[Osmolality of contrast media--a risk factor in radiological endovascular procedures in children].

The study was conducted in 90 children aged from 5 months to 14 years during radiologically-guided endovascular (RIV) interventions with bolus injection of radiocontrast agents (RCA) in a dose of 2-3 ml/kg for 2-3 sec. High-osmolality RCA were used in 80 children, an nonionic low-osmolality RCA omnipaque-300 in 10 children. Injection of RCA bolus was attended by marked acute disorders of blood colloidoosmotic equilibrium (COE) which depended on the initial status of the latter and were greater when high osmolality RCA were used.

[The effect of hyperbaric oxygenation on the osmotic status of children with surgical pathology of the abdominal organs].

The effect of hyperbaric oxygenation (HBO) on blood osmolality has been studied in children with abdominal pathology. It has been shown that HBO has a considerable effect on blood osmolality evident both during and after the HBO session. To prevent possible HBO-induced disturbances of blood osmolality special pretreatment with ten infusion solutions has been suggested.

[Changes in the homeostatic indices in children with the prolonged crush syndrome receiving complex intensive therapy].

Crush syndrome was assessed clinically in 22 children, 16 of whom had renal failure. For objective evaluation, different techniques of extracorporeal detoxication were performed under dynamic control over the level of some homeostasis parameters. It has been established that the most marked changes were associated with the signs of colloid-osmotic condition and the following development of hyperosmolar syndrome.

[The diagnostic and prognostic value of the indices of the colloid-osmotic state of the blood in children with the crush syndrome].

Eighteen infants with compression syndrome (CS) were managed with simultaneous evaluation of changes in the blood colloid osmotic status. The examination findings showed that plasma osmolality is an integral index of endogenous intoxication which objectively reflects the gravity of the general condition of patients and requires adequate correction. The osmolality gap was measured by the difference between the measured and calculated osmolalities; its stable two- or threefold increase was found to be the most unfavourable factor in the disease course and prognosis.

[Preanesthetic preparation and induction anesthesia in acute cholecystitis in middle-aged and elderly patients].

Under examination there were 59 elderly and senile patients with acute cholecystitis subjected to emergency operations. It was found that among 3 kinds of initial narcosis smooth course was notable in the phentanyl-sombrevin initial narcosis. The administration of thalamonal-sombrevin initial narcosis results in a certain inhibition of blood circulation, and gives adequate anesthesia during endotracheal intubation.

[Selection of the method of postoperative analgesia in emergency proctology].

Different kinds of postoperative analgesia were used in 106 patients after urgent proctological operations. A comparative analysis of the objective and subjective data obtained have shown that epidural anesthesia is the most effective method of postoperative analgesia in urgent proctology.

[Hemodynamic function of patients with diffuse suppurative peritonitis].

A complex examination of central hemodynamics and contracting function of the heart was performed in 85 patients in the preoperative period. It was established that the toxic phase of peritonitis is characterized by the disturbed central hemodynamics and worse contracting function of the myocardium which are found to aggravate the process in the terminal phase and to require intensive prophylactic and curative measures. The authors consider that the shock index and coefficient of the functional state of central hemodynamics can be used in urgent cases for the assessment of the functional state of blood circulation.

[Effect of growth conditions on the activity of the enzymes of cyclic 3':5'-AMP synthesis and decay in phototrophic bacteria].

Activity, ratio and summary content of cyclic AMP enzymes, adenylate cyclase and phosphodiesterase varied depending on growth conditions of phototrophic bacteria (Rhodospirillum rubrum and Rhodopseudomonas palustris). It suggests, that membrane-bound and soluble enzymes carry different functions. The increase of adenylate cyclase under chaning growth conditions was usually accompanied by the increase of phosphodiesterase.

[Subcellular distribution and several properties of the cAMP enzyme system of phototrophic bacteria].

In the cells of the phototrophic bacteria Rhodospirillum rubrum and Rhodopseudomonas palustris the two enzymes of the cAMP system enzymes - adenylate cyclase and cAMP phosphodiesterase (PDE) exist in a soluble and membrane-bound forms. After mild disruption of the cells (sonication up to 3 min) the activity of both enzymes is found in the chromatophores. In the cells of the two types of bacteria grown under anaerobic conditions soluble adenylate cyclase is predominant.

[cAMP phosphodiesterase from phototrophic bacteria Rhodospirillum rubrum].

cAMP phosphodiesterase activity is discovered in supernatant of R. rubrum cell homogenate after centrifugation at 1000 g. The enzyme is highly active (5.