Interlimb and Intralimb Synergy Modeling for Lower Limb Assistive Devices: Modeling Methods and Feature Selection.

The concept of gait synergy provides novel human-machine interfaces and has been applied to the control of lower limb assistive devices, such as powered prostheses and exoskeletons. Specifically, on the basis of gait synergy, the assistive device can generate/predict the appropriate reference trajectories precisely for the affected or missing parts from the motions of sound parts of the patients. Optimal modeling for gait synergy methods that involves optimal combinations of features (inputs) is required to achieve synergic trajectories that improve human-machine interaction.

Metal-free radical cascade cyclization/haloazidation of enynones to access functionalized 1-indanones.

A novel three-component radical cyclization/haloazidation of enynones, employing TMSN as the azide source and NIS (NBS or NCS) as the halogen source, has been developed under metal-free conditions for the efficient synthesis of various 1-indanones with moderate yields and acceptable / ratio. The reaction progresses through a sequence involving radical addition, 5- cyclization, and radical coupling, ultimately resulting in the formation of three new chemical bonds and a new ring in a single step. The synthetic benefits of this method have been proven by large-scale experiments and late-stage modification.

TRAIP enhances progression of tongue squamous cell carcinoma through EMT and Wnt/β-catenin signaling by interacting with DDX39A.

Background: Tongue squamous cell carcinoma (TSCC) is one of the most common malignant tumors with high mortality and poor prognosis. Its incidence rate is increasing gradually. Tumor necrosis factor receptor-associated factor interacting protein (TRAIP), as a factor related to several tumors, reveals that its gene expression is different between normal tissue and primary tumor of head and neck squamous cell carcinoma using bioinformatics analysis.

A family dynamics theory perspective on parenting styles and children's aggressive behavior.

Background: Children's mental health and behavioral habits are crucial to social development. Previous studies have focused on social learning theory and Baumrind's parenting style theory to explain the impact of parenting style on children's aggressive behavior, but findings have been inconsistent. This paper introduces family dynamics theory in order to further elucidate the complexities surrounding the relationship between parenting styles and child aggression, with the aim of informing interventions to reduce child aggression and promote child behavioral health.

A Comprehensive Evaluation of the HPV Neutralizing Antibodies in Guangzhou, China: A Comparative Study on Various HPV Vaccines.

Background: The evaluation of HPV vaccine effectiveness is essential for informing public health strategies, yet there remains a gap in understanding humoral immune responses generated by different HPV vaccine formulations in regional populations. This study addresses this gap by evaluating the immunogenicity of the newly developed HPV vaccine Cecolin (Wantai), alongside various imported vaccines, including bivalent, quadrivalent, and nonavalent options available in China.

Methods: From March 2023 to June 2024, a total of 352 participants were enrolled, including 87 females aged 9-14 years who received two doses of the bivalent HPV vaccine (Cecolin), 215 females aged 15-45 years who were fully vaccinated with various HPV vaccines, and 50 non-recipients.

The divergent association of diet intake, parental education, and nutrition policy with childhood overweight and obesity from low- to high-income countries: A meta-analysis.

Background: It is unclear whether the effects of dietary intake, parental education, and nutrition policy on childhood overweight and obesity is consistent between high-income (HICs) and low- and middle-income (LMICs) countries. The objective of this meta-analysis was to investigate the association of diet, parental education and nutrition policy with childhood overweight and obesity when the economic levels were controlled.

Methods: PubMed, Web of Science, Embase and Scopus were searched for observational studies published from January 1980 to October 2023 that examined the association of diet, parental education and nutrition policy with childhood overweight and obesity.

Relationships Between Functional Movement Quality and Sports Performance in Elite Figure Skating Athletes of China.

Zhitao, L, Junlong, D, Rui, Y, Leijiao, Y, Cheng, G, and Jun, Y. Relationships between functional movement quality and sports performance in elite figure skating athletes of China. J Strength Cond Res 38(11): e678-e685, 2024-This study aimed to determine the optimal functional movement screen (FMS) cut score for assessing the risk of sports injuries and to explore the correlations between functional movement quality and sports performance among elite figure skaters.

Educational Expectations and Academic Persistence among Rural Adolescents: The Protective Role of High Self-Esteem.

Rural adolescents are at higher risk of reduced academic persistence due to socioeconomic barriers. Educational expectations are theoretically viewed as important for adolescents' learning behaviors, and cross-sectional research has supported this assumption. However, few longitudinal studies have investigated the influence of educational expectations on adolescents' academic persistence.

Enhanced outdoor visual localization using Py-Net voting segmentation approach.

Camera relocalization determines the position and orientation of a camera in a 3D space. Althouh methods based on scene coordinate regression yield highly accurate results in indoor scenes, they exhibit poor performance in outdoor scenarios due to their large scale and increased complexity. A visual localization method, Py-Net, is therefore proposed herein.

Outcome differences of starting Paxlovid for COVID-19 within or after five days of symptoms onset in the elderly: a retrospective study.

Introduction: The study aimed to compare the outcomes of nirmatrelvir and ritonavir drug combination (Paxlovid) therapy in patients who received treatment within or after five days of COVID-19 confirmed in the elderly.

Methodology: This was a single-center, retrospective cohort study of older COVID-19 patients (≥ 60 years) admitted from April 7 to May 30, 2022. Patients were categorized into the EP group (starting Paxlovid within five days) and the LP group (starting Paxlovid after five days) following symptoms onset.

Case Report: A Typical Lyme Disease With Uncommon Neurologic Presentation.

Lyme disease is a very common infectious disease worldwide. The seventh cranial nerve palsy occurred in 9% of Lyme disease cases and the majority of them present as unilateral facial palsy. We present a rare case of bilateral facial palsy in Lyme disease due to infection.

The circulating methylome in childhood-onset inflammatory bowel disease.

The genetic contribution to inflammatory bowel disease (IBD) encompassing both Crohn's disease (CD) and ulcerative colitis (UC), accounts for around 20% of disease variance, highlighting the need to characterise environmental and epigenetic influences. Recently considerable progress has been made in characterising the adult methylome, in epigenome-wide association studies. We report detailed analysis of the circulating methylome in 86 patients with childhood-onset CD,UC and 30 controls using the Illumina Infinium Human MethylationEPIC platform.

Immune cell composition and its impact on prognosis in children with sepsis.

Background: Given the critical role of immune cells and their responses in sepsis pathogenesis, this study aimed to evaluate the prognostic significance of various immune cell ratios in septic children through the collection and analysis of clinical data.

Methods: Clinical data were collected from septic children admitted to the pediatric intensive care unit (PICU) of Shenzhen Children's Hospital between January 2019 and September 2021. The peripheral blood immune cell ratios included the neutrophil to lymphocyte ratio (NLR), the derived neutrophil to lymphocyte ratio (dNLR), the neutrophil to lymphocyte and platelet ratio (NLPR), the monocyte to lymphocyte ratio (MLR), and the platelet to lymphocyte ratio (PLR).

Multipath collaboration-based signal amplification on Z-scheme InO/g-CN heterojunction photoelectrode for sensitive photoelectrochemical immunoassay.

The ideal photoelectrode and efficient signaling strategy are pivotal to achieve sensitive photoelectrochemical (PEC) analysis. Here, a multipath collaborative signal amplification-based PEC immunosensor was constructed for the ultrasensitive detection of cytokeratin 19 fragment 21-1. Specifically, the photoelectrode fabricated by Z-scheme InO/g-CN heterojunction showed enhanced photocurrent intensity in response to visible light.

Personalized Prediction of Long-Term Renal Function Prognosis Following Nephrectomy Using Interpretable Machine Learning Algorithms: Case-Control Study.

Background: Acute kidney injury (AKI) is a common adverse outcome following nephrectomy. The progression from AKI to acute kidney disease (AKD) and subsequently to chronic kidney disease (CKD) remains a concern; yet, the predictive mechanisms for these transitions are not fully understood. Interpretable machine learning (ML) models offer insights into how clinical features influence long-term renal function outcomes after nephrectomy, providing a more precise framework for identifying patients at risk and supporting improved clinical decision-making processes.

Characterization, Phylogenetic Analyses, and Pathogenicity of on Sorghum in China.

Sorghum, the fifth-largest cereal crop globally and a C4 crop, mainly grows in arid and semi-arid areas. In 2021-2023, a new foliar disease of sorghum occurred in China. The diseased leaves showed water-soaked symptoms in the leaf tip and margins, resulting in half- and full-leaf desiccation and necrosis, thus affecting plant photosynthesis.

Associations between parents' adult attachment, Co-parenting and parent-child relationships: an actor-partner interdependence model.

This study used the Actor-Partner Interdependence Model to examine how parents' adult attachment influences their their own and the partners' co-parenting and parent-child relationships. Participants were from a cross-sectional sample of 1313 Chinese heterosexual married couples (fathers' M = 39.74, SD = 5.

The mutual influences between working memory and empathy for pain: the role of social distance.

Understanding the mechanisms behind the interaction of empathy for pain (EfP) and working memory (WM), particularly how they are influenced by social factors like perceived social distance (SD), is vital for comprehending how humans dynamically adapt to the complexities of social life. However, there is very little known about these mechanisms. Accordingly, we recruited 116 healthy participants to investigate the bidirectional influence and electrophysiological responses between WM and EfP, including the role of SD.

A quinine-squaramide catalyzed enantioselective vinylogous Mannich reaction between benzothiazolimines and γ-butenolides for efficient preparation of chiral -benzothiazole butyrolactones.

A highly effective and enantioselective vinylogous Mannich reaction between benzothiazolimines and γ-butenolides catalyzed by a quinine based squaramide has been disclosed. A series of chiral benzothiazole amines containing a γ,γ-disubstituted butanolide scaffold bearing an adjacent chiral stereocenter have been successfully obtained in good to excellent yields (up to 91%) with excellent enantioselectivities (up to >99% ee) and diastereoselectivities (>20 : 1 dr) with broad substrate generality under mild conditions. The new scaffold integrated with both chiral benzothiazolimine and γ-butenolide moieties may provide a possibility for the development of new pharmaceutical entities.

Development of Precision Controllable Magnetic Field-Assisted Platform for Micro Electrical Machining.

In order to introduce the magnetic field into micro electrical machining technology to explore the influence of magnetic field on micro electrical machining, the development of a precision controllable magnetic field-assisted platform is particularly important. This platform needs to precisely control the spatial magnetic field. This study first completes the hardware design and construction of the magnetic field generation device, using electromagnetic coils with soft iron cores as the sources of the magnetic field.