Publications by authors named "Gundugurti Prasad Rao"
Background: Anxiety disorders, an increasingly prevalent global mental health illness, affected approximately 301 million individuals worldwide in 2019. There is an unmet need for the treatment of anxiety disorders, as current therapies are associated with limited response rates, residual symptoms, and adverse effects.
Objectives: To evaluate the efficacy, safety, and pharmacokinetics of nanodispersible cannabidiol (CBD) oral solution versus placebo for the treatment of mild to moderate anxiety disorders.
Article Synopsis
- The study explores copy number variants (CNVs) as significant genetic factors in schizophrenia, focusing on a South Indian population for the first time.
- Researchers identified 63 different CNVs in 168 schizophrenia patients and 168 controls, noting a higher presence of medium-sized deletions in patients compared to controls.
- The findings underscore the need for further research in larger samples and suggest that an integrated approach can enhance the identification of CNVs linked to schizophrenia and other mental health disorders.
Article Synopsis
- A genome-wide association study (GWAS) in an Indian population identified novel genetic loci associated with schizophrenia, contributing to the understanding of the disorder beyond findings from European populations.
- The study involved 3,092 participants, including individuals with schizophrenia, their family members, and unrelated controls, using rigorous diagnostic criteria and recruitment methods from various medical facilities in Chennai.
- A significant association was found with a specific locus on chromosome 8q24.3, showing a potential risk allele that declined in frequency, suggesting natural selection influences on its prevalence in the Indian population.
Copy number variants (CNVs) of 15q11.2 yielded conflicting reports on their association with schizophrenia (SZ), indicating the need for replication studies. Because there are no 15q11.
View Article and Find Full Text PDFBackground: There is increasing recognition of cardiovascular mortality and comorbidity in bipolar disorder (BD) in the recent times. Framingham 10 years risk of coronary heart disease (CHD) has been a widely accepted as a reliable estimate of cardiovascular risk in the general population. A few studies have estimated the relative risk of developing CHD in BDs, in India.
View Article and Find Full Text PDFBackground: Schizophrenia is associated with functional challenges for patients; relapses in schizophrenia may lead to increased treatment costs and poor quality of life.
Objective: This SUSTAIN-I study was conducted to establish psychiatrists' perspective on impact of long-acting injectables (LAIs) antipsychotics on the socio-economic and functional burden of schizophrenia.
Methods: This cross-sectional, survey-based study was conducted in 5 cities in India.
India ratified the United Nations Convention on the Rights of Person with Disabilities (UNCRPD) in 2007. This is a welcome step towards realizing the rights of the persons with disability. The UNCRPD proclaims that disability results from interaction of impairments with attitudinal and environmental barriers which hinders full and active participation in society on an equal basis with others.
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