Publications by authors named "Gunel Maharramova"
In this study, compounds with 4-hydroxybutyl, 4-phenyl, 5-carboxylate, and pyrimidine moieties were determined as α-glycosidase inhibitors. N-Substituted pyrimidinethione and acetophenone derivatives (A1-A5, B1-B11, and C1-C11) were good inhibitors of the α-glycosidase enzyme, with K values in the range of 104.27 ± 15.
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- A new synthetic method using trifluoroacetic acid allows the creation of a specific compound involving phenylthiourea, salicylaldehyde, and methyl-3-oxobutanoate.
- The resulting N-substituted tetrahydropyrimidines are found to effectively inhibit key enzymes including acetylcholinesterase and human carbonic anhydrase isoforms, with low inhibition values indicating strong potency.
- Additionally, these compounds have been shown to possess significant antioxidant activity, evaluated through various in vitro assays.