Sequence variation at ANAPC1 accounts for 24% of the variability in corneal endothelial cell density.

The corneal endothelium is vital for transparency and proper hydration of the cornea. Here, we conduct a genome-wide association study of corneal endothelial cell density (cells/mm), coefficient of cell size variation (CV), percentage of hexagonal cells (HEX) and central corneal thickness (CCT) in 6,125 Icelanders and find associations at 10 loci, including 7 novel. We assess the effects of these variants on various ocular biomechanics such as corneal hysteresis (CH), as well as eye diseases such as glaucoma and corneal dystrophies.

[Demodex folliculorum a hidden cause of blepharitis].

Unlabelled: Meibomian gland dysfunction (MGD) is a common cause of dry eye disease. Demodex mites can cause MGD with symptoms like itching, dryness and general ocular discomfort. It is important to consider infestation with Demodex mites in individuals who are non responsive to traditional MGD treatment but also equally important when cylindrical dandruff is seen at the base of the eye lashes.

The 7-year cumulative incidence of cornea guttata and morphological changes in the corneal endothelium in the Reykjavik Eye Study.

Purpose: To examine the corneal endothelium and establish the 7-year cumulative incidence of cornea guttata (CG).

Methods: Population-based prospective cohort study with 573 participants (third wave of the Reykjavik Eye Study (RES) in 2008). Four hundred and thirty-seven subjects had either right or left eyes available for analysis after excluding confounding eye conditions.

Automatic retinal oximetry.

Purpose: To measure hemoglobin oxygen saturation (SO(2)) in retinal vessels and to test the reproducibility and sensitivity of an automatic spectrophotometric oximeter.

Methods: Specialized software automatically identifies the retinal blood vessels on fundus images, which are obtained with four different wavelengths of light. The software calculates optical density ratios (ODRs) for each vessel.

[Chemical injuries of the eye - management of alkali burns.].

Chemical injuries are among the most severe injuries to the eye. Young men are most often affected. Work related injuries are more common than other types of injuries.

[Angiomatosis retinae. Case report.].

Angiomatis retinae is diagnosed in a diabetic woman on routine diabetic retinopathy screening.

Prevalence and risk factors for cornea guttata in the Reykjavik Eye Study.

Purpose: To establish the age- and gender-specific prevalence of cornea guttata (CG) in citizens of Reykjavik, Iceland, 55 years and older.

Design: Cross-sectional, random, population-based study.

Participants: The 774 participants were those participating in the second examination of the Reykjavik Eye Study.

Screening compliance and visual outcome in diabetes.

Purpose: To study the relationship between screening compliance and visual outcome in a screening programme for diabetic eye disease.

Methods: A retrospective case control study. The screening compliance of all the diabetes patients (n = 22) listed at the Icelandic National Registry for the Blind (visual acuity <0.