[The role of the main risk factors and endocrine cells of the antrum of the stomach producing motilin in the occurrence of cholelithiasis].

Aim: To establish the role of the main risk factors and endocrine cells of the antrum of the stomach producing motilin (M-cells) in the occurrence of cholelithiasis.

Materials And Methods: The first group included 122 patients with cholelithiasis. The second group consisted of 30 healthy individuals who underwent medical examination.

[The role of day hospital in optimization of medical care for patients of a therapeutic department of an outpatient clinic].

Day hospital (DH) provides consultations and treatment for all referred patients according to standards of medical care quality. DH has facilities for therapeutic and gastroenterological patients. Treatment in DH is performed according to current standards which cover basic treatment of the diseases (documented medicines, duration of treatment).

[Adaptation mechanisms of the gastric mucosa and factors that determine outcome of the therapy of acid-depended diseases associated with Helicobacter pylori on pre-hospital stage].

An efficiency of ambulant eradication therapy from patients with acid-dependent diseases was studied. The investigation was carried out in two stages. At the first stage the comparative efficiency of 4 schemes of the eradication therapy was found out of 180 patients.

[Optimization of approach to regular check-up of gastroenterological patients with acid-dependent diseases].

Aim: To optimize principles of gastroenterological care management in outpatient clinics and monitoring of medical service quality for patients with acid-dependent gastroenterological disease (ADGED) in the group of poor health patients for making decisions to optimize diagnosis, treatment and prophylaxis in outpatient setting.

Material And Methods: Regulated standards were used in examination of 448 ADGED patients. Optimisation of outpatient medical care for poor health patients was conducted basing on the 3-level model of the consulting-diagnostic process.

[Mechanism of action of Nizhne-Ivkinskaya 2K sulfate-calcium mineral water in combined treatment of acid-dependent gastrointestinal diseases].

Aim: To study efficacy of drinking mineral water (MW) nizhne-ivkinskaya 2K in combined sanatorium treatment of gastrointestinal acid-dependent diseases (ADD) and the role of endogenic modulators of M-cholinoreactivity in pathogenesis of ADD.

Material And Methods: General condition of the patients, gastric pH and peristalsis (computer system Gastrolog-M), gastric and gall bladder motility (Aloka SSD 1100), hepatic function (by bilirubin and AST and ALT activity), lipid spectrum (including LDLP and HDLP) and M-cholinomodulating activity of the blood serum (by biomethod) were examined in 134 subjects: 20 healthy subjects and 114 patients with ADD.

Results: In ADD, gastric juice acidity is high, gastric and gall bladder motility is low, total cholesterol and LDLP cholesterol are elevated, M-cholinoblocking activity of the blood serum is reduced 10-fold.

[Efficacy of sulfate calcium mineral water in disorders of motor evacuatory function of the stomach and gallbladder].

Patients with disorders of motor-evacuatory gastric function and those of the gallbladder received sanatorium spa treatment with Nizhneivkinskaya 2K mineral water. It was found that both course and single intake of the above mineral water induce clinical remission of the disease, normalization of the echoscopic picture of the stomach and gallbladder, their motor function, tesiocrystalloscopic characteristics of the saliva. Therefore, spa treatment with mineral water Nizhneivkinskaya is effective in rehabilitation of patients with gastric and gallbladder motor-evacuatory dysfunction.

[Current methods of ulcer therapy and their efficacy and cost].

The purpose of this study is to assess the efficiency of the anti-ulcer therapy taking into account the economic aspects of treatment. We have examined 708 HP-positive(+) patients with stomach ulcers (SU) and duodenal ulcers (DU). Various schemes of anti-helicobacter and anti-secretory therapy were administered to them.

[Stages in the improvement of drug therapy at a polyclinic].

Within 1968-1997 the authors studied the steps of introduction of the achievements of the medical science, technology and pharmacology to therapy of exacerbations and complications of peptic ulcer (PU). The scientific and practical value of endoscopic, histological, biochemical and bacteriological examinations in the improvement of the methods of pharmacotherapy of exacerbations and complications of PU was shown. Three phases of the PU development were indicated by the clinical signs and results of esophagogastroduodenoscopy, target biopsy and histological examinations.