Is the loop electrosurgical excision procedure necessary for minor cervical cytological abnormalities?

Background: To investigate the indications of loop electrosurgical excision procedure (LEEP) and its overtreatment rates for the see and treat and three step strategies in cases of atypical squamous cells of undetermined cytology (ASC-US) and low grade intraepithelial neoplasia (LGSIL) cytology.

Materials And Methods: We retrospectively analyzed colposcopy directed biopsy (CDB) and LEEP results of 176 paients with ASC-US or LGSIL cytologies who underwent colposcopic examination.

Results: Initial cytologies were ASCUS in 120 women and LGSIL in 56.

Increasing women's choices in medical abortion: a study of misoprostol 400 microg swallowed immediately or held sublingually following 200 mg mifepristone.

Objectives: To assess the efficacy and acceptability of two misoprostol regimens (400 microg oral or sublingual) following mifepristone for medical abortion.

Methods: Women seeking abortion with gestations of 56 days or less since onset of their last menstrual period were offered medical abortion as an alternative to a surgical procedure. A total of 207 eligible and consenting women were given mifepristone (200 mg oral) and the option of taking 400 microg misoprostol either orally or sublingually two days later, with the option of home-use.

Prognosticators and the role of lymphadenectomy in uterine leiomyosarcomas.

Objective: To analyze prognostic factors, the role of lymphadenectomy and postoperative adjuvant treatments in patients with uterine leiomyosarcomas (LMS).

Study Design: Sixty-three patients with uterine LMS are retrospectively analyzed with respect to both DFS and OS.

Results: Multivariate DFS analysis revealed percentage necrosis to be the unique factor to be significant (median DFS was 3.

Depth of invasion for appendiceal metastasis of ovarian cancers: does it have any clinical significance?

Aim: Depth of appendiceal metastasis in patients with epithelial ovarian carcinoma (EOC) has not been previously analyzed for a possible relationship with clinico-pathological variables.

Methods: Sixty-nine patients with EOC treated at Hacettepe University were retrospectively analyzed. All of the patients had appendiceal metastasis.

A third evaluation of tertiary cytoreduction.

Objective: To evaluate the impact of tertiary cytoreductive surgery (TCS) on patient survival and to determine predictors of optimal TCS.

Methods: Twenty patients with recurrent epithelial ovarian carcinoma who had TCS at Hacettepe University Hospital during 1992-2004 were retrospectively reviewed.

Results: Tertiary cytoreductive attempt was successful (optimal defined as <2 cm residual) in 12 patients and suboptimal in the remaining eight patients.

What is the role of office hysteroscopy in women with failed IVF cycles?

Recurrent implantation failure (RlF) may be due to unrecognized uterine pathology. Hysterosalpingography, transvaginal ultrasonography, saline infusion sonography and hysteroscopy are the tools to assess the inner architecture of the uterus. Hysteroscopy is considered to be the gold standard; however, the validity of hysteroscopy may be limited in the diagnosis of endometritis and endometrial hyperplasia.

Metastatic lymph node number in epithelial ovarian carcinoma: does it have any clinical significance?

Objective: To analyze the clinicopathological correlations of metastatic lymph node (LN) numbers in patients with epithelial ovarian carcinoma.

Method: A total of 328 patients with epithelial ovarian carcinoma diagnosed and treated at Hacettepe University Hospital during 1982-2005 were retrospectively reviewed. Patients' age, number of resected lymph nodes, clinical disease stage, preoperative Ca-125 levels, peritoneal cytology, presence of ascites, tumor histology, tumor grade, maximal tumor diameter, cytoreductive success, overall and disease-free survivals were compared with respect to the number of metastatic lymph nodes (< 4 vs.

Predictors and outcomes of recurrent disease after a negative second look laparotomy.

Background And Objectives: To analyze the predictors and outcomes of recurrent disease in patients with epithelial ovarian carcinoma (EOC) after a negative second look laparotomy (SLL).

Methods: One hundred nine EOC patients with a negative SLL treated at Hacettepe Hospital were retrospectively analyzed.

Results: Of these patients, 70 (64.

Occult metastasis in early ovarian cancers: risk factors and associated prognosis.

Objective: The purpose of this study was to define risk factors associated with the occult metastasis in early stage epithelial ovarian carcinoma (EOC), and to compare the survivals in respect to occult metastasis.

Study Design: A retrospective review of 169 patients with clinically early stage EOC was performed.

Results: Overall, 53 patients (53/169, 31.

The role of secondary cytoreduction in the treatment of ovarian cancer: Hacettepe University experience.

Objective: This study was undertaken to evaluate the role of secondary cytoreduction in patients with recurrent epithelial ovarian cancer.

Study Design: Secondarily, cytoreduced patients were retrospectively analyzed with respect to the clinicopathologic variables.

Results: A total of 64 patients were evaluated in this report.