Spiro thiochromene-oxindoles as novel anti-inflammatory agents: design, sustainable synthesis, and evaluations.

A one-pot, acid-, base-, and metal-free, multicomponent strategy has been developed to synthesize spiro thiochromene-oxindole derivatives as potential anti-inflammatory agents. The synthesized compounds were screened for their anti-inflammatory activity by inhibiting heat-induced Bovine Serum Albumin (BSA) denaturation assay, revealing moderate to good efficacy. Compounds 4e, 4k, and 4h exhibited the highest activity, inhibiting BSA denaturation by 90.

Production, purification and formulation of nanoradiopharmaceutical with At: An emerging candidate for targeted alpha therapy.

Introduction: Astatine-211 has attained significant interest in the recent times as a promising radioisotope for targeted alpha therapy (TAT) of cancer. In this study, we report the production of At via Bi (α, 2n) At reaction in a cyclotron and development of a facile radiochemical separation procedure to isolate At for formulation of nanoradiopharmaceuticals.

Methods: Natural bismuth oxide target in pelletized form wrapped in Al foil was irradiated with 30 MeV α-beam in an AVF cyclotron.

Educational intervention on perceived stress among adults with type 2 diabetes and metabolic syndrome: a non-randomized clinical trial.

Objective: To evaluate the effectiveness of Virtual Teaching (VT) Programme regarding palliative care on knowledge, self-efficacy and attitude among Nursing Personnel working in selected hospitals of North India.

Methods: A quasi-experimental study with non-equivalent control group pre-test-post-test design was conducted on 121 Nursing Personnel, selected by convenient sampling technique. Knowledge, self-efficacy and attitude were assessed using structured knowledge questionnaire, Palliative Care Self-efficacy Scale, and Frommelt Attitudes toward care of dying scale respectively.

Smart proteins as a new paradigm for meeting dietary protein sufficiency of India: a critical review on the safety and sustainability of different protein sources.

India, a global leader in agriculture, faces sustainability challenges in feeding its population. Although primarily a vegetarian population, the consumption of animal derived proteins has tremendously increased in recent years. Excessive dependency on animal proteins is not environmentally sustainable, necessitating the identification of alternative smart proteins.

Implementation of temporal moments to elucidate the reactive transport of metformin and erythromycin in the saturated porous media.

This study investigates the fate and transport dynamics of metformin (MTN) and erythromycin (ETM), both classified as pharmaceutical and personal care products (PPCPs), in a saturated sandy soil column using temporal moment analysis (TMA). The key flow and transport parameters, including Darcy velocity, longitudinal dispersivity, adsorption, and degradation coefficients, were analyzed. The results reveal that MTN, a highly mobile contaminant, is eliminated from the column in approximately 40 days, while ETM shows significant adsorption due to its hydrophobic and adsorptive nature.

Monoclonal Antibodies: Current Advancements and Future Potential for Atopic Dermatitis Therapy.

Background: Atopic Dermatitis (AD) is an inflammatory skin condition with a severe itch. The topical therapy using corticosteroids is not sufficient for the effective therapy of moderate to severe cases of AD. The investigation and development of immunological targetspecific human monoclonal antibodies have changed the paradigm for the therapy of moderate to severe cases of AD.

Sexual dimorphism and topological variability in fingerprint ridge density in a north-west Indian population.

The science of fingerprints is very crucial in criminal investigation as it helps identify perpetrators or victims of a crime. Fingerprint ridge density (FPRD), which refers to the number of ridges within a specific area on the epidermal skin layer of the distal phalanges in humans, has been found to differ between males and females. This study attempts to estimate the sex from FPRD and evaluates the diversity in FPRD across several topological areas.

Thiourea as Bifunctional Hydrogen Bond Donor and Brønsted Base Catalyst for Green One-Pot Synthesis of 2-Aryl/Heteroaryl/Styryl Benzothiazoles in the Aqueous Medium under Ultrasound Irradiation.

A green organocatalysis cascade strategy using thiourea in catalytic amounts as both a hydrogen bond donor and a Brønsted base bifunctional catalyst was utilized to synthesize a series of 2-aryl/heteroaryl/styryl benzothiazole derivatives. This strategy involved an ultrasound-irradiated one-pot two-component reaction between substituted aldehydes and 2-amino thiophenols in an aqueous medium at 60 °C, using air as an oxidant. At the gram-scale, this protocol yielded 87% of the desired product, making it suitable for production at a larger scale.

Brachytherapy at the nanoscale with protein functionalized and intrinsically radiolabeled [Yb]YbO nanoseeds.

Purpose: Classical brachytherapy of solid malignant tumors is an invasive procedure which often results in an uneven dose distribution, while requiring surgical removal of sealed radioactive seed sources after a certain period of time. To circumvent these issues, we report the synthesis of intrinsically radiolabeled and gum Arabic glycoprotein functionalized [Yb]YbO nanoseeds as a novel nanoscale brachytherapy agent, which could directly be administered via intratumoral injection for tumor therapy.

Methods: Yb (T = 32 days) was produced by neutron irradiation of enriched (15.

Development, detection and decipherment of obfuscated fingerprints in humans: Implications for forensic casework.

Fingerprints have been widely used and accepted as an effective method of human identification. This biometric tool aids in criminal investigations for personal identity for over a century. Whilst the Automatic Fingerprint Identification System (AFIS) has bolstered security efforts, it has also opened doors to potential scams, affecting both civilian and law enforcement operations.

Comment on "Magnetic tubular nickel@silica-graphene nanocomposites with high preconcentration capacity for organothiophosphate pesticide removal in environmental water: Fabrication, magnetic solid-phase extraction, and trace detection" [J. Hazard. Mater. 457 (2023) 131788].

The field of adsorption is seen with mistrustfulness by Scientific Society. One of these reasons is that many users of adsorption do not have knowledge of several concepts of physical chemistry, and they spread misconceptions throughout the literature. One point that is usually found to be wrong in papers published even in prestigious Journals involving adsorption is the thermodynamics of adsorption, the use of linearization for modeling the equilibrium and kinetics of adsorption, and other misconceptions related to adsorption.

Clinical metabolomics by NMR revealed serum metabolic signatures for differentiating sarcoidosis from tuberculosis.

Background: Pulmonary sarcoidosis (SAR) and tuberculosis (TB) are two granulomatous lung-diseases and often pose a diagnostic challenge to a treating physicians.

Objective: The present study aims to explore the diagnostic potential of NMR based serum metabolomics approach to differentiate SAR from TB.

Materials And Method: The blood samples were obtained from three study groups: SAR (N = 35), TB (N = 28) and healthy normal subjects (NC, N = 56) and their serum metabolic profiles were measured using 1D H CPMG (Carr-Purcell-Meiboom-Gill) NMR spectra recorded at 800 MHz NMR spectrometer.

ChatGPT: ethical concerns and challenges in academics and research.

Introduction: The emergence of artificial intelligence (AI) has presented several opportunities to ease human work. AI applications are available for almost every domain of life. A new technology, Chat Generative Pre-Trained Transformer (ChatGPT), was introduced by OpenAI in November 2022, and has become a topic of discussion across the world.

ChatGPT: Forensic, legal, and ethical issues.

Artificial intelligence (AI) refers to a group of technologies that enable people to perform a variety of activities, including observing, comprehending, analysing and translating data, among other things. Nowadays, practically every school of thought is interested in AI. One such innovation, a chatbot by the name of ChatGPT (Chat Generative Pre-Trained Transformer), launched by OpenAI recently, has taken the internet by storm.

Mechanistic insights into contaminant transport dynamics in the saturated porous system in the presence of low permeability region using numerical simulations and temporal moment analysis.

The influence of low permeability porous media (LPPM) on contaminant transport dynamics in saturated porous systems was investigated using numerical simulations and temporal moments of contaminant concentrations. Two-dimensional flow and contaminant transport simulations were conducted, considering various parameters such as longitudinal dispersivity (ranging from 15 to 60 m), the ratio of transverse to longitudinal dispersivity (ranging from 0.05 to 0.

Methods of forensic facial reconstruction and human identification: historical background, significance, and limitations.

Facial reconstruction is the most frequently used method for human identification in forensic examinations. It is a complex and time-consuming technique and an actively growing field with a wide array of applications. The methods of forensic facial reconstruction are helpful in those cases where other methods of identification are not applicable.

Solvated electron-induced synthesis of cyclodextrin-coated Pd nanoparticles: mechanistic, catalytic, and anticancer studies.

Herein, using generated solvated electrons in the reaction media, a highly time-efficient, one-pot green approach has been employed to synthesize palladium (Pd) nanoparticles (NPs) coated with a molecular assembly of α-cyclodextrin (α-CD). The appearance of a shoulder peak at 280 nm in the UV-Vis absorption spectra indicated the formation of Pd NPs, which was further confirmed from their cubic phase XRD pattern. The nanomorphology varied considerably as a function of the dose rate, wherein sphere-shaped NPs (average size ∼ 7.

A bibliometric and visual analysis of contaminant transport modeling in the groundwater system: current trends, hotspots, and future directions.

Contaminant transport modeling (CTM) in the groundwater represents the complex bio-geo-chemical processes in the subsurface system and plays a vital role in designing remediation strategies for contaminated sites. Hence, this study evaluated 1955 articles on CTM-based studies published from 2010 to 2022 by utilizing the Scopus® database to provide a quantitative analysis of current trends and future directions. A systematic approach comprised of a bibliometric survey and visualization of various networks was conducted with the VOSviewer and Biblioshiny software for quantitative analysis of progress of CTM research field over the past decade.

Impact of prolonged wearing of face masks - medical and forensic implications.

Since December 2019, the global outbreak of coronavirus disease had a significant impact on humanity. Because of the large number of casualties worldwide, the WHO (World Health Organization) declared the coronavirus disease caused by SARS-CoV-2 a pandemic. Since the start of the pandemic, facial masks have become essential as well as mandatory to protect ourselves from COVID-19.

How Does Literacy Affect Speech Processing? Not by Enhancing Cortical Responses to Speech, But by Promoting Connectivity of Acoustic-Phonetic and Graphomotor Cortices.

Previous research suggests that literacy, specifically learning alphabetic letter-to-phoneme mappings, modifies online speech processing and enhances brain responses, as indexed by the BOLD, to speech in auditory areas associated with phonological processing (Dehaene et al., 2010). However, alphabets are not the only orthographic systems in use in the world, and hundreds of millions of individuals speak languages that are not written using alphabets.

Tandem Protocol for the Synthesis of Pyrano[3,2-]quinolone Derivatives Using Taurine as a Green Bio-Organic Catalyst in Aqueous Medium.

A series of pyrano[3,2-]quinolone derivatives has been synthesized in the presence of taurine (2-aminoethanesulfonic acid) as a green bio-organic catalyst and water as the solvent. The target compounds were synthesized through the three-component reaction between aldehydes, malononitrile/ethylcyanoacetate, and 4-hydroxy-1-methyl-2(1)-quinolone. The advantages of this protocol are excellent yields of products, short reaction times, cost efficiency, atom economy, and a simple work-up procedure with no need for extra purification techniques.

Structure-Correlated Magnetic Resonance Transverse Relaxivity Enhancement in Superparamagnetic Ensembles with Complex Anisotropy Landscape.

The aim of the work is to explore structure-relaxivity relationship by observing transverse relaxivity enhancement in magnetic resonance imaging (MRI) of differently organized superparamagnetic complex ensembles of zinc ferrite isotropic/anisotropic nanosystems. We observe that superparamagnetic systems show a correlation of MRI-transverse relaxivity, /, with spatial arrangement of nanoparticles, as well as magnetic easy axes and thermal-energy-dependent anisotropy energy landscape. The presence of highly random/partially aligned easy axes with enhanced anisotropy constant leads to modulation in transverse relaxation.

Assessment of hyaluronic acid-modified imatinib mesylate cubosomes through CD44 targeted drug delivery in NDEA-induced hepatic carcinoma.

This study aimed at the development of hyaluronic acid-functionalised imatinib mesylate cubosomes (HA-IM-CBs) that might be useful in CD44 targeting against hepatic cancer. The HA-IM-CBs had a 130.7 ± 2.