Drug Interaction-Informed Approaches to Inflammatory Bowel Disease Management.

Inflammatory bowel disease (IBD) is a complex and chronic condition that requires the use of various pharmacological agents for its management. Despite advancements in IBD research, the multifaceted mechanisms involved continue to pose significant challenges for strategic prevention. Therefore, it is crucial to prioritize safe and effective treatment strategies using the currently available pharmacological agents.

Efficacy of Probiotic Strains Probio65 and Probio-093 in Management of Obesity: An In Vitro and In Vivo Analysis.

The prevalence of obesity, characterized by an excessive accumulation of adipose tissue and adipocyte hypertrophy, presents a major public health challenge. This study investigates the therapeutic potential of two probiotic strains, Probio65 and Probio-093, in the context of obesity. Utilizing 3T3-L1 cell-derived human adipocytes, we assessed Probio65's and Probio-093's capacity to mitigate triglyceride accumulation and influence adipocytokine production in vitro.

Roles of breast cancer resistance protein and organic anion transporting polypeptide 2B1 in gastrointestinal toxicity induced by SN-38 under inflammatory conditions.

Drug transporters are among the factors that determine the pharmacokinetic profiles after drug administration. In this study, we investigated the roles of drug transporters involved in transport of SN-38, which is an active metabolite of irinotecan, in the intestine under inflammatory conditions in vitro and determined their functional consequences. The expression alterations of breast cancer resistance protein (BCRP) and organic anion transporting polypeptide (OATP) 2B1 were determined at the mRNA and protein levels, and the subsequent functional alterations were evaluated via an accumulation study with the representative transporter substrates [prazosin and dibromofluorescein (DBF)] and SN-38.

Survey to identify the metal accumulation pathway in humans using hair and nail as biomarkers from fisherfolk population.

Human hair and nail samples from Cuddalore fisherfolk populations were used as biomarkers for assessing metal concentrations in humans. Hair samples from 80 participants (47 men and 33 women) and nail samples from 40 participants (21 men and 19 women) were collected, and the concentrations of Cd, Cu, Pb, and Zn were assessed using an atomic absorption spectrophotometer (AAS). Metal data from AAS were compared with the survey questionnaire's personal and dietary parameters.

The novel HLA-A*11 allele, HLA-A*11:01:109:02, identified by next generation sequencing.

The novel HLA-A*11:01:109:02 allele was characterized using next generation sequencing technology.

Identification and characterization of the novel HLA-A*23:122 allele by next-generation sequencing.

The novel HLA-A*23:122 allele was characterized using next generation sequencing technology.

Heavy metal contamination along different tidal zones of a tropical Bay of Bengal coastal environment influenced by various anthropogenic activities.

The spatiotemporal variations of five heavy metals (Cd, Cu, Cr, Pb, and Zn) in the beach sediments along the Tamil Nadu coast sourced from various anthropogenic activities were assessed using atomic absorption spectrophotometry (AAS). Various pollution monitoring indices were computed to clearly understand the metal pollution status along the Tamil Nadu coastline. The metal concentrations in sediments were typically higher in the summer season than in the monsoon season.

The novel HLA-A*11:416 allele was identified during high-resolution HLA typing.

HLA-A*11:416 has one non-synonymous nucleotide change from A*11:01:01:01 in codon 39.

Two novel HLA-A alleles detected in a potential hematopoietic stem cell donors: HLA-A*03:418 and -A*26:220.

HLA-A*03:418 and -A*26:220, two novel alleles detected by next generation sequencing.

Identification of the novel HLA-A*11:01:115 allele, detected in two unrelated bone marrow donors.

HLA-A*11:01:115 has one synonymous nucleotide compared to HLA-A*11:01:01:01 in codon -5.

The detection of four novel HLA-A alleles: HLA-A*31:01:48, -A*31:210, -A*31:211 and -A*33:03:54.

Four novel HLA-A alleles HLA-A*31:01:48, -A*31:210, -A*31:211 and -A*33:03:54 alleles detected during routine next generation sequencing.

The detection of three novel HLA-A alleles: HLA-A*02:1037, -A*02:1038 and -A*02:1039.

Three novel HLA-A alleles HLA-A*02:1037, -A*02:1038 and -A*02:1039 alleles detected during routine next generation sequencing.

The detection of three novel HLA-DQB1 alleles: HLA-DQB1*02:186, -DQB1*06:02:49 and -DQB1*06:391.

Three novel HLA-DQB1 alleles HLA-DQB1*02:186, -DQB1*06:02:49, and -DQB1*06:391 alleles detected during routine next generation sequencing.

Characterization of the novel HLA-DQB1*05:277 allele, detected in two unrelated bone marrow donors.

HLA-DQB1*05:277 has one non-synonymous nucleotide change from DQB1*05:01:01:03 at codon 224.

Elicitation of the Cultures of Selected Varieties of L. With Zinc Oxide and Copper Oxide Nanoparticles for Enhanced Phytochemicals Production.

This study was conducted to develop a protocol for shoot multiplication and callus induction of various mung bean varieties to obtain enhanced phytochemical content with the help of elicitors. For shoot multiplication, two types of explants (shoot tips and nodal tips) of three varieties of mung bean (Mung NCM-13, MgAT-7, and MgAT-4) were used. Both types of explants from and sources were cultured on the MS medium supplemented with different concentrations (0.

Implications of Decreased Expression of miR-125a with Respect to Its Variant Allele in the Pathogenesis of Recurrent Pregnancy Loss: A Study in a High Incidence Zone.

Pregnancy is controlled by several types of genes and the regulation of their expression is tightly controlled by miRNAs. The present study was carried out to explore the association between miR-125a polymorphic sequence variation and its expression and recurrent pregnancy loss (RPL) compared to full-term healthy controls. A total of 150 women that had experienced two or more RPLs and 180 healthy controls (two or more full-term pregnancies) were recruited, along with 50 product of conception (POC) samples from the corresponding RPL patients, and evaluated for miR-125a SNPs by the polymerase chain reaction-restriction fragment length polymorphism method (PCR-RFLP), which was confirmed by high resolution melting (HRM)/DNA sequencing.

Network Pharmacology and Bioinformatics Approach Reveals the Multi-Target Pharmacological Mechanism of in the Treatment of Liver Cancer.

Liver cancer (LC), a frequently occurring cancer, has become the fourth leading cause of cancer mortality. The small number of reported data and diverse spectra of pathophysiological mechanisms of liver cancer make it a challenging task and a serious economic burden in health care management. is a herbaceous annual plant used in various regions of Asia to treat a variety of ailments, including liver cancer.

Effect of dietary supplementation of Neem, leaf extracts on enhancing the growth performance, chemical composition and survival of rainbow trout, .

Rainbow trout has a great nutritional value and delicious taste. A 90-days experimental trial was conducted to investigate the effect of dietary leaf extract of neem tree as a feeding supplement on the growth performance and proximate composition of . Four experimental diets were designed as T (with 5% leaf extract), T (with 7% of leaf extract), T (with 10% leaf extract), and T (control group feed with a regular diet with 0% leaf extract).

Parasitic anomalies observed in snow trout due to anthropogenic stress in water bodies.

There is interrelationship of the environmental conditions and fish health. Decrease or increase of pollution in aquatic ecosystem have direct impact on presence or absence of parasites. Fish living under optimum environmental, well-nourished conditions are more resistant to diseases than fish weakened by malnutrition caused by parasite infestation or due to deterioration of environmental conditions because ofpollution.

Modeling of Habitat Suitability and Niche Dynamics in the Himalayan Region under Anticipated Climate Change.

An increase in atmospheric greenhouse gases necessitates the use of species distribution models (SDMs) in modeling suitable habitats and projecting the impact of climate change on the future range shifts of the species. The present study is based on the BIOMOD ensemble approach to map the currently suitable habitats and predict the impact of climate change on the niche shift of Valeriana wallichii. We also studied its niche dynamics using the ecospat package in R software.

Genome-Wide Analysis of Cytochrome P450s of Species: Evolutionary Origin, Family Expansion and Putative Functions.

Cytochrome P450s are a group of monooxygenase enzymes involved in primary, secondary and xenobiotic metabolisms. They have a wide application in the agriculture sector where they could serve as a target for herbicides or fungicides, while they could function in the pharmaceutical industry as drugs or drugs structures or for bioconversions. species are among the most commonly encountered fungal genera, with most of them living as saprophytes in different habitats, while others are parasites of plants and animals.

Study of Ultrastructural Abnormalities in the Renal Cells of Induced by Toxicants.

Transmission Electron Microscopic (TEM) assessments were performed on the renal cells of common carp to observe the deleterious effects of two organophosphate insecticides, Phorate and Dimethoate. Pesticides such as Phorate and Dimethoate often pollute aquatic systems where they may negatively impact fish, but so far, the ultrastructural toxicity of these pesticides remains poorly understood. Here, we use Transmission Electron Microscopy (TEM) to determine how acute exposure to sublethal concentrations of these two pesticides may affect the renal cells of common carp .

Assessment of renal and hepatic dysfunction by co-exposure to toxic metals (Cd, Pb) and fluoride in people living nearby an industrial zone.

Togo's phosphate processing plant at Kpeme discharges waste, containing Cd, Pb, and fluoride, into the sea and on the soil. Heavy metals toxicity on kidneys and the liver has been studied. However, fluoride toxicity on these organs remains to be investigated.

Lactobacillus Sps in Reducing the Risk of Diabetes in High-Fat Diet-Induced Diabetic Mice by Modulating the Gut Microbiome and Inhibiting Key Digestive Enzymes Associated with Diabetes.

Obesity caused by a high-fat diet (HFD) affects gut microbiota linked to the risk of type-2 diabetes (T2D). This study evaluates live cells and ethanolic extract (SEL) of Probio65 and Probio-093 as natural anti-diabetic compounds. In-vitro anti-diabetic effects were determined based on the inhibition of α-glucosidase and α-amylase enzymes.