Publications by authors named "Gunasekaran Venkatesh"
C-Glucosyl Xanthone derivative Mangiferin downregulates the JNK3 mediated caspase activation in Almal induced neurotoxicity in differentiated SHSY-5Y neuroblastoma cells.
Toxicol Mech Methods
November 2023
Introduction: C-Glucosyl Xanthone derivatives were assessed to inhibit the JNK3 mediated Caspase pathway in Almal (Aluminum Maltolate) induced neurotoxicity in SHSY-5Y cells.
Methods: Mangiferin was selected among 200 C-Glucosyl Xanthones based on molecular interaction, docking score (-10.22 kcal/mol), binding free energy (-71.
Article Synopsis
- - The study developed a self-nanoemulsifying drug delivery system (SNEDDS) using aqueous leaf extracts of two plants, JA and PG, to boost platelet counts and tested its effectiveness in Wistar rats.
- - A ternary phase diagram helped identify suitable self-emulsifying components, with the optimized SNEDDS showing specific globule sizes, indicating stability across different pH levels without phase separation.
- - Results indicated that the combined SNEDDS formulation notably increased platelet counts in treated rats compared to a standard drug, Caripill, demonstrating its potential as a therapeutic option for platelet deficiencies.
Pentacyclic Phytomolecule 3-O-Acetyl-11-keto-β-boswellic acid (AKBA) from Frankincense family has proven for the neuroprotection and recognized as an orphan drug for the treatment of cerebral edema. Nonetheless, AKBA have promising indications with Peroxisome proliferator activated receptor gamma (PPARγ) associated to cognitive function not deliberated so far. In order to substantiate the potential role of AKBA on memory function, we examine the contribution of PPARγ activation and its downstream process.
View Article and Find Full Text PDFOvert expression of brain glucocorticoid receptor (GR) leads to elevation of glutamate release causes cerebral excitotoxicity which in turn produce neuropsychological disorders. The aim of our work is to study the consequence of 3-O-Acetyl-11-keto-β-boswellic acid (AKBA) on chronic unpredictable mild stress (CUMS) induced HPA axis dysregulation in relative to glutamate and GABA irregularity in depressive rats. AKBA (5, 10 &15mg/kg) was administered for 28 days parallel with CUMS induction in rats.
View Article and Find Full Text PDFObjectives: This study is designed to evaluate the role of tuberoinfundibular peptide of 39 (TIP39) in connection with glucocorticoid receptor-mediated glutamate/GABA abnormalities in chronic unpredictable mild stress (CUMS) model.
Methods: Male Sprague-Dawley rats were treated with TIP39 (1 and 10 nmol, i.c.