Development and validation of a machine-learning model for preoperative risk of gastric gastrointestinal stromal tumors.

Background: Gastrointestinal stromal tumors (GISTs) have malignant potential, and treatment varies according to risk. However, no specific protocols exist for preoperative assessment of the malignant potential of gastric GISTs (gGISTs). This study aimed to use machine learning (ML) to develop and validate clinically relevant preoperative models to predict the malignant potential of gGISTs.

A mesothelin microsensor based on an embedded thionine electronic medium within an imprinted polymer on an acupuncture needle electrode.

An electrochemical microsensor for mesothelin (MSLN) based on an acupuncture needle (AN) was constructed in this work. To prepare the microsensor, MSLN was self-assembled on 4-mercaptophenylboronic acid (4-MPBA) by an interaction force between the external -diol and phenylboronic acid. This was followed by the gradual electropolymerization of thionine (TH) and eriochrome black T (EBT) around the anchored protein.

To explore the pathogenesis of anterior resection syndrome by magnetic resonance imaging rectal defecography.

Background: Over 90% of rectal cancer patients develop low anterior resection syndrome (LARS) after sphincter-preserving resection. The current globally recognized evaluation method has many drawbacks and its subjectivity is too strong, which hinders the research and treatment of LARS.

Aim: To evaluate the anorectal function after colorectal cancer surgery by quantifying the index of magnetic resonance imaging (MRI) defecography, and pathogenesis of LARS.

Machine learning models predict lymph node metastasis in patients with stage T1-T2 esophageal squamous cell carcinoma.

Background: For patients with stage T1-T2 esophageal squamous cell carcinoma (ESCC), accurately predicting lymph node metastasis (LNM) remains challenging. We aimed to investigate the performance of machine learning (ML) models for predicting LNM in patients with stage T1-T2 ESCC.

Methods: Patients with T1-T2 ESCC at three centers between January 2014 and December 2019 were included in this retrospective study and divided into training and external test sets.

First Organic-Inorganic Hybrid Compounds Formed by Ge-V-O Clusters and Transition Metal Complexes of Aromatic Organic Ligands.

Three compounds based on Ge-V-O clusters were hydrothermally synthesized and characterized by IR, UV-Vis, XRD, ESR, elemental analysis and X-ray crystal structural analysis. Both [Cd(phen)(en)][Cd(phen)VOGe(OH)(HO)]∙12.5HO () and [Cd(DETA)][Cd(DETA)][Cd(phen)VOGe(OH)(0.

A disposable paper-based hydrophobic substrate for highly sensitive surface-enhanced Raman scattering detection.

Detection of target analytes with high sensitivity and reproducibility remains a challenge for surface-enhanced Raman scattering (SERS) due to the lack of cost-effective and highly sensitive substrates. In this study, a hydrophobic SERS substrate capable of concentrating nanoparticles and analytes was prepared by spin-coating lubricating liquid onto commercial paper. The condensation effect of the paper-based hydrophobic substrate induced aggregation of gold nanoparticles (Au NPs) to generate ''hot spots'' for SERS and to drive analytes to the hot-spot areas for more sensitive detection.

Development, validation and comparison of four methods for quantifying endogenous 25OH-D3 in human plasma.

To meet the increasing clinical needs for 25-hydroxyvitamin D3 (25OH-D3) detection, the development of an efficient and accurate high-performance liquid chromatography-mass spectrometry (HPLC-MS) method for plasma 25OH-D3 quantitation is important. Since 25OH-D3 is an endogenous compound, the lack of a plasma blank increases the difficulty of accurately quantifying 25OH-D3. Selection of a method suitable for clinical monitoring among various methods for endogenous compound quantification is necessary.

Recyclable three-dimensional Ag nanorod arrays decorated with O-g-CN for highly sensitive SERS sensing of organic pollutants.

A three-dimensional (3D) substrate was developed by assembling a monolayer of graphitic carbon nitride (O-g-CN) on Ag nanorod arrays (Ag NRs) for sensitive and recyclable surface enhanced Raman scattering (SERS) detection. The prepared Ag NRs/O-g-CN substrate not only generated a significant Raman enhancement effect as a result of the strong π-π stacking interaction between O-g-CN and the analytes but also possessed excellent self-cleaning property via visible-light irradiation that was attributed to its outstanding catalytic performance. Highly sensitive SERS detection could be achieved with a LOD of 8.

Removal of Antibiotics From Water with an All-Carbon 3D Nanofiltration Membrane.

Recent industrial developments and increased energy demand have resulted in significantly increased levels of environmental pollutants, which have become a serious global problem. Herein, we propose a novel all-carbon nanofiltration (NF) membrane that consists of multi-walled carbon nanotubes (MWCNTs) interposed between graphene oxide (GO) nanosheets to form a three-dimensional (3D) structure. The as-prepared membrane has abundant two-dimensional (2D) nanochannels that can physically sieve antibiotic molecules through electrostatic interaction.

An unprecedented antimonato-polyoxovanadate (SbPOV) based on both α-[VSbO] and β-[VSbO] isomers.

An unprecedented antimonato-polyoxovanadate (SbPOV) based on both α-[VSbO] and β-[VSbO] isomers has been hydrothermally synthesized.

Effective Removal of Tetracycline Antibiotics from Water using Hybrid Carbon Membranes.

Antibiotic residues in drinking water have become a global problem, especially in developing countries. However, effective purification of water contaminated by antibiotics remains a great challenge. Here, we investigated the removing of tetracycline by carbon nanomaterials with different structures and surface functionalities.

Highly Reproducible Ag NPs/CNT-Intercalated GO Membranes for Enrichment and SERS Detection of Antibiotics.

The increasing pollution of aquatic environments by antibiotics makes it necessary to develop efficient enrichment and sensitive detection methods for environmental antibiotics monitoring. In this work, silver nanoparticles and carbon nanotube-intercalated graphene oxide laminar membranes (Ag NPs/CNT-GO membranes) were successfully prepared for enrichment and surface-enhanced Raman scattering (SERS) detection of antibiotics. The prepared Ag NPs/CNT-GO membranes exhibited a high enrichment ability because of the π-π stacking and electrostatic interactions of GO toward antibiotic molecules, which enhanced the sensitivity of SERS measurements and enabled the antibiotics to be determined at sub-nM concentrations.

Tuning the structures based on polyoxometalates from 1-D to 2-D by using different secondary organic ligands.

Six new organic-inorganic hybrid compounds based on [XM12O40](4-) (X = heteroatom, M = metal atom), namely [Cu(pic)2][H2XM12O40]·2Hapy·2apy (X = Si, M = W for , X = Ge, M = W for and X = Si, M = Mo for ), [Cu(2,2'-bpy)2][Cu(2,2'-bpy)(H2O)][Cu(pic)2]0.5[XM12O40]·nH2O (X = Si, M = Mo, n = 0.5 for , X = Ge, M = W, n = 1 for ) and [Cu(phen)(H2O)]2[Cu(pic)2][GeW12O40]·2.

Polyoxometalate-based organic-inorganic hybrid compounds containing transition metal mixed-organic-ligand complexes of N-containing and pyridinecarboxylate ligands.

Five new organic–inorganic hybrid compounds based on the Keggin-type polyoxoanion [SiW12O40]4−, namely [Cu3(2,2′-bpy)3(inic)(μ2-OH)(H2O)][SiW12O40]·2H2O (1), [Cu6(phen)6(μ3-Cl)2(μ2-Cl)2Cl2(inic)2][SiW12O40]·6H2O (2), [Cu2(hnic)(2,2′-bpy)2Cl]2[H2SiW12O40] (3), [Cu2(nic)(phen)2Cl2]2[SiW12O40] (4) and [Cu2(pic)(2,2′-bpy)2Cl]2[SiW12O40] (5) (inic = isonicotinic acid, hnic = 2-hydroxy-nicotinic acid, nic = nicotinic acid, pic = picolinic acid, 2,2′-bpy = 2,2′-bipyridine, phen = 1,10-phenanthroline) have been synthesized and characterized by IR, UV-Vis, XPS, XRD, cyclic voltammetric measurements, photoluminescence analysis and single crystal X-ray diffraction analysis. Crystal analysis reveals that compound 1 exhibits a 2-D double layered framework structure constructed from [SiW12O40]4− and copper-aqua-2,2′-bipy-hydroxyl-isonicotinate complexes. Compound 2 is a 0-D discrete structure formed by [SiW12O40]4− and copper-chloro-isonicotinate-phenanthroline complexes.

Synthesis of MnO2 nanoparticles from sonochemical reduction of MnO4(-) in water under different pH conditions.

MnO2 was synthesized by sonochemical reduction of MnO4(-) in water under Ar atmosphere at 20°C, where the effects of solution pH on the reduction of MnO4(-) were investigated. The obtained XRD results showed that poor crystallinity δ-MnO2 was formed at pH 2.2, 6.

Sonochemical fabrication of gold nanoparticles-boron nitride sheets nanocomposites for enzymeless hydrogen peroxide detection.

A simple sonochemical route was developed for the preparation of gold nanoparticles/boron nitride sheets (AuNPs/BNS) nanocomposites without using reducing or stabilizing agents. Transmission electron microscopy, scanning electron microscopy, X-ray diffraction, and UV-vis absorption spectra were used to characterize the structure and morphology of the nanocomposites. The experimental results showed that AuNPs with approximately 20nm were uniformly attached onto the BNS surface.

Sonochemical fabrication of twinned ZnO hollow ellipses for electrochemical biosensing.

Twinned ZnO hollow ellipses (ZnO HEs) have been successfully fabricated by a one-step template-free sonochemical route. The products were characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM) and transmission electron microscopy (TEM). The results showed that the ZnO HEs had a hexagonal wurtzite structure, the wall of which was composed of ZnO nanorods.

Fabrication of a boron nitride-gold nanocluster composite and its versatile application for immunoassays.

A multifunctional boron nitride-gold nanocluster composite was fabricated using poly-diallyldimethylammonium chloride as a stabilizer and a linker. The as-fabricated composite could be used as a fluorescent or an electrochemical label for immunosensing in the sensitive detection of interleukin-6.

Microwave-assisted synthesis of highly luminescent AgInS/ZnS nanocrystals for dynamic intracellular Cu(ii) detection.

Low-toxicity, highly luminescent, and water-soluble AgInS/ZnS nanocrystals (NCs) have been synthesized via a microwave-assisted approach. The structure and optical features of the AgInS/ZnS NCs were characterized by X-ray diffraction, high resolution transmission electron microscopy, Fourier transform infrared spectroscopy, ultraviolet visible absorption spectroscopy and photoluminescence (PL) spectroscopy. The as-synthesized AgInS/ZnS NCs exhibited high PL quantum yields (40%) and long PL lifetimes (424.

One-step simple sonochemical fabrication and photocatalytic properties of Cu2O-rGO composites.

An easy, one-step synthesis of Cu2O-reduced graphene composites (Cu2O-rGO) was developed using a simple sonochemical route without any surfactants or templates. The morphology and structure of the Cu2O-rGO composites were characterised using techniques such as scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray diffraction (XRD), Fourier transform infrared (FT-IR) spectroscopy, Raman spectroscopy and X-ray photoelectron spectroscopy (XPS). The results indicated that the Cu2O sphere is approximately 200 nm in diameter and composed of small Cu2O particles approximately 20 nm in diameter.

Aqueous synthesis of color-tunable CuInS2/ZnS nanocrystals for the detection of human interleukin 6.

In this Article, we present a facile microwave-assisted synthesis route for the preparation of water-soluble and high-quality CuInS2/ZnS nanocrystals (NCs) with glutathione as the stabilizer. The as-prepared CuInS2/ZnS NCs exhibited small particle sizes (~3.3 nm), long photoluminescence lifetimes, and color-tunable properties ranging from the visible to the near-infrared by varying the initial ratio of Cu/In in the precursors.

Ultrasensitive multianalyte electrochemical immunoassay based on metal ion functionalized titanium phosphate nanospheres.

A novel multianalyte electrochemical immunoassay was developed for ultrasensitive detection of human cardiopathy biomarkers cardiac troponin I (cTnI) and human heart-type fatty-acid-binding protein (FABP) using metal ion functionalized titanium phosphate nanospheres (TiP-metal ion) as labels. The metal ions could be detected directly through square wave voltammetry (SWV) without metal preconcentration, and the distinct voltammetric peaks had a close relationship with each sandwich-type immunoreaction. The position and size of the peaks reflected the identity and level of the corresponding antigen.