Publications by authors named "Guo Dongxue"

Purpose: Chemotherapy-induced peripheral neuropathy (CIPN) is a common side effect in patients with breast cancer undergoing chemotherapy. This study aimed to assess the effects of three different intermittent hypothermia temperatures applied to the hands and feet on CIPN symptoms in patients with breast cancer undergoing chemotherapy.

Methods: In total, 108 patients were randomly divided into three experimental groups (n = 36).

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  • - Glabridin, commonly used in cosmetics and pharmaceuticals, is extracted from licorice but can contain harmful impurities, specifically glabrene, which poses significant toxicity risks.
  • - Toxicity tests using zebrafish revealed that glabrene has a lethal concentration (LC) of 2.8 μM, causing severe malformations, disrupted development, reduced mobility, and brain damage in the larvae.
  • - Analysis showed that glabrene triggers abnormal activation of the phenylalanine metabolic pathway, leading to increased levels of dopamine and acetylcholine, highlighting the need for improved safety and quality control in licorice-based products.
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  • Skeletal muscle consists of multinucleated fibers crucial for movement and energy metabolism, while myoblasts are precursor cells essential for muscle fiber development.
  • A breakthrough was made by creating a stable chicken myoblast cell line (termed -myoblasts) using the chicken telomerase reverse transcriptase gene, allowing for extensive growth without cancerous changes.
  • The new cell line demonstrated capabilities for consistent proliferation, differentiation, and transfection, offering valuable resources for studying avian muscle development and primary cell line methodologies.
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The skeletal muscle is the major muscle tissue in animals, and its production is subject to a complex and strict regulation. The proliferation and differentiation of myoblasts are important factors determining chicken muscle development. Circular RNAs (circRNAs) are endogenous RNAs that are widely present in various tissues of organisms.

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Purpose: To investigate the effect of gradient pressure therapy on the prevention of chemotherapy-induced peripheral neuropathy (CIPN) and improvement in activities of daily living (ADL) in patients with breast cancer.

Methods: Eighty female patients with breast cancer treated at Tangshan People's Hospital between October 2022 and July 2023 were selected as research participants and divided into control and intervention, with 40 patients in each group. The control group received routine treatment and care, whereas the intervention group received gradient pressure therapy based on routine treatment and care.

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  • - The study aimed to investigate the impact of compression therapy on chemotherapy-induced peripheral neuropathy (CIPN), anxiety, depression, and sleep disorders in breast cancer patients receiving taxane chemotherapy.
  • - Eighty patients were split into a control group receiving standard care and an intervention group that also received compression therapy during chemotherapy, with assessments made before and after the treatment cycles.
  • - Results showed that after the fourth and sixth cycles, the intervention group had significantly lower levels of CIPN, anxiety, depression, and improved sleep scores compared to the control group, suggesting that compression therapy is beneficial for patients undergoing chemotherapy.
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The quality and quantity of animal meat are closely related to the development of skeletal muscle, which, in turn, is determined by myogenic cells, including myoblasts and skeletal muscle satellite cells (SMSCs). Circular RNA, an endogenous RNA derivative formed through specific reverse splicing in mRNA precursors, has the potential to influence muscle development by binding to miRNAs or regulating gene expression involved in muscular growth at the transcriptional level. Previous high-throughput sequencing of circRNA in chicken liver tissue revealed a circular transcript, circIGF2BP3, derived from the gene encoding insulin-like growth factor 2 mRNA binding protein 3 (IGF2BP3).

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Thermally activated delayed fluorescence (TADF) and hybridized local and charge transfer (HLCT) emitters are two types of highly efficient electroluminescent materials which could improve their internal quantum efficiency (IQE) by converting triplet excitons to singlet ones. However, the molecular designs of TADF and HLCT materials are usually carried out separately because of their distinct emission mechanisms. In this work, we report a rational design strategy for the realization of switching between HLCT and TADF emissions in structurally similar donor-acceptor (D-A) type molecules, which are constructed with the same electron donors (benzo- or naphtho-carbazole) and acceptors with tunable electron-withdrawing abilities (benzonitrile (BN) and benzene-1,2,3,4,5-pentacarbonitrile (BPN)).

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An infinite cell line is one of the most favored experimental tools and plays an irreplaceable role in cell-based biological research. Primary cells from normal animal tissues undergo a limited number of divisions and subcultures before they enter senescence and die. On the contrary, an infinite cell line is a population of non-senescent cells that could proliferate indefinitely under the stimulation of external factors such as physicochemical stimulation, virus infection, or transfer of immortality genes.

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A major issue hindering development of thin film nanocomposite (TFN) nanofiltration (NF) membrane is the interfacial defects induced by nanomaterial aggregation in top layer. Although various nanomaterials surface modification strategies have been developed to eliminate the interfacial defects, they usually involve extra modification steps and complex post-treatments. Inspired by the substrate-independent coating ability of tannic acid (TA) and the fact that the phenolic hydroxyl groups in TA can react with acyl chloride group in trimesoyl chloride, a TA coating solution containing TiO nanoparticles was used as an aqueous phase of interfacial polymerization to prepare interfacial modified TFN NF membranes in this study.

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Nanofiltration (NF) membranes with tannic acid (TA) based selective layers have been intensively studied in recent years, but they still suffer from poor inorganic salt rejection. This study provided a first report on mussel-inspired co-deposition of TA and amine to obtain high-performance NF membranes. The inorganic salt separation performance of the as-prepared NF membrane was significantly improved by optimising the amine molecular weight.

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Inspired by the mussel adhesion mechanism, plant polyphenol tannic acid (TA) with abundant catechol groups and hydrophilic Jeffamine (JA) containing amino groups were used in a layer-by-layer (LBL) process to fabricate composite nanofiltration (NF) membranes in this study. Alternately immersing a polyacrylonitrile substrate into individual TA and JA buffer solutions could readily construct a NF membrane selective layer without any pre-treatment to the substrate. The optimised membrane showed a high pure water permeance of 37 L m h bar whilst maintaining rejections higher than 90% towards various dyes with molecular weights ranging from 269 to 1017 g mol.

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While polyacrylonitrile (PAN) has been widely used to prepare membranes, it is still not handy to prepare PAN integrally skinned asymmetric (ISA) nanofiltration (NF) membrane via direct immersion precipitation phase inversion method. Herein, a low-cost and commercial polyacrylonitrile-co-methylacrylate, P(AN-co-MA), was demonstrated to prepare ISA NF membranes via a one-step immersion precipitation phase inversion process. It was found that increasing P(AN-co-MA) concentration in NMP can shift the membranes from ultrafiltration (UF) to NF range.

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