Effect of calcium supplementation on reversing metformin-based inhibition of vitamin B bioavailability in healthy adults using a [C] cyanocobalamin tracer - A pilot study.

Background & Aims: Metformin is a widely prescribed first line drug for the treatment of type 2 diabetes mellitus (DM). Studies have shown that the use of metformin is often associated with a decrease in vitamin B (B) levels in patients with DM. Few studies have shown that this effect could be mitigated with calcium supplementation.