In silico prediction of toxic action mechanisms of phenols for imbalanced data with Random Forest learner.

With an increasing need for the rapid and effective safety assessment of compounds in industrial and civil-use products, in silico toxicity exploration techniques provide an economic way for environmental hazard assessment. The previous in silico researches have developed many quantitative structure-activity relationships models to predict toxicity mechanisms for last decade. Most of these methods benefit from data analysis and machine learning techniques, which rely heavily on the characteristics of data sets.

catena-Poly[[(8-amino-quinoline-κN,N')cadmium]-di-μ-thio-cyanato-κN:S;κS:N-[(8-amino-quinoline-κN,N')cadmium]-di-μ-chlorido].

In the title compound, [CdCl(NCS)(C(9)H(8)N(2))](n), the Cd(II) atom is in a distorted octa-hedral coordination environment defined by two chloride anions, two N atoms from an 8-amino-quinoline ligand, one N atom from one thio-cyanate anion and one S atom from a symmetry-related thio-cyanate anion. Two Cd(II) atoms are bridged by two chloride anions, forming an inversion-related Cd(2)Cl(2) unit; these units are further linked through thio-cyanate anions, leading to a chain structure extending parallel to [010]. Weak π-π stacking inter-actions with centroid-centroid distances of 3.

Chitin-Methacrylate: Preparation, Characterization and Hydrogel Formation.

Chitin-methacrylate (CM) was prepared by the reaction of methacrylic acid on chitin in 5% LiCl/DMAc in the presence of N,N'-dicyclocarbodiimide and dimethylaminopyridine. The resultant chitin-methacrylate product was isolated in 61% yield and was found to be readily water-soluble. The derivative was found to be a mixture of methacrylate and methacrylic-dimethylaminopyridine complex substituents at the C-6 position in approximately equal amounts.

Spontaneous cervical spinal epidural hematoma in the postpartum period.

Study Design: We present the case study of a 31-year-old lady who had a spontaneous cervical spinal epidural hematoma in the postpartum period and who presented with sudden onset of neck pain and lower limb weakness for which an emergency decompressive laminectomy was performed with neurological recovery.

Objective: To report on the spontaneous spinal epidural hematoma in the postpartum period, which is a rare complication during pregnancy and requires early recognition and expedient intervention to prevent permanent neurological sequelae.

Summary Of Background Data: This complication has been described only once previously in the postpartum period.

Erectile dysfunction in young surgically treated patients with lumbar spine disease: a prospective follow-up study.

Study Design: This is a prospective study.

Objective: The prevalence of erectile dysfunction (ED) in patients younger than 50 years with fracture-unrelated lumbar spine disease requiring surgical decompression without other risk factors for ED is evaluated.

Summary Of Background Data: There is little literature documenting ED in young patients with atraumatic lumbar spine disease.

Outer membrane proteome and its regulation networks in response to glucose concentration changes in Escherichia coli.

Escherichia coli growth is a complicated process involved in many factors including the utilization of glucose. It has been reported that E. coli cell growth rate is closely related with glucose concentrations in the cell culture medium.

Functional motor recovery from brain ischemic insult by carbon nanotube-mediated siRNA silencing.

Stroke is the second cause of death worldwide with ischemic stroke accounting for 80% of all stroke insults. Caspase-3 activation contributes to brain tissue loss and downstream biochemical events that lead to programmed cell death after traumatic brain injury. Alleviation of symptoms following ischemic neuronal injury can be potentially achieved by either genetic disruption or pharmacological inhibition of caspases.

An RGD-Modified Endostatin Peptide Expressed at E. coli Shows Anti-Tumor Activity In vivo.

Tumor vasculatures express high levels of α(V)β(3)/α(V)β(5) and α(5)β(1) integrins. Peptide containing the RGD (Arg-Gly-Asp) sequence, which is present in ligands of integrins, is effective in targeting therapeutic reagents to tumor vascular endothelium. In this study, we investigated whether the biological activity of endostatin 27 peptides can be enhanced by the addition of an integrin targeting sequence.

Intermediate Results of the Prestige LP Cervical Disc Replacement: Clinical and Radiological Analysis With Minimum Two-Year Follow-up.

Study Design: prospective study.

Objective: present results of Prestige LP artificial cervical disc replacement (ADR).

Summary Of Background Data: motion preservation with ADR can potentially reduce adjacent segment degeneration.

Hybrid polymer-grafted multiwalled carbon nanotubes for in vitro gene delivery.

Carbon nanotubes (CNTs) consist of carbon atoms arranged in sheets of graphene rolled up into cylindrical shapes. This class of nanomaterials has attracted attention because of their extraordinary properties, such as high electrical and thermal conductivity. In addition, development in CNT functionalization chemistry has led to an enhanced dispersibility in aqueous physiological media which indeed broadens the spectrum for their potential biological applications including gene delivery.

Enhanced anticancer activity of multi-walled carbon nanotube-methotrexate conjugates using cleavable linkers.

Methotrexate was tethered to multi-walled carbon nanotubes through different cleavable linkers exploiting the ammonium functionalities introduced by 1,3-dipolar cycloaddition reaction of azomethine ylides to the nanotubes. The new nanobio-hybrid conjugates were internalized into human breast cancer cells and it was shown that the cytotoxic activity was strongly dependent on the presence and type of linker.

Matrix metalloproteinase 1 is necessary for the migration of human bone marrow-derived mesenchymal stem cells toward human glioma.

Human mesenchymal stem cells (MSCs) have increasingly been used as cellular vectors for the delivery of therapeutic genes to tumors. However, the precise mechanism of mobilization remains poorly defined. In this study, MSCs that expressed similar cell surface markers and exhibited multilineage differentiation potentials were isolated from various donors.

[Bovine serum albumin in the presence of zinc (II) by fluorescence method].

The interaction between norfloxacin and bovine serum albumin, and the influence of Zinc (II) on the system of norfloxacin and bovine serum albumin was studied under physiological condition by fluorescence method. It was shown that norfloxacin has a powerful ability to quench the BSA fluorescence via a nonradiative energy transfer mechanism. The fluorescence quenching data were analyzed according to Stern-Volmer equation and double-reciprocal equation, and the binding constant (K) and the binding sites (n) were obtained.

Deoxycholyltaurine rescues human colon cancer cells from apoptosis by activating EGFR-dependent PI3K/Akt signaling.

Recent studies indicate that secondary bile acids promote colon cancer cell proliferation but their role in maintaining cell survival has not been explored. We found that deoxycholyltaurine (DCT) markedly attenuated both unstimulated and TNF-alpha-stimulated programmed cell death in colon cancer cells by a phosphatidylinositol 3-kinase (PI3K)-dependent mechanism. To examine the role of bile acids and PI3K signaling in maintaining colon cancer cell survival, we explored the role of signaling downstream of bile acid-induced activation of the epidermal growth factor receptor (EGFR) in regulating both apoptosis and proliferation of HT-29 and H508 human colon cancer cells.

Selective inhibition of inducible NO synthase activity in vivo reverses inflammatory abnormalities in surfactant protein D-deficient mice.

Surfactant protein D (SP-D)-deficient (SP-D-/-) mice exhibit early development of emphysema. Previously we have shown that SP-D deficiency results in increased production and activity of inducible NO synthase (iNOS). In this study, we examined whether treatment with the iNOS inhibitor 1400W could inhibit the inflammatory phenotype.

Evidence for functional P2X4/P2X7 heteromeric receptors.

The cytolytic ionotropic ATP receptor P2X7 has several important roles in immune cell regulation, such as cytokine release, apoptosis, and microbial killing. Although P2X7 receptors are frequently coexpressed with another subtype of P2X receptor, P2X4, they are believed not to form heteromeric assemblies but to function only as homomers. Both receptors play a role in neuropathic pain; therefore, understanding how they coordinate the cellular response to ATP is important for the development of effective pain therapies.

Results, experience and technical points learnt with use of the SKy Bone Expander kyphoplasty system for osteoporotic vertebral compression fractures: a prospective study of 40 patients with a minimum of 12 months of follow-up.

To describe our centre's results, experience and technical points learnt with the SKy Bone Expander System for osteoporotic vertebral compression fractures (VCFs). Forty consecutive patients with painful single level T12 or L1 osteoporotic VCF who had failed conservative management for more than 3 months had 40 single level SKy Bone Expander kyphoplasties performed. Using local anaesthesia with patients in a prone, hyper-lordotic position, a unilateral, percutaneous, intra-pedicular approach was employed.

[Study on the ternary complex of FLRX, zinc(II) and BSA by the method of fluorescence].

The influences of fleroxacin (FLRX) on the fluorescence of bovine serum albumin(BSA), zinc(II) on that of bovine serum albumin, and zinc(II) on the of fleroxacin and bovine serum albumin were studied under imitated the physiological condition. It was shown that both fleroxacin and zinc(II) have a powerful ability to quench the BSA fluorescence via a nonradiative energy transfer mechanism. But the fluorescence quenching action of fleroxacin on BSA was much stronger in the presence of zinc (II).

Facile synthesis of water-soluble and size-homogeneous cadmium selenide nanoparticles and their application as a long-wavelength fluorescent probe for detection of Hg(II) in aqueous solution.

Highly luminescent uncoated water-soluble and mono-disperse CdSe nanoparticles (NPs) have been prepared facilely. Uncoated CdSe core NPs possessing a good size distribution was accompanied with long wavelength of fluorescence emission. It is interesting to note that these functionalized NPs are soluble in water medium stably for more than 1 month, and no significant changes were found in the optical characteristics in comparison with fresh CdSe NPs prepared.

Implementing a personalized portal combined with workflow management tools used in diabetes care.

Diabetes care is one of the most important medical care works in nowadays. However, the dispersal of current diabetes medical practice leads to an uncoordinated work flow. Lacking of personal health information makes patients hard to implement self-care and medical providers have to deal with lots of paperwork.