Publications by authors named "Gulhan Vardar Unlu"

Article Synopsis
  • * The researchers created three types of nanoparticles and tested their cytotoxicity on mouse fibroblasts and their effectiveness against different Leishmania isolates, finding that the OA-CurAgNP complex exhibited significant antileishmanial activity at varying concentrations.
  • * With current leishmaniasis treatments being highly toxic, the study suggests that the promising properties of metallic nanoparticles, especially the OA-CurAgNP complex, could lead to safer and more effective treatment options, warranting further investigation alongside traditional drugs.
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Aim: In this study, it was aimed to examine the antibacterial activity of the essential oil components (EOCs), carvacrol (CAR), cinnamaldehyde (CIN), thymol (TH), alpha pinene (α-PN), eucalyptol (EU), limonene (LIM), and the antibiotics, linezolid (LZD), vancomycin (VAN), gentamicin (GEN), ciprofloxacin (CIP), clindamycin (CLN), and penicillin (PEN) against 50 multidrug resistant Corynebacterium striatum strains, and the synergistic interactions of CAR and CIN with the antibiotics against 10 randomly selected Coryne. striatum strains to explore synergistic interactions to determine if their combined use could enhance antibiotic activity and potentially reduce resistance.

Methods And Results: The activity of the EOCs and the antibiotics against Coryne.

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Article Synopsis
  • - Trichomoniasis is a parasitic sexually transmitted infection caused by Trichomonas vaginalis, and its diagnosis can be done using various methods, with direct microscopy being the quickest but least sensitive, while culture methods are more accurate but slower and resource-dependent.
  • - The study aimed to compare the effectiveness of conventional microscopic and culture methods against the polymerase chain reaction (PCR) method for diagnosing T. vaginalis, as well as investigate gene polymorphisms thought to relate to metronidazole resistance in samples from 200 patients.
  • - Researchers collected vaginal swab samples from patients and tested them with multiple methods, finding that only 4% of the samples were positive for T. vaginalis with both culture/staining and
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Inappropriate and uncontrolled use of antibiotics in humans and animals leads to the emergence of multi-resistant bacteria. Before the discovery of antibiotics, plant extracts and essential oils were used for therapeutic purposes. Today, due to increasing antibiotic resistance, many studies are frequently carried out on the antimicrobial activities of natural active substances that can be a source for new drug candidates.

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The essential oil from the bark of Cinnamomum zeylanicum Blume was analyzed by GC-MS and bioassays were carried out. Nine constituents representing 99.24% of the oil were identified by GC-MS.

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In this study, the in vitro activity of carvacrol on 100 clinical isolates of Candida albicans was evaluated by determining the minimum inhibitory concentrations (MICs). Susceptibility of clinical isolates of C. albicans to carvacrol was determined by broth microdilution method.

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The composition of the essential oil from aerial parts of Thymbra spicata L. from Turkey was analysed by GC-MS and its in vitro antimicrobial activity was examined. GC-MS analysis of the essential oil resulted in the identification of twenty-three constituents, representing 97.

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Honeybees collect propolis from practically any abundant plant source in the neighborhood of the hive, be it populus, eucalyptus, pine, sugarcane, cashew nut or orange trees. We have described that the origin plants of Turkish propolis are Populus sp., Eucalyptus sp.

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The essential oil, obtained by Clevenger distillation, and water-soluble and water-insoluble parts of the methanol extracts of Achillea sintenisii Hub. Mor. were individually assayed for their antimicrobial activities against 12 bacteria and two yeasts, Candida albicans and C.

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The essential oil, obtained by using a Clevenger distillation apparatus, and water-soluble (polar) and water-insoluble (nonpolar) subfractions of the methanol extract of Thymus pectinatus Fisch. et Mey. var.

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