Synthesis of ximelagatran, melagatran, hydroxymelagatran, and ethylmelagatran in H-3 labeled form.

In support of a study designed to better understand the liver toxicity of ximelagatran, ximelagatran, and melagatran, hydroxymelagatran and ethylmelagatran were prepared in tritium labeled form. Incorporation of tritium was achieved by hydrogen isotope exchange using Crabtree's catalyst and later with N-heterocyclic containing Ir catalyst. The tritiated product was then converted into the four target compounds to afford them in high purity and specific activity.

Erucamide as a modulator of water balance: new function of a fatty acid amide.

The aim of this study was to isolate a compound from blood plasma that inhibits intestinal diarrhea and that appears also to regulate fluid volumes in other organs. The isolation procedure included lipid extraction, liquid chromatography, and gas chromatography. The active substance was identified by mass spectrometry as erucamide (MW 337 Da).

Synthesis, Structure, and Photophysical Properties of Novel Ruthenium(II) Carboxypyridine Type Complexes.

A series of Ru(II) compounds and salts have been synthesized: [Ru(6-carboxylato-bpy)(2)] (5), [Ru(6-carboxylato-bpy)(tpy)]PF(6) (9), [Ru(tpy)(2)](PF(6))(2) (8), and [Ru(bpy)(2)(Pic)]PF(6) (11), where 6-carboxy-bpy (1) = 6-carboxy-2,2'-bipyridine, tpy (2) = 2,2':6',2"-terpyridine, and Pic = 2-carboxylatopyridine. The compounds have been characterized by NMR, electrospray mass spectrometry (ESI-MS), cyclic voltammetry, absorption and emission spectroscopy (at 100, 140, and 298 K), and single-crystal X-ray diffraction (complex 5). Complex 5 crystallizes in the monoclinic system, space group P2(1)/n, formula RuC(22)H(14)N(4)O(4).