Publications by authors named "Gulminyam Baratzhanova"
The mode of action of different organochlorine pesticides families in mammalians.
Environ Toxicol Pharmacol
September 2024
Article Synopsis
- Organochlorine pesticides (OCPs) differ in chemical structure and toxicity mechanisms but share common traits like persistence and bioaccumulation, contributing to health problems.
- Despite extensive knowledge on OCP toxicity, the specific molecular mechanisms impacting mammals remain partially unknown, prompting this review to explore their modes of action.
- The review focuses on three widely used OCPs—Dichlorodiphenyltrichloroethane, Hexachlorocyclohexane, and Chlordecone—examining their biological responses and interactions in human and animal bodies.
The association of genetic polymorphisms with the individual sensitivity of humans to the action of pesticide pollution is being actively studied in the world. The aim of this study was a molecular epidemiological analysis of candidate polymorphisms of genes involved in pesticide metabolism, detoxification, and antioxidant protection. Some of the selected polymorphisms also relate to susceptibility to cancer and cardiovascular, respiratory, and immune system diseases in individuals exposed to pesticides for a long time.
View Article and Find Full Text PDFThe long-term storage of unutilized pesticides raised new problems of long-term environmental contamination. The study presents the results of surveying 151 individuals in 7 villages living close to pesticide-contaminated localities. All individuals have been surveyed concerning their consumption habits and lifestyle characteristics.
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