Publications by authors named "Gundapaneni Kishore Kumar"
Genotypic and haplotype analysis of Interleukin-6 and -18 gene polymorphisms in association with clinicopathological factors in breast cancer.
Cytokine
December 2022
Cytokines are multifunctional glycoproteins that play a vital role in the tumor microenvironment and progression of breast cancer. Genetic polymorphisms may influence the immune responses restrained by pro- and anti-inflammatory cytokine expression in tumors. Hence, the present study evaluated the contribution of Interleukin (IL) 6 (rs1800797, rs1800796, and rs1800795) and IL18 (rs1946518, rs187238, and rs549908) genotypes and their haplotypes to the risk, progression of breast cancer in South Indian population.
View Article and Find Full Text PDFIntroduction: Proprotein convertase subtilisin/kexin type 9 (PCSK9) genetic polymorphisms play a significant role in cholesterol homeostasis. Therefore, we aimed to investigate the association of PCSK9 genetic variations NM_174936.3:c.
View Article and Find Full Text PDFCollagenase-1 (-1607 1G/2G), Gelatinase-A (-1306 C/T), Stromelysin-1 (-1171 5A/6A) functional promoter polymorphisms in risk prediction of type 2 diabetic nephropathy.
Gene
October 2018
Type 2 Diabetic Nephropathy (DN) is a common multifactorial disorder. Degradation of glomerular basement membrane (GBM) by matrix metalloproteases (MMPs) is a key event in the progression of renal disease. A functional polymorphism at position -1607 1G/2G, -1306 C/T and -1171 5A/6A has been shown to alter the transcriptional activity of MMP-1, MMP-2, and MMP-3 respectively, and also associated with several diseases contributing to inter-individual differences in susceptibility to type 2 DN.
View Article and Find Full Text PDFSynergistic effect of collagenase-1 (MMP1), stromelysin-1 (MMP3) and gelatinase-B (MMP9) gene polymorphisms in breast cancer.
PLoS One
November 2017
Article Synopsis
- * Researchers genotyped specific SNPs in 300 breast cancer patients and 300 healthy controls, utilizing various statistical software for analysis to find significant associations between certain alleles and increased breast cancer susceptibility.
- * Findings indicated that specific MMP polymorphisms are associated with clinical characteristics like hormone receptor status and metastasis, suggesting that these genetic variations collectively increase breast cancer risk and may influence patient survival.
Article Synopsis
- * The study analyzes polymorphisms in CASP8 and CASP3 genes among 300 CAD patients and 300 healthy controls, using genetic testing methods to identify variations linked to disease risk.
- * Findings indicate that certain genotypes of CASP8 and CASP3 are associated with an increased risk of CAD, suggesting these polymorphisms could serve as genetic markers for the disease.
Genetic polymorphisms of eNOS (-786T/C, Intron 4b/4a & 894G/T) and its association with asymptomatic first degree relatives of coronary heart disease patients.
Nitric Oxide
November 2016
Article Synopsis
- - The study investigates the genetic variations of the eNOS gene (specifically the -786T/C, Intron 4b/4a, and 894G/T polymorphisms) and their link to the higher prevalence of Coronary Heart Disease (CHD) among young Indians and their first-degree relatives (FDRS).
- - Results reveal that FDRS and CHD patients exhibit significantly higher risk factors (like obesity and family history) compared to healthy controls, alongside notable differences in eNOS genotype frequencies.
- - The findings highlight the critical role of eNOS variations in CHD development and suggest potential for predicting coronary risks and developing preventative treatments for at-risk individuals.
Coronary artery disease (CAD) remains to be the prominent health problem in India, and its incidence is growing in developing countries as well. Matrix metalloproteinase 1 (MMP 1) is highly expressed in disruption-prone shoulder regions of the fibrous plaques. The present study aims to investigate association of MMP 1 gene polymorphisms (-1607 1G/2G) and serum circulating levels with CAD.
View Article and Find Full Text PDFArticle Synopsis
- Coronary Artery Disease (CAD) is a major global health issue caused by the buildup of lipid-rich plaques in the arteries, and atorvastatin is a commonly used statin for managing cholesterol levels and reducing cardiovascular risks.
- * The study aimed to assess the effectiveness of atorvastatin on lipid profiles and DNA damage in CAD patients by comparing results before and after 6 months of treatment with a control group.
- * Results showed that atorvastatin significantly improved lipid profiles and reduced DNA damage in CAD patients, suggesting potential benefits in disease management.