Cramér-Rao Bound Optimized Subspace Reconstruction in Quantitative MRI.

Objective: We extend the traditional framework for estimating subspace bases in quantitative MRI that maximize the preserved signal energy to additionally preserve the Cramer-Rao bound (CRB) of the biophysical ´ parameters and, ultimately, improve accuracy and precision in the quantitative maps.

Methods: To this end, we introduce an approximate compressed CRB based on orthogonalized versions of the signal's derivatives with respect to the model parameters. This approximation permits singular value decomposition (SVD)-based minimization of both the CRB and signal losses during compression.

Rapid quantitative magnetization transfer imaging: Utilizing the hybrid state and the generalized Bloch model.

Purpose: To explore efficient encoding schemes for quantitative magnetization transfer (qMT) imaging with few constraints on model parameters.

Theory And Methods: We combine two recently proposed models in a Bloch-McConnell equation: the dynamics of the free spin pool are confined to the hybrid state, and the dynamics of the semi-solid spin pool are described by the generalized Bloch model. We numerically optimize the flip angles and durations of a train of radio frequency pulses to enhance the encoding of three qMT parameters while accounting for all eight parameters of the two-pool model.

Cramér-Rao Bound Optimized Subspace Reconstruction in Quantitative MRI.

We extend the traditional framework for estimating subspace bases that maximize the preserved signal energy to additionally preserve the Cramér-Rao bound (CRB) of the biophysical parameters and, ultimately, improve accuracy and precision in the quantitative maps. To this end, we introduce an compressed CRB based on orthogonalized versions of the signal's derivatives with respect to the model parameters. This approximation permits singular value decomposition (SVD)-based minimization of both the CRB and signal losses during compression.

MESNA (2-Mercaptoethanesulfonate) Attenuates Brain, Heart, and Lung Injury Induced by Carotid Ischemia-Reperfusion in Rats.

Background: Ischemia-reperfusion (I/R) causes organ dysfunction as a result of the increased formation of various reactive oxygen metabolites, infiltration of inflammatory cells, interstitial edema, cellular dysfunction, and tissue death.

Aim: The study aimed to investigate the cytoprotective effect of 2-mercaptoethanesulfonate (MESNA) against tissue damage in rats exposed to carotid ischemia-reperfusion.

Materials And Methods: Twenty-four male Wistar albino rats were divided into four groups (n = 6): sham, carotid I/R, I/R + MESNA (75 mg/kg), and I/R + MESNA (150 mg/kg) groups.

Does Ambroxol alleviate kidney ischemia-reperfusion injury in rats?

Objectives: Ischemia-reperfusion injury is a life-threatening clinical problem that can occur after transplantation or a number of clinical procedures. The purpose of the study was to investigate the effects of Ambroxol on kidney damage caused by experimentally induced ischemia-reperfusion injury in rats.

Materials And Methods: Wistar albino rats were divided into 3 groups: Control (CTR, n=6), Kidney ischemia-reperfusion (K-IR, n=6), And kidney ischemia reperfusion+Ambroxol (K-IR+AMB, n=6).

Could Ambroxol reduce cytokines in hepatic ischemia-reperfusion injury in rats?

Objectives: The aim of the study is to examine the effect of Ambroxol on TNF-α and IL-1β released after liver ischemia-reperfusion injury.

Background: Many drugs are being tried to reduce ischemia-reperfusion injury, which is life threating problem after many liver surgeries. In this study, it was investigated whether Ambroxol reduces the release of pro-inflammatory cytokines released after liver ischemia-reperfusion injury.

Cramér-Rao bound-informed training of neural networks for quantitative MRI.

Purpose: To improve the performance of neural networks for parameter estimation in quantitative MRI, in particular when the noise propagation varies throughout the space of biophysical parameters.

Theory And Methods: A theoretically well-founded loss function is proposed that normalizes the squared error of each estimate with respective Cramér-Rao bound (CRB)-a theoretical lower bound for the variance of an unbiased estimator. This avoids a dominance of hard-to-estimate parameters and areas in parameter space, which are often of little interest.

Comparison of the analgesic effects of morphine and tramadol after tumor surgery in dogs.

Background: Pain thresholds may differ between animal species. It may even vary among individuals of the same species. Therefore, assessing pain in animals is challenging.

Generalized Bloch model: A theory for pulsed magnetization transfer.

Purpose: The paper introduces a classical model to describe the dynamics of large spin-1/2 ensembles associated with nuclei bound in large molecule structures, commonly referred to as the semi-solid spin pool, and their magnetization transfer (MT) to spins of nuclei in water.

Theory And Methods: Like quantum-mechanical descriptions of spin dynamics and like the original Bloch equations, but unlike existing MT models, the proposed model is based on the algebra of angular momentum in the sense that it explicitly models the rotations induced by radiofrequency (RF) pulses. It generalizes the original Bloch model to non-exponential decays, which are, for example, observed for semi-solid spin pools.

An unusual case of traumatic dorsolateral sacral hernia with retroflexion of the urinary bladder in a cat.

Background: Perineal hernias are rarely seen in cats and can be caused by congenital or trauma. The urinary bladder is the most herniated organ and was being observed in prepubic, ventral perineal, umbilical, or caudoventral abdominal regions.

Case Description: A 1-year-old female domestic short-haired cat was presented to the Animal Hospital of the Near East University Faculty of Veterinary Medicine with complaints of urinary retention as well as the inability to defecate.

Pleuroperitoneal true diaphragmatic hernia of the liver in a cat.

A 2-year old female domestic shorthair cat was referred with intermittent vomiting. Laboratory analyses revealed only an elevated alanine aminotransferase activity. Plain thoracic radiographs showed a right-sided transdiaphragm protrusion of a liver lobe into the thoracic cavity.

External fixation of fractures in children.

We report a series of 20 children with 24 fractures that were treated using the AO tubular external fixator in a paediatric orthopaedic unit. There were no major complications related to fixator use. There were two cases of superficial pin track sepsis and one case of non-union.