Understanding Neural Factors in Burn-related Pruritus and Neuropathic Pain.

Post-burn pruritus and neuropathic pain significantly affect the quality of life of affected individuals in several domains including psychosocial well-being, sleep and general impairment in activities of daily living. Whilst neural mediators involved in itch in the non-burns setting have been well investigated, there remains a lacuna of literature examining the pathophysiological and histological changes unique to burn-related pruritus and neuropathic pain. The aim of our study was to conduct a scoping review into the neural factors that contribute to burn-related pruritus and neuropathic pain.

A Rapid and Satisfactory Outcome with Combined Immunosuppressive Therapy in Acquired Haemophilia A with Underlying Tuberculosis.

Acquired haemophilia A (AHA) is a rare disorder with an incidence of 1.5 cases per million per year in the United Kingdom. The incidence could be underestimated due to difficulty in diagnosis and also due to the fact that people with low titre inhibitor levels are asymptomatic.

Polymeric fiber sensors for insertion forces and trajectory determination of cochlear implants in hearing preservation.

The level of hearing restoration in patients with severe to profound sensorineural hearing loss by means of cochlear implants (CIs) has drastically risen since the introduction of these neuroprosthetics. The proposed CI integrated with polymer optical fiber Bragg gratings (POFBGs) enables real-time evaluation of insertion forces and trajectory determination during implantation irrespective of the speed of insertion, as well as provides high signal quality, low stiffness levels, minimum induced stress even under forces of high magnitudes and exhibits significant reduction of the risk of fiber breakage inside the constricted cochlear geometry. As such, the proposed device opens new avenues towards atraumatic cochlear implantations and provides a direct route for the next generation of CIs with intraoperative insertion force assessment and path planning capacity crucial for surgical navigation.

Cryptocaryoic acids A - C: New phenyl alkyl acids isolated from the leaves of Australian rainforest plant Cryptocarya mackinnoniana.

Phytochemical investigation of the leaves of the Australian rainforest tree Cryptocarya mackinnoniana led to the discovery of three new oxygenated phenyl alkyl acids, cryptocaryoic acids A - C and two known compounds, cryptocaryone and 2',6'-dihydroxy-4'-methoxychalcone. The structures of all the compounds were determined by detailed spectroscopic analysis. Mosher's analysis was used for absolute stereochemistry determination at C-11, while the remaining stereochemistry determination of the one remaining stereocenter C-13 was based on NOESY correlations.

Modified Giemsa Stain: A solution to improve the quality of hypercellular bone marrow smears.

Introduction: Morphology is still the cornerstone of the diagnosis of haematological malignancies where the quality of staining plays a major role. The hypercellularity of a smear interferes with the quality of staining. We compared a newly modified giemsa stain (MGS) as a routine method for staining hypercellular bone marrow smears over the conventional Leishman method and the May Grunwald Giemsa method (MGG) in a completely randomized block study.

Hepatic metastasis of anal squamous cell carcinoma.

A 50-year-old woman was diagnosed with anal squamous cell carcinoma following a colonoscopy performed for positive test from the National Bowel Screening Programme. During the staging imaging, it was discovered to have a liver lesion that was atypical for metastasis. She underwent a segmental liver resection, and histopathology showed the liver lesion as a metastatic squamous cell carcinoma.

Implant deformity on screening mammography, an unusual presentation of breast implant associated lymphoma.

Breast implant associated anaplastic large cell lymphoma (BIA-ALCL) is a rare condition related to textured breast implants. Recognition of characteristic imaging and pathological features are important, given the absence of symptoms can delay diagnosis, as illustrated by this case. Late-onset peri-implant effusion is commonly encountered whilst an associated mass or lymphadenopathy are rare.

Constitutive Cytomorphologic Features of Medullary Thyroid Carcinoma Using Different Staining Methods.

(1) Background: Accurate preoperative identification of medullary thyroid carcinoma (MTC) is challenging due to a spectrum of cytomorphologic features. However, there is a scarcity of studies describing the cytomorphologic features as seen on fine-needle aspiration (FNA) smears prepared using different staining methods. (2) Methods: We performed a retrospective study on MTC cases with available FNA slides from 13 hospitals distributed across 8 Asia-Pacific countries.

Tracheostomy in free-flap reconstruction of the oral cavity: can it be avoided? A cohort study of 187 patients.

Background: Head and neck surgeons are moving away from routine tracheostomy in free-flap reconstruction. We reviewed prophylactic tracheostomy use in patients undergoing oral cavity or oropharynx free-flap reconstruction to identify patient groups who avoided tracheostomy. Secondary aims were to describe complications associated with and without tracheostomy.

Two semicircular-hole fiber in a Sagnac loop for simultaneous discrimination of torsion, strain and temperature.

We report a highly sensitive twist sensor based on a Sagnac interferometer constructed with a new type of optical fiber which contains an elliptical core and two large semicircular-holes, where the slow axis of the core orthogonal to the air-holes has a large sensitivity towards twist-induced birefringent changes. The novel fiber structure results in a highest twist sensitivity of 5.01 nm/° at a chosen dip over the range from 370°-400°.

The significance of histological activity measurements in immune checkpoint inhibitor colitis.

Background: Colitis is a significant complication of immune checkpoint inhibitors (ICI). Currently, clinical and endoscopic severity are used to guide therapy.

Aims: To investigate associations between clinical, endoscopic, and histological features with outcomes METHODS: We identified 149 patients from seven institutions with biopsy-proven ICI colitis.

Single nanosecond-pulse production of polymeric fiber Bragg gratings for biomedical applications.

In this study, we present first-time fabrication of FBGs in all ZEONEX-based SMPOFs with a single 25 ns pulse of 248 nm UV irradiation over a 12-month period, which opens up new frontiers in optics and photonics for the effective fabrication of polymer optical fiber Bragg gratings (POFBGs), permitting mass producibility of them. POFBGs were characterized by subjecting them to various physical parameters including temperature and tensile strain. Strain responses of FBGs with similar grating strengths fabricated with 248 nm and 325 nm He-Cd laser irradiations were explored over a year to demonstrate their long-term stability and applicability.

Silicone Rubber Based Highly Sensitive Fiber-Optic Fabry-Perot Interferometric Gas Pressure Sensor.

A simple, compact, and highly sensitive gas pressure sensor based on a Fabry-Perot interferometer (FPI) with a silicone rubber (SR) diaphragm is demonstrated. The SR diaphragm is fabricated on the tip of a silica tube using capillary action followed by spin coating. This process ensures uniformity of its inner surface along with reproducibility.

Cytologic diagnosis of medullary thyroid carcinoma in the Asia-Pacific region.

Background: The accurate preoperative identification of medullary thyroid carcinoma (MTC) is challenging due to the rarity of tumor and variable cytologic appearance. The Asian experience with diagnosing MTC by fine-needle aspiration (FNA) was scarcely reported.

Methods: Cases of MTC with available FNA slides were enrolled from 13 hospitals representing 8 Asia-Pacific countries.

Mulgravanols A and B, rare oxidized xanthenes and a new phloroglucinol isolated from the Australian rainforest plant Waterhousea mulgraveana (Myrtaceae).

Phytochemical investigation of the Australian rainforest plant leaves Waterhousia mulgraveana, yielded two rare oxidized xanthenes, mulgravanols A (1) and B (2) along with a new phloroglucinol, mulgravanol C (3). Mulgravanol A (1) is the first reported example of a complex xanthene flanked by a methine bridged phloroglucinol unit. All the compounds displayed moderate inhibitory effects on nitric oxide production and TNF-α release in RAW 264.

Microstructured optical fiber based Fabry-Pérot interferometer as a humidity sensor utilizing chitosan polymeric matrix for breath monitoring.

This study reports a method for humidity sensing based on a specialty microstructured optical fiber (MOF). A suspended tri-core MOF was fabricated using the stack and draw technique. A low finesse sensing head was prepared by depositing a chitosan polymer matrix within the holes of the MOF, forming a Fabry-Pérot interferometer as a sensing platform while the chitosan film acts as the sensing material.

Resurgent regenerated fiber Bragg gratings and thermal annealing techniques for ultra-high temperature sensing beyond 1400°C.

We report for the first time the resurgence of regenerated fiber Bragg gratings (RFBGs) useful for ultra-high temperature measurements exceeding 1400 °C. A detailed study of the dynamics associated with grating regeneration in six-hole microstructured optical fibers (SHMOFs) and single mode fibers (SMFs) was conducted. Rapid heating and rapid cooling techniques appeared to have a significant impact on the thermal sustainability of the RFBGs in both types of optical fibers reaching temperature regimes exceeding 1400 °C.

Integrated Force Sensor in a Cochlear Implant for Hearing Preservation Surgery.

Cochlear Implant is used for patients with severe hearing loss. It is a neural-prosthesis that stimulates the nerve endings within the cochlea, which is the organ of hearing. The surgical technique involves inserting the electrode array of the implant into a very small "snail-like" spiral structure.

Non-mass versus mass-like ultrasound patterns in ductal carcinoma in situ: is there an association with high-risk histology?

Aim: To review the ultrasound (US) patterns of pure ductal carcinoma in situ (DCIS) using a non-mass-like (NML) versus mass-like (ML) classification and to investigate histopathological associations.

Materials And Methods: The present study was a retrospective analysis of sonographically evident pure DCIS lesions detected in a mammographic (MG) screening programme over a 7-year period from 2008. All lesions had undergone US-guided 14 G core biopsies with no upgrades to invasive disease on surgical histopathology.

Novel accelerometer realized by a polarization-maintaining photonic crystal fiber for railway monitoring applications.

In this paper, we present a novel accelerometer based on the Sagnac interferometer configuration using a polarization-maintaining photonic crystal fiber (PM-PCF), which has a sensitivity of ~8 pm/G, and a resonant frequency exceeding 2.5 kHz. The proposed accelerometer is capable of functioning with a constant sensitivity in a large frequency range from 0 to 1 kHz which is much wider than many FBG-based accelerometers.

Two-dimensional vector accelerometer based on Bragg gratings inscribed in a multi-core fiber.

We propose and demonstrate a novel orientation-sensitive two-dimensional accelerometer based on fiber Bragg gratings inscribed in a multi-core fiber. Through monitoring of the wavelength shifts of three of the seven cores, including the central core and two outer cores which are not aligned in a straight line, information on vibration orientation as well as acceleration can be obtained simultaneously. Performance of the proposed accelerometer in terms of frequency, acceleration and vibration orientation are experimentally investigated.

Fabry-Perot cavity-based contact force sensor with high precision and a broad operational range.

A novel, compact, and robust contact force sensor based on a micro-length single-mode fiber (SMF) incorporated in a cleaved micro-air cavity (MAC) is proposed. The fabrication process involves splicing of the SMF with a hollow-core fiber (HCF) followed by cleaving of the MAC and insertion of a SMF into the MAC. The force sensing mechanism is based on the movement of the micro-SMF inside the cleaved MAC.