Emissive Features of Perylene Diimide Derivative with β-Cyclodextrin: Probing the role of inter and intramolecular interactions.

Perylene diimide (PDI) derivatives have been extensively explored as chromophoric dyes for functional organic materials. Here, the custom synthesized tyrosine appended perylene diimide (PDI-Tyr) derivative has shown strong aggregation in aqueous medium diminishing its emissive features, which was surpassed by the supramolecular interaction with β-cyclodextrin (β-CD). Complex formation between PDI-Tyr and β-CD, proposed from the absorption and emission studies, have been substantiated by the H-NMR, ITC and geometry optimization data.

Building risk mitigation strategies for circularity adoption in Indian textile supply chains.

Textile industries are among the most polluting and demand urgent management measures to mitigate their negative environmental impact. Thus, it is imperative to incorporate the textile industry into the circular economy and to foster sustainable practices. This study aims to establish a comprehensive, compliant decision framework to analyse risk mitigation strategies for circular supply chain (CSC) adoption in India's textile industries.

Role of Average Volume Assured Pressure Support Mode (AVAPS) in the Management of Acute Exacerbation of Chronic Obstructive Pulmonary Disease With Type 2 Respiratory Failure.

Background Non-invasive ventilation (NIV) is a well-established approach in the treatment of acute exacerbation of chronic obstructive pulmonary disease (COPD) with type 2 respiratory failure. Average volume-assured pressure support (AVAPS) mode integrates the characteristics of both volume and pressure-controlled modes of NIV. In bilevel positive airway pressure (BiPAP) mode, volume is the dependent variable, whereas in AVAPS mode, pressure is the dependent variable.

COVID19 epidemic outbreak: operating rooms scheduling, specialty teams timetabling and emergency patients' assignment using the robust optimization approach.

The health care system is characterized by limited resources, including the physical facilities as well as skilled human resources. Due to the extensive fixed cost of medical facilities and the high specialization required by the medical staff, the problem of resource scarcity in a health care supply chain is much more acute than in other industries. In the pandemic of the Coronavirus, where medical services are the most important services in communities, and protective and preventive guidelines impose new restrictions on the system, the issue of resource allocation will be more complicated and significantly affect the efficiency of health care systems.

Global food security post COVID-19: Dearth or dwell in the developing world?

Today, global food systems are highly susceptible to food safety risks, economic shocks, price volatility, and natural disasters and pandemics, such as the novel coronavirus (COVID-19). This paper draws from research on food and nutritional security, food fraud and associated economic ecosystem, and the disruptions due to COVID-19 for socio-economic inequality globally. It is concluded that the safety risks have pushed enforcement of measures to reduce food supplies, adversely impacting food availability.

9th GCC closed forum: CAPA in regulated bioanalysis; method robustness, biosimilars, preclinical method validation, endogenous biomarkers, whole blood stability, regulatory audit experiences and electronic laboratory notebooks.

The 9th GCCClosed Forum was held just prior to the 2015 Workshop on Recent Issues in Bioanalysis (WRIB) in Miami, FL, USA on 13 April 2015. In attendance were 58 senior-level participants, from eight countries, representing 38 CRO companies offering bioanalytical services. The objective of this meeting was for CRO bioanalytical representatives to meet and discuss scientific and regulatory issues specific to bioanalysis.

Challenges in application of bioanalytical method on different populations and effect of population on PK.

Prashant Kale has 22 years of immense experience in the analytical and bioanalytical domain. He is Senior Vice President, Bioequivalence Operations of Lambda Therapeutic Research, India which includes Bioanalytical, Clinics, Clinical data management, Pharmacokinetics and Biostatistics, Protocol writing, Clinical lab and Quality Assurance departments. He has been with Lambda for over 14 years.

Determination of mycophenolic acid in human plasma by high-performance liquid chromatography.

The development, validation and evaluation of high-performance liquid chromatography (HPLC) method for quantifying mycophenolic acid in human plasma is described. The method involved protein precipitation using acetonitrile, after addition of terazosin as an internal standard. Separation was achieved with a reversed-phase C18 column (250 mm x 4.