Transcatheter mitral valve replacement to treat rheumatic mitral stenosis: a case series.

Background: Rheumatic mitral stenosis (RMS) is a common valvular heart disease in developing countries. We sought to evaluate the early experience of patients with RMS undergoing transcatheter mitral valve replacement (TMVR).

Methods: In this retrospective study, a total of 5 RMS patients accepted TMVR.

Research Progress on the Mechanism and Application of the Type I CRISPR-Cas System.

The CRISPR-Cas system functions as an adaptive immune mechanism in archaea and bacteria, providing defense against the invasion of foreign nucleic acids. Most CRISPR-Cas systems are classified into class 1 or class 2, with further subdivision into several subtypes. The primary distinction between class 1 and class 2 systems lies in the assembly of their effector modules.

Influence of Relative Humidity on the Mechanical Properties of Palm Leaf Manuscripts: Short-Term Effects and Long-Term Aging.

Palm leaf manuscripts are a valuable part of world cultural heritage. Studying the mechanical properties of palm leaf manuscripts and their changes due to environmental influences is of great significance for understanding the material characteristics, aging mechanisms, and preventive conservation of these manuscripts. This study used dynamic vapor sorption (DVS) and a thermomechanical analyzer (TMA) to investigate the changes to the mechanical properties of palm leaf manuscripts in response to different relative humidity conditions and different time periods.

Collection methods of exhaled volatile organic compounds for lung cancer screening and diagnosis: a systematic review.

Background: The identification of volatile organic compounds (VOCs) in exhaled breath has garnered significant research attention as a means of screening and diagnosing lung cancer in recent decades. However, there is no universally accepted protocol for the collection of breath samples to measure VOCs in the clinical context. The purpose of this study was to summarize the current sampling techniques used to obtain VOCs from exhaled breath specifically in the context of lung cancer screening and diagnosis.

Examining the relationship between CDAI and frailty and its manifestation in Parkinson's disease: a cross-sectional study.

Background: Higher intake of antioxidants is associated with reduced risk of various chronic diseases. However, the relationship between composite dietary antioxidants and frailty has not been characterized, especially in neurodegenerative conditions like Parkinson's disease (PD) where frailty is highly prevalent. This study aimed to investigate the association between composite dietary antioxidant index (CDAI), a composite score reflecting antioxidant vitamin and mineral intakes, and frailty risk in the general United States (US) population and PD patients.

Application of isotope and multi-element fingerprinting in subregional milk authentication - The case of Ningxia, China.

Traceability of origin enhances the branding and safety of agricultural products. This study developed a subregional milk origin tracing method by selecting thirty large-scale farms: twenty-seven in Ningxia and three in Beijing. The farms were classified into six groups based on subregions: A (Yinchuan), B (Shizuishan), C (Qingtongxia), D (Yanchi), E (Zhongwei), and F (Beijing).

Predicting hypoglycemia in elderly inpatients with type 2 diabetes: the ADOCHBIU model.

Background: Hypoglycemic episodes cause varying degrees of damage in the functional system of elderly inpatients with type 2 diabetes mellitus (T2DM). The purpose of the study is to construct a nomogram prediction model for the risk of hypoglycemia in elderly inpatients with T2DM and to evaluate the predictive performance of the model.

Methods: From August 2022 to April 2023, 546 elderly inpatients with T2DM were recruited in seven tertiary-level general hospitals in Beijing and Inner Mongolia province, China.

Microbial Diversity and Biodegradation Mechanism of Microorganisms in the Dingtao M2 Tomb.

The Dingtao M2 tomb, the largest and best-preserved imperial "Huangchangticou" tomb in China, holds great significance for its conservation. Currently, varying degrees of microbial degradation are occurring on the surfaces of the M2 tomb. This study aimed to determine the microbial diversity of the M2 tomb and its surrounding environment during July 2021 and August 2022.

Preliminary Study on Type I Interferon as a Mucosal Adjuvant for Human Respiratory Syncytial Virus F Protein.

Human respiratory syncytial virus (HRSV) imposes a significant disease burden on infants and the elderly. Intranasal immunization using attenuated live vaccines and certain vector vaccines against HRSV has completed phase II clinical trials with good safety and efficacy.Recombinant protein vaccines for mucosal immunization require potent mucosal adjuvants.

Indocyanine green fluorescence imaging for lymph node detection and long-term clinical outcomes in colorectal cancer surgery: A systematic review and meta-analysis.

Background: The indocyanine green fluorescence imaging (ICG-FI) technique is increasingly being used in laparoscopic colorectal surgery for lymph node mapping. However, there is no definitive standard regarding whether the application of this technique can significantly increase the detection rate of metastatic lymph nodes and improve long-term prognosis.

Methods: PubMed, Embase, Web of Science, and Cochrane Library databases were searched to include studies including ICG-FI in laparoscopic colorectal surgery.

A nomogram for cancer-specific survival of lung adenocarcinoma patients: A SEER based analysis.

Background: Non-small cell lung cancer (NSCLC) accounts for 85 % of lung cancer cases. Among NSCLC subtypes, lung adenocarcinoma (LUAD) stands as the most prevalent. Regrettably, LUAD continues to exhibit a notably unfavorable overall prognosis.

Microstructure and Properties of Aluminum Alloy/Diamond Composite Materials Prepared by Laser Cladding.

In this article, AlSi10Mg aluminum alloy was used as the substrate to prepare aluminum alloy/diamond composite materials with laser cladding technology. The effects of the composition and laser power on the microstructure and thermal properties of the composite materials were studied. The results show that the prefabrication of tungsten carbide layer on the diamond surface enhances the wettability of diamond with aluminum alloy and reduces the laser reflection, which ensures the implementability of laser cladding technology for the preparation of aluminum alloy/diamond composites.

From inflammation to depression: key biomarkers for IBD-related major depressive disorder.

Background: Inflammatory bowel disease (IBD) is a chronic, inflammatory, and autoimmune disorder, and its incidence of comorbid with major depressive disorder (MDD) is significantly higher than the general population. However, many patients lack proper recognition and necessary psychological health treatments. We aimed to identify potential biomarkers and mechanisms involved in the development of IBD comorbid with MDD (IBD-MDD).

Association between serum per- and polyfluoroalkyl substances levels and metabolic dysfunction-associated steatotic liver disease.

Experimental evidences have suggested that Per- and polyfluoroalkyl substances (PFASs) were hepatotoxicity, but epidemiologic inconsistencies. There were 1751 participants included in this study after excluding chronic hepatitis, cirrhosis, excessive alcohol drinkers, and those with missing key variables. Totally 30 PFASs were quantified using ultrahigh-pressure liquid chromatography tandem mass spectrometer (UPLC-MS).

Case report: Asymmetric bilateral deep brain stimulation for the treatment of pantothenate kinase-associated neurodegeneration in a patient: a unique case of atypical PKAN with a novel heterozygous PANK2 mutation.

Pantothenate kinase-associated neurodegeneration (PKAN) is a rare autosomal recessive hereditary neurodegenerative disorder, usually caused by mutations in the pantothenate kinase 2 (PANK2) gene. We report a young female patient with atypical PKAN, harboring a novel heterozygous PANK2 mutation, diagnosed through clinical imaging and genetic analysis. The patient presented with dystonia and motor dysfunction after onset, but early brain MRI showed normal findings.

Serum Microcystin-LR Levels Linked with Risk of Inflammatory Bowel Disease: A Matched Case-Control Study in China.

Microcystin-LR (MC-LR), the most prevalent and diverse cyanotoxin produced by harmful cyanobacterial blooms, has been linked to gastrointestinal toxicity. Therefore, we conducted a case-control study across four regions in China to investigate this relationship. Inflammatory bowel disease (IBD) cases (219) were matched with healthy controls (438) based on age and gender and conditional logistic regression models and Restricted cubic splines were used to evaluate the association between MC-LR exposure and IBD risk.

Fighting ischemia-reperfusion injury: Focusing on mitochondria-derived ferroptosis.

Ischemia-reperfusion injury (IRI) is a major cause of mortality and morbidity. Current treatments for IRI have limited efficacy and novel therapeutic strategies are needed. Mitochondrial dysfunction not only initiates IRI but also plays a significant role in ferroptosis pathogenesis.

Interstitial Oxygen Acts as Electronic Buffer Stabilizing High-Entropy Alloys for Trifunctional Electrocatalysis.

Understanding the effect of elements' oxygen affinity is essential for comprehending high-entropy alloys' (HEAs) complete properties. However, the origin of HEAs' oxygen-containing structure and stability remains poorly understood, primarily due to their diverse components, hindering synthesis and analysis. Herein, the O-doping HEAs (HEA-O) have demonstrated outstanding performance and stability in electrolyzed water and Zinc-air batteries which can be reassembled after being stable for more than 1600 h when the zinc consumption is over.

Effects of vitamin D supplementation on serum 25(OH)D levels and neurobehavioral development in premature infants after birth.

This study explored the factors influencing serum 25(OH)D levels and the effects of Vitamin D deficiency (VDD) and VD supplementation on 25(OH)D levels and neuropsychobehavioral development in premature infants, to provide a theoretical basis for improving their prognosis. Physical examination, neuropsychobehavioral development and serum 25(OH)D levels were assessed regularly in 158 preterm infants supplemented with VD formulation. 25(OH)D levels were analyzed at 3, 6, 9, 12, and 18 months after birth.