Publications by authors named "Guli Humaer Yiming"
Article Synopsis
- Primary angle-closure glaucoma (PACG) is a major cause of irreversible blindness globally, primarily caused by pupil block and secondary iris synechia.
- The study aimed to identify protein differences in the aqueous humour from patients with acute primary angle closure (APAC) compared to those with cataract only, using advanced proteomic techniques.
- Researchers identified over 400 proteins in both groups, finding 91 differentially expressed proteins, including downregulated levels of matrilin2 and transforming growth factor-β2 in the APAC group, which are linked to inflammation and tissue formation processes relevant to angle closure.
Primary open-angle glaucoma (POAG) is characterized by irreversible neurodegeneration accompanied by visual field defects and high intraocular pressure. Currently, an effective treatment is not available to prevent the progression of POAG, other than treatments to decrease the high intraocular pressure. We performed proteomic analysis of aqueous humour (AH) samples from patients with POAG combined with cataract and patients with cataract to obtain a better understanding of the pathogenesis of POAG and explore potential treatment targets for this condition.
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