Publications by authors named "Guler Israfilova"
Research Question: What should be the optimal route of luteal support in programmed frozen embryo transfer (FET) cycles?
Design: This was a randomized, parallel, phase IV pilot trial with three groups of women undergoing FET along with hormone replacement therapy for endometrial preparation at a tertiary private IVF centre (NCT03948022). Women with at least one autologous cryopreserved blastocyst were included. After preparing the endometrium with oestradiol, 151 women were randomly assigned to one of the following three progesterone arms before embryo transfer: oral (10 mg) dydrogesterone (DYD), total daily dose 40 mg (n = 52); 8% (90 mg) progesterone vaginal gel (VAG), total daily dose 180 mg (n = 55); or intramuscular progesterone (IMP) 50 mg/ml in oil, total daily dose 100 mg (n = 44).
Article Synopsis
- Conventional assisted reproductive technology (ART) can delay cancer treatment and increase psychological stress among patients, prompting a study to compare random start (RS-COH) and conventional start (CS-COH) protocols for fertility preservation in cancer patients.
- The study involved 111 patients, focusing on outcomes like the number of oocytes and embryos produced, with findings showing that RS-COH provided a higher median number of MII (metaphase II) oocytes (7 vs. 5) but required longer stimulation time (12 vs. 10 days).
- Ultimately, the results indicated that RS-COH is as effective in producing viable oocytes as CS-COH, thereby making it a viable option for cancer patients needing