Publications by authors named "Gulnara Tuyakova"
Article Synopsis
- The study investigates how genetic variations in certain genes affect the metabolism and effects of the blood thinner dabigatran in patients with atrial fibrillation.
- Using TaqMan technology, the research analyzed genotypes from 150 patients and found significant differences in dabigatran concentrations based on specific gene polymorphisms.
- The findings suggest that polymorphisms rs8192935 and rs2244613 influence dabigatran's pharmacodynamics and pharmacokinetics, particularly in the Kazakh population.
Nowadays, direct oral anticoagulants (DOACs) are the first-line anticoagulant strategy in patients with non-valvular atrial fibrillation (NVAF). We aimed to identify the influence of polymorphisms of the genes encoding P-glycoprotein () and carboxylesterase 1 () on the variability of plasma concentrations of DOACs in Kazakhstani patients with NVAF. We analyzed polymorphisms rs4148738, rs1045642, rs2032582 and rs1128503 in and rs8192935, rs2244613 and rs71647871 genes and measured the plasma concentrations of dabigatran/apixaban and biochemical parameters in 150 Kazakhstani NVAF patients.
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