Author Correction: Evaluation of Potential Drug-Drug Interactions in the Intensive Care Unit.

Correction to: Eur Rev Med Pharmacol Sci 2021; 25 (18): 5801-5806-DOI: 10.26355/eurrev_202109_26798-PMID: 34604971 published online on September 30, 2021. The methodology section of this research article incorrectly stated that the lexi-interact checker program is freely accessible.

Antimicrobial and Antioxidant Efficacy of the Lipophilic Extract of .

The aim of this study was to investigate the compounds in the hexane extract of (Savi.) Ten. and to determine the antibacterial, antifungal, and antioxidant activities of different extracts.

Evaluation of potential drug-drug interactions in intensive care unit.

Objective: Potential drug-drug interactions (pDDIs) and adverse drug reactions (ADRs) may be frequently observed in critically ill patients because of multiple drug use. It is important to identify pDDIs before their progression to ADRs. This study aimed to determine the prevalence and effect of pDDIs and possible ADRs in intensive care patients.

Curcumin-meropenem synergy in carbapenem resistant curcumin-meropenem synergy.

Background And Objectives: The frequency of multiple resistant bacterial infections, including carbapenems, is increasing worldwide. As the decrease in treatment options causes difficulties in treatment, interest in new antimicrobials is increasing. One of the promising natural ingredients is curcumin.

Relationship between serum soluble endothelial protein C receptor level and COVID-19 findings.

Coronavirus-related disease-2019 (COVID-19)-associated coagulopathy presents predominantly with thrombosis and leads to complications in close association with inflammatory process. Soluble endothelial protein C receptor (sEPCR), which is the soluble form of EPCR, reduces the anticoagulant and anti-inflammatory activity of activated protein C. The purpose of this study is to investigate the relationship between sEPCR and the laboratory parameters and thorax computed tomography (CT) findings in the course of COVID-19.

Antibacterial effects of curcumin: An in vitro minimum inhibitory concentration study.

Aim: To evaluate the antibacterial effect of curcumin with the minimum inhibitory concentration (MIC) method in standard bacterial strains.

Methods: The in vitro antibacterial activity of curcumin was evaluated against methicillin-sensitive Staphylococcus aureus (MSSA) (ATCC 29213), methicillin-resistant Staphylococcus aureus (MRSA) (ATCC 43300), Enterococcus faecalis (ATCC 29212), Bacillus subtilis (ATCC 6633), Pseudomonas aeruginosa (ATCC 27853), Escherichia coli (ATCC 25922) and Klebsiella pneumoniae (ATCC 700603) using the macrodilution broth susceptibility test method. After incubation in tubes, the antibacterial activity of curcumin was detected by a lack of turbidity, which indicated the inhibition of bacterial growth.

Optical response of lorentzian nanoshells in the quasistatic limit.

Recently, plexcitonic systems consisting of a plasmonic nanoshell or a core covered by an excitonic shell are engineered. Such systems hold promise for tunable nanophotonic devices for imaging, chemical sensing, and resonance energy transfer. Their plasmonic response is grasped well, while understanding of their excitonic response remains to be improved.

Tumor regulation of myeloid-derived suppressor cell proliferation and trafficking.

A stress response can induce myeloid progenitor cell (MPC) proliferation, mobilization, and extramedullary hematopoiesis (EMH) within lymphoid and parenchymal organs. Our studies using in vivo BrdU labeling, Ki-67 IHC staining, and carboxyfluorescein succinimidyl ester (CFSE) adoptive cell transfer revealed that spleens, rather than bone marrow (BM) and peripheral blood (PB), from 4T1 mammary tumor-bearing (TB) mice were the primary site of MPC proliferation. The resultant increase in MPCs was associated with tumor hematopoietic growth factor (GF) transcription, decreased apoptosis, as well as, prolonged survival of splenic MPCs.

Cryopreservation of adenovirus-transfected dendritic cells (DCs) for clinical use.

In this study, we examined the effects of cryoprotectant, freezing and thawing, and adenovirus (Adv) transduction on the viability, transgene expression, phenotype, and function of human dendritic cells (DCs). DCs were differentiated from cultured peripheral blood (PB) monocytes following Elutra isolation using granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin-4 (IL-4) for 6 days and then transduced using an Adv vector with an IL-12 transgene. Fresh, cryopreserved, and thawed transduced immature DCs were examined for their: 1) cellular concentration and viability; 2) antigenicity using an allogeneic mixed lymphocyte reaction (MLR); 3) phenotype (HLA-DR and CD11c) and activation (CD83); and 4) transgene expression based on IL-12 secretion.

Mammary tumor heterogeneity in the expansion of myeloid-derived suppressor cells.

The tumor microenvironment is heterogeneous for the expansion and infiltration by myeloid derived suppressor cells (MDSCs) which has been hypothesized to be dependent on tumor burden. We report a relationships between tumor size, MDSCs and T-cells; using four murine mammary tumors to assess tumor growth, infiltration and gene expression. Our analysis of cellular infiltration into tumors and gene expression used collagenase dissociated tumors and density gradient isolation of non-parenchymal cells (NPCs).

Closing the manufacturing process of dendritic cell vaccines transduced with adenovirus vectors.

Anticancer immunotherapy using dendritic cell (DC) based vaccines provides an adjuvant therapeutic strategy that is not cross reactive with conventional therapeutics. However, manufacturing of DC vaccines requires stringent adherence to Good Manufacturing Practice (GMP) methods and rigorous standardization. Optimally this includes a closed system for monocyte isolation, in combination with closed culture and washing systems and an effective vector transduction strategy.

Controlled formation of the two-dimensional TTBC J-aggregates in an aqueous solution.

Strong experimental and theoretical evidence was provided on the controlled formation of the two-dimensional J-aggregates that were assembled in the herringbone morphology. The exciton-band structure formation of 1,1',3,3'-tetraethyl-5,5',6,6'-tetrachlorobenzimidazolocarbocyanine (TTBC) J-aggregates was investigated in ionic (NaOH) aqueous solution at room temperature. The control was achieved by changing the [TTBC] at a given [NaOH], or vice versa, and was monitored through the changes in the absorption, fluorescence excitation, and emission spectra.

Significance of the excitonic intensity borrowing in the J-/H-aggregates of bacteriochlorophylls/chlorophylls.

A quantitative analysis of the excitonic intensity borrowing for the J-/H-aggregates of the bacteriochlorophylls/chlorophylls (BChls/Chls) in specific, and of porphyrins in general, is presented. The analysis is based on the argument that the mixing between the two energetically well-separated bands, such as the Q and B bands of BChls/Chls, should be considered important if the aggregated system possesses an excitonic superstate. A remarkably simple explanation of the significance of the excitonic intensity borrowing is given: superhyperchromism is manifested by the mediation of interband coupling between the superstates in the two well-separated bands of such aggregates.

The quantitative relationship between structure and polarized spectroscopy in the FMO complex of Prosthecochloris aestuarii: refining experiments and simulations.

New absorption, linear dichroism (LD) and circular dichroism (CD) measurements at low temperatures on the Fenna-Matthews-Olson complex from Prosthecochloris aestuarii are presented. Furthermore, the anisotropy of fluorescence excitation spectra is measured and used to determine absolute LD spectra, i.e.

Synthesis of new 2,5-disubstituted-1,3,4-thiadiazoles and preliminary evaluation of anticonvulsant and antimicrobial activities.

Two new series of 2,5-disubstituted-1,3,4-thiadiazoles were synthesized for their possible anticonvulsant, antibacterial and antifungal activities. The degree of protection afforded by these compounds at a dose of 100mg/kg i.p.

Chlorophyll transition dipole moment orientations and pathways for flow of excitation energy among the chlorophylls of the major plant antenna, LHCII.

We have attempted in this work an assignment of the Qy dipole moment orientations for all the chlorophylls in the major plant antenna, light-harvesting complex II (LHCII). Information that has recently become available through a structural model of the LHCII, site-directed mutagenesis, and spectroscopy of both LHCII and CP29 has been evaluated to model the electronic excited state structure in the presence of chlorophyll-chlorophyll and chlorophyll-protein interactions. An assignment has been obtained which satisfactorily reproduces the polarized linear absorption characteristics.

Electronic Excited States of the CP29 Antenna Complex of Green Plants: A Model Based on Exciton Calculations.

We have suggested a model for the electronic excited states of the minorplant antenna, CP29, by incorporating a considerable part of the currentinformation offered by structure determination, site-directed mutagenesis,and spectroscopy in the modeling.We have assumed that the electronic excited states of the complex havebeen decided by the chlorophyll-chlorophyll (Chl) and Chl-proteininteractions and have modeled the Coulombic interaction between a pairof Chls in the point-dipole approximation and the Chl-protein interactionsare treated as empirical fit parameters.We have suggested the Q(y) dipole moment orientations and the siteenergies for all the chlorophylls in the complex through a simultaneoussimulation of the absorption and linear dichroism spectra.

The flow of excitation energy in LHCII monomers: implications for the structural model of the major plant antenna.

Spectral and kinetic information on energy transfer within the light-harvesting complex II (LHCII) monomer was obtained from this subpicosecond transient absorption study, by using selective excitation (663, 669, 672, 678, and 682 nm) of various Chl a absorption bands and detecting the induced changes over the entire Qy region (650-700 nm). It is shown that transfer from the pigment(s) absorbing around 663 nm to the low energy ones occurs in 5 +/- 1 ps, whereas the 670-nm excitation is delivered to the same "destination" in two phases (0.30 +/- 0.

Theory of exciton annihilation in complexes of a finite number of molecular sites.

A theory of the kinematics of singlet exciton annihilation in complexes of a finite number of molecular sites is developed. The theory is based on a specific scheme suggested earlier by Gülen, Wittmershaus, and Knox [Biophys J. 49:469-477 (1986)].

Theory of picosecond-laser-induced fluorescence from highly excited complexes with small numbers of chromophores.

The problem of singlet excitation kinetics and dynamics, especially at high excitation intensities, among a small number of chromophores of a given system has been addressed. A specific scheme for the kinetics is suggested and applied to CPII, a small chlorophyll (Chl)a/b antenna complex the fluorescence lifetime of which has been reported to be independent of excitation intensity over a wide intensity range of picosecond pulses. We have modeled the kinetics from the point of view that Chla molecules in CPII are Förster coupled so that a second excitation received by the group of Chla's either creates a state with two localized excitons or raises the first one to a doubly excited state.

Optical effects of sodium dodecyl sulfate treatment of the isolated light harvesting complex of higher plants.

The light-harvesting complex (LHC) of higher plants isolated using Triton X-100 has been studied during its transformation into a monomeric form known as CPII. The change was accomplished by gradually increasing the concentration of the detergent, sodium dodecyl sulfate (SDS). Changes in the red spectral region of the absorption, circular dichroism (CD), and linear dichroism spectra occurring during this treatment have been observed at room temperature.