Supportive evidence for 11 loci from genome-wide association studies in Parkinson's disease.

Genome-wide association studies have identified a number of susceptibility loci in sporadic Parkinson's disease (PD). Recent larger studies and meta-analyses have greatly expanded the list of proposed association signals. We performed a case-control replication study in a Scandinavian population, analyzing samples from 1345 unrelated PD patients and 1225 control subjects collected by collaborating centers in Norway and Sweden.

[Multifocal motor neuropathy--unusual cause of hypoglossal palsy].

Multifocal motor neuropathy with conduction block (MMN-CB) very rarely presents with cranial nerve symptoms. We describe a 72-year old man who was referred for a neurological evaluation because of a one-year long history of right-sided hypoglossal palsy with fasciculations. Since the examination also revealed slight atrophy in the hands, a motor neuron disease (MND) was suspected.