Publications by authors named "Gulsah Evyapan"
The skin is constantly exposed to a variety of environmental stressors, including ultraviolet (UV) radiation. Exposure of the skin to UV radiation causes a number of detrimental biological damages such as endoplasmic reticulum (ER) stress. The ER stress response is a cytoprotective mechanism that maintains homeostasis of the ER by increasing the capacity of the ER against the accumulation of unfolded proteins in the ER.
View Article and Find Full Text PDFBackground: Around the world, non-small cell lung cancer (NSCLC) is the leading cause of cancer-related deaths among all cancers. Despite advancements in new therapeutic approaches over the past few decades, the five-year survival rate still remains disappointing. The lack of effective anti-angiogenic and anti-migration drugs is the biggest obstacle to the treatment of metastatic lung cancer.
View Article and Find Full Text PDFObjective: The current study provides training to parents and teachers about pediculosis in schools in three villages in Adana to measure their knowledge level by conducting surveys and to determine the prevalence of pediculosis in these foci.
Methods: Pre- and post-questionnaires including 30 questions about pediculosis were handed to parents and teachers. The answers were analyzed with the Pearson correlation analysis.
Aim: To evaluate the inhibitory effects of ornidazole on the proliferation and migration of metastatic melanoma cell line (B16F10) in vitro and its anti-cancer effects in vivo using a melanoma mouse model.
Methods: We investigated the effects of ornidazole on cell viability (Crystal Violet and MTT assay) and migration ability (wound-healing assay) of B16F10 melanoma cells, and its ability to trigger DNA damage (Comet assay) in vitro. We also sorted CD133+ and CD133- cells from B16F10 melanoma cell line and injected them subcutaneously into Swiss albino mice to induce tumor formation.
Article Synopsis
- About half of childhood and adolescent cases of obsessive-compulsive disorder (OCD) have symptoms that persist into adulthood, and a study suggests that immunologic stress may increase the risk of developing OCD in childhood.
- Researchers analyzed the MHC complex I and II alleles in 49 children with OCD and 277 healthy peers, using various statistical methods to interpret their findings.
- The study identified specific alleles (A2, A29, C4, DRB3.1, and DRB1*16) that are associated with a higher risk of developing OCD, and it highlights a potential link between MHC genes and OCD that reflects similar associations found in autoimmune disorders.
Genotyping of Acanthamoeba T15: the environmental strain in Turkey.
Trans R Soc Trop Med Hyg
March 2015
Background: Environmental sources are potential sources for the transmission of Acanthamoeba in humans and other mammals.
Methods: A total of 50 water samples from hot springs and swimming pools, and 50 soil samples were taken from Adana, Afyon, Kutahya, Mersin and Nigde provinces in Turkey. Samples were analysed using 18S rRNA-DNA sequencing.