Publications by authors named "Gummadi Sailaja"
Expression of iron transport protein Divalent metal transporter 1 (DMT1) increases in response to maternal iron deficiency anemia in near term to term placenta.
Mullapudi Venkata Surekha Thathapudi Sujatha Shravanthi Gadhiraju Putcha Uday Kumar Mudili Siva Prasad Gummadi Sailaja
J Matern Fetal Neonatal Med
March 2022
Article Synopsis
- Iron deficiency anemia (IDA) is the most common nutritional deficiency in pregnant women and affects the expression of the iron transport protein DMT1 in the placenta.
- A study involving 200 pregnant women found that 58.8% had anemia, with higher DMT1 expression levels in the placentas of anemic mothers compared to nonanemic ones.
- The results indicate that severe maternal anemia leads to increased DMT1 expression, which helps regulate iron transport to the developing fetus.
Article Synopsis
- The study investigates how maternal anemia affects the expression of angiogenic proteins in the placenta, focusing on VEGF, PLGF, nitrotyrosine, and e-NOS.
- In total, 48 pregnant women were analyzed, categorized into normal, mild, moderate, and severe anemia groups, with 58.3% being anemic.
- Results indicated that anemic mothers showed higher levels of these proteins in their placentas, suggesting that this may be a compensatory mechanism to adapt to altered blood flow and oxygen delivery.
Background: Skeletal muscle is adversely affected in type-1 diabetes, and excessively stimulated ubiquitin-proteasome system (UPS) was found to be a leading cause of muscle wasting or atrophy. The role of endoplasmic reticulum (ER) stress in muscle atrophy of type-1 diabetes is not known. Hence, we investigated the role of UPS and ER stress in the muscle atrophy of chronic diabetes rat model.
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