significantly increased the hardness of gels and the most stable three-dimensional network structures were formed by adding 20 U/g and 28 U/g. Not only the non-network structure proteins of gels and free sulfhydryl groups were fewer but also the β-fold and β-angle relative contents were higher than cowpea protein isolate (CPI) and cowpea albumin (CPA).

Electrochemical Reductive Bimolecular Cycloaddition of 2-Arylideneindane-1,3-diones for the Synthesis of Spirocyclopentanole Indane-1,3-diones.

An electrochemical reductive bimolecular cycloaddition of 2-arylideneindane-1,3-diones has been reported for the synthesis of spirocyclopentanole indane-1,3-diones bearing five contiguous stereocenters with vicinal tetrasubstituted stereocenters, especially involving a quaternary carbon center, in moderate to good yields and excellent diastereoselectivities. The present protocol features mild reaction conditions, no external chemical redox reagents, excellent atom economy, and gram-scale synthesis. In addition, a mechanistic investigation indicates that the reactions proceed through a radical pathway.

Identification of Mycobacterium marinum in subcutaneous abscesses of an infected patient's foot.

Introduction: Mycobacterium marinum is a well-known pathogenic non-tuberculous mycobacterium for skin and soft tissue infections. Infection, often presenting as superficial lesions, is seen after exposure of skin abrasions to contaminated water or infected fish and is known as "swimming pool" or "fish tank" granuloma. This study reported a case of M.

"One-Pot" Synthesized Phosphorus Corrole-Based Metal-Organic Frameworks for Synergistic Phototherapy and Chemodynamic Therapy.

As a distinctive class of porphyrin derivatives, corroles offer exceptional potential in phototherapy applications owing to their unique electronic structures. However, developing metal-organic frameworks (MOFs) that incorporate photosensitive corroles as functional ligands for synergistic phototherapy remains a formidable challenge. Herein, for the first time, the unique phosphorus corrole-based MOFs Cor(P)-Hf with (3,18)-connected gea topology are reported, which are constructed by Cs-symmetric dicarboxylate 3-connected linkers, 10-pentafluorophenyl-5,15-di(p-benzoate)phosphorus corrole (Cor(P)), and the peculiar D-symmetric 18-connected Hf-oxo clusters.

Development a risk prediction nomogram for multidrug-resistant bacterial and fungal infection in gastrointestinal fistula patients during the perioperative period.

Background: This study aims to develop a risk prediction model for multidrug-resistant bacterial and fungal infections in patients with gastrointestinal fistulas during the perioperative period.

Methods: A retrospective cohort study was conducted at Anhui No. 2 Provincial People's Hospital from January 2022 to July 2024.

An active shrinkage and antioxidative hydrogel with biomimetic mechanics functions modulates inflammation and fibrosis to promote skin regeneration.

Achieving scar-free skin regeneration in clinical settings presents significant challenges. Key issues such as the imbalance in macrophage phenotype transition, delayed re-epithelialization, and excessive proliferation and differentiation of fibroblasts hinder wound healing and lead to fibrotic repair. To these, we developed an active shrinkage and antioxidative hydrogel with biomimetic mechanical functions (P&G@LMs) to reshape the healing microenvironment and effectively promote skin regeneration.

Customized Sized Manganese Sulfide Nanospheres as Efficient T MRI Contrast Agents for Enhanced Tumor Theranostics.

The impact of nanoparticle size on the effectiveness of magnetic resonance imaging (MRI) using sulfurized manganese nanoparticles (MnS@PAA) stabilized with polyacrylic acid (PAA) as a binder was thoroughly investigated. MnS@PAA nanoparticles of varying sizes were synthesized by altering the ratio of ethylene glycol (EG) to diethylene glycol (DEG) during the synthesis process. These nanoparticles exhibited a uniform size distribution and demonstrated high T relaxation rates, along with a notable pH-responsive behavior.

Identification of Cuproptosis-Related Patterns Predict Prognosis and Immunotherapy Response in Hepatocellular Carcinoma.

A novel copper-dependent mode of death, cuproptosis, has been newly identified. This study developed a cuproptosis score (CS) based on the cuproptosis model to analyse the association of CS with prognosis, immune cell infiltration, drug sensitivity and immunotherapy response in hepatocellular carcinoma (HCC) patients. A typing model of cuproptosis was constructed based on the expression of 19 cuproptosis-related genes (CRGs).

Shape unrestricted topological corner state based on Kekulé modulation and enhanced nonlinear harmonic generation.

Topological corner states have been extensively utilized as a nanocavity to increase nonlinear harmonic generation due to their high -factor and robustness. However, the previous topological corner states based nanocavities and nonlinear harmonic generation have to comply with particular spatial symmetries of underlying lattices, hindering their practical application. In this work, we design a photonic nanocavity based on shape unrestricted topological corner state by applying Kekulé modulation to a honeycomb photonic crystal.

[Castleman disease in the parapharyngeal space: a case report].

Castleman's disease is a group of heterogeneous lymphoproliferative disorders with unclear etiology and pathogenesis.This article reports a case of Castleman's disease of the parapharyngeal space, with a comprehensive literature review of the clinical feature and typing, pathologic diagnosis, treatment, and prognosis of the disease.This case is a unicentric type, which is clinically characterized by significant enlargement of lymph nodes without systemic symptoms.

Co-pyrolysis behaviors, kinetics, and thermodynamics of sludge, lignite and biomass through fixed-bed reactor experiments and thermogravimetric analysis.

Co-pyrolysis behaviors, kinetics, and thermodynamic parameters of petrochemical sludge (PS), lignite (HL), and pine wood (PW) were investigated via fixed-bed reactor experiments and thermogravimetric analysis. Fixed-bed experiments showed H and CO were main gases from PS, HL, and blends, CO from PW and PS, and CO and CH from PS and HL. Thermal analysis indicated that ternary blends' de-volatilization had two parts dominated by PW and HL, respectively.

Simulation study on supercontinuum broadening based on the BIC model.

Bound states in the continuum (BIC) refers to waves that are entirely confined within the continuous spectrum of radiation waves without interacting with them. In our study, we attempted to construct a waveguide satisfying BIC conditions by forming a polymer layer on a 4H-SiC substrate, positioned on an insulator. By fine-tuning the waveguide parameters, we minimized losses to the substrate continuum and determined that the lowest loss meeting BIC conditions occurs when the HSQ width is 1.

Clinical and Sonographic Differences between RET Fusion-Positive and BRAFV600E in Papillary Thyroid Carcinoma.

Purpose: This study aimed to describe the ultrasound characteristics of papillary thyroid carcinoma (PTC) harboring RET gene fusion and explore its clinical significance.

Methods: A retrospective study was conducted on 209 patients with PTC diagnosed between Aug 2021 and Jan 2024. All patients underwent ultrasound examination and were confirmed to be positive for RET fusion or BRAFV600E by pathological results.

The clinical significance of the Neutrophil-to-Lymphocyte Ratio as a novel inflammatory biomarker for assessing the severity of intervertebral disc degeneration.

Purpose: Inflammation is integral to the pathogenesis of intervertebral disc degeneration, yet the role of systemic inflammatory markers in this process remains underexplored. This study aims to explore the association between the Neutrophil-to-Lymphocyte Ratio (NLR) and the severity of disc degeneration.

Patients And Methods: A retrospective analysis was conducted on 375 patients diagnosed with lumbar disc degeneration between April 2018 and May 2021.